60186-30-3

Usage

Uses

Used in Pharmaceutical Industry:
4,6-difluoro-1H-imidazo[4,5-c]pyridine serves as a key building block in the development of drugs targeting the central nervous system. Its unique structure and biological activities make it a promising candidate for creating novel therapeutic agents.
Used in Organic Synthesis:
In the realm of organic synthesis, 4,6-difluoro-1H-imidazo[4,5-c]pyridine is utilized as a versatile starting material for the creation of more complex molecules. Its presence in various synthetic pathways underscores its importance in the synthesis of a wide range of compounds with diverse applications.
Used in Research and Development:
4,6-difluoro-1H-imidazo[4,5-c]pyridine's demonstrated biological activities have positioned 4,6-difluoro-1H-imidazo[4,5-c]pyridine as an interesting target for ongoing research and development. Its potential applications in drug discovery and the synthesis of novel molecules make it a valuable subject for scientific exploration and innovation.

Upstream product

• 14036-06-7 diethoxymethyl acetate 
• 60186-25-6 3,4-diamino-2,6-difluoropyridine 
• 405231-22-3 1-[(1-acetyloxy-1-ethoxy)methyl]-4,6-difluoroimidazo[4,5-c]pyridine 
• 63489-58-7 4-amino-2,6-difluoropyridine 
• 60186-20-1 4-amino-2,6-difluoro-5-nitropyridine 
• 2840-00-8 4-amino-3,5-dichloro-2,6-difluoropyridine 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 
• 405230-85-5 2,6-difluoro-4-nitraminopyridine 

Downstream Products

• 405231-03-0 4-amino-6-fluoro-1-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)imidazo[4,5-c]pyridine 
• 405231-04-1 4-amino-6-fluoro-1-(2,3,5-tri-O-benzyl-α-D-arabinofuranosyl)imidazo[4,5-c]pyridine 
• 405231-02-9 1-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4,6-difluoro-1H-imidazo[4,5-c]pyridine 
• 405230-99-1 4,6-difluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 

Relevant academic research and scientific papers

ADENYLYL CYCLASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF

The present invention relates to novel adenine based inhibitors of adenylyl cyclase of the formula: wherein X, L, R1, R2, R5 are those defined herein. Compounds of the present invention are useful to treat cardiovascular diseases. The present invention also relates to a method of preventing heart failure by administering an effective amount of compound according to the invention following vascular injury and reperfusion therapy.

Novel nucleosides and related processes, pharmaceutical compositions and methods

The invention provides novel nucleosides and related processes, pharmaceutical compositions, and methods. The novel nucleosides are useful in a wide variety of antiviral, antineoplastic, and antibacterial applications. Preferred embodiments of the instant invention include novel 2 halogen-substituted, 3 halogen-substituted, and 2′,3′dihalogen-substituted analogues of 3-deazaadenosine, and novel 3 halogen-substituted analogues of 3-deazaguanosine. Compounds of the instant invention, including 4-Amino-6-fluoro-1-(β-D-ribofuranosyl)imidazo[4,5-c]pyridine and 6-Amino-7-bromo-1,5-dihydro-1-β-D-ribofuranosylimidazo[4,5-c]pyridin-4-one, have exhibited potent antiviral and anticancer activity in vitro. The compounds are also useful in the concomitant treatment of bacterial infections associated with viral infections such as AIDS.

Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents

Various 2-halogen-substituted analogues (38, 39, 43 and 44), 3-halogensubstituted analogues (51 and 52), and 2′,3′ -dihalogen- substituted analogues (57-60) of 3-deazaadenosine and 3-halogen-substituted analogues (61 and 62) of 3-deazaguanosine have been synthesized as potential anticancer and/or antiviral agents. Among these compounds, 3-deaza-3-bromoguanosine (62) showed significant cytotoxicity against L1210, P388, CCRF-CEM and B16F10 cell lines in vitro, producing IC50 values of 3, 7, 9 and 7μM, respectively. Several 3-deazaadenosine analogues (38, 51, 57 and 59) showed moderate to weak activity against hepatitis B virus.