60186-25-6

Usage

Uses

Used in Pharmaceutical Industry:
2,6-difluoropyridine-3,4-diamine is used as a key intermediate for the synthesis of various pharmaceutical drugs. Its unique chemical structure allows for the creation of a wide range of active ingredients that can be used to treat different medical conditions.
Used in Agrochemical Industry:
2,6-difluoropyridine-3,4-diaMine is also utilized as an intermediate in the synthesis of agrochemicals, which are chemicals used in agricultural practices to protect crops from pests and diseases, thereby ensuring a stable food supply.
Used in Organic Chemistry:
2,6-difluoropyridine-3,4-diamine is employed in the development of new organic compounds, thanks to its reactivity and the potential for forming various chemical bonds.
Used in Materials Science:
2,6-difluoropyridine-3,4-diaMine has potential applications in the field of materials science, where its unique properties may be harnessed to create new materials with specific characteristics, such as improved stability or reactivity.
Used in Drug Development:
2,6-difluoropyridine-3,4-diamine is used in the research and development of new drugs and pharmaceuticals, leveraging its chemical properties to design innovative therapeutic agents.

Upstream product

• 60186-20-1 4-amino-2,6-difluoro-5-nitropyridine 
• 63489-58-7 4-amino-2,6-difluoropyridine 
• 2840-00-8 4-amino-3,5-dichloro-2,6-difluoropyridine 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 
• 405230-85-5 2,6-difluoro-4-nitraminopyridine 

Downstream Products

• 60186-30-3 4,6-difluoro-1H-imidazo[4,5-c]pyridine 
• 405231-22-3 1-[(1-acetyloxy-1-ethoxy)methyl]-4,6-difluoroimidazo[4,5-c]pyridine 
• 405231-02-9 1-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4,6-difluoro-1H-imidazo[4,5-c]pyridine 
• 405231-03-0 4-amino-6-fluoro-1-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)imidazo[4,5-c]pyridine 
• 405231-04-1 4-amino-6-fluoro-1-(2,3,5-tri-O-benzyl-α-D-arabinofuranosyl)imidazo[4,5-c]pyridine 
• 405230-99-1 4,6-difluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 

Relevant academic research and scientific papers

Novel nucleosides and related processes, pharmaceutical compositions and methods

The invention provides novel nucleosides and related processes, pharmaceutical compositions, and methods. The novel nucleosides are useful in a wide variety of antiviral, antineoplastic, and antibacterial applications. Preferred embodiments of the instant invention include novel 2 halogen-substituted, 3 halogen-substituted, and 2′,3′dihalogen-substituted analogues of 3-deazaadenosine, and novel 3 halogen-substituted analogues of 3-deazaguanosine. Compounds of the instant invention, including 4-Amino-6-fluoro-1-(β-D-ribofuranosyl)imidazo[4,5-c]pyridine and 6-Amino-7-bromo-1,5-dihydro-1-β-D-ribofuranosylimidazo[4,5-c]pyridin-4-one, have exhibited potent antiviral and anticancer activity in vitro. The compounds are also useful in the concomitant treatment of bacterial infections associated with viral infections such as AIDS.

Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents

Various 2-halogen-substituted analogues (38, 39, 43 and 44), 3-halogensubstituted analogues (51 and 52), and 2′,3′ -dihalogen- substituted analogues (57-60) of 3-deazaadenosine and 3-halogen-substituted analogues (61 and 62) of 3-deazaguanosine have been synthesized as potential anticancer and/or antiviral agents. Among these compounds, 3-deaza-3-bromoguanosine (62) showed significant cytotoxicity against L1210, P388, CCRF-CEM and B16F10 cell lines in vitro, producing IC50 values of 3, 7, 9 and 7μM, respectively. Several 3-deazaadenosine analogues (38, 51, 57 and 59) showed moderate to weak activity against hepatitis B virus.