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Bodybuilding organic Creatine Powder Supplement Creatine creatine monohydrate
Cas No: 57-00-1
USD $ 9.8-14.9 / Kilogram 100 Kilogram 100000 Kilogram/Year Xi'an Quanao Biotech Co., Ltd. Contact Supplier
Bodybuilding organic Creatine Monohydrate Creatine Powder Supplement Monohydrate Factory Supply Creatine monohydrate
Cas No: 57-00-1
USD $ 495.0-495.0 / Metric Ton 1 Metric Ton 500 Kilogram/Day Shaanxi Yuantai Biological Technology Co., Ltd. Contact Supplier
Creatine Anhydrous CAS NO.57-00-1
Cas No: 57-00-1
USD $ 10.0-10.0 / Kilogram 1 Kilogram 10000 Kilogram/Month HANWAYS CHEMPHARM CO.,LIMITED Contact Supplier
Creatine Manufacturer/High quality/Best price/In stock
Cas No: 57-00-1
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality Creatine Anhydrous supplier in China
Cas No: 57-00-1
No Data 1 Kilogram 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Creatine
Cas No: 57-00-1
USD $ 8.0-10.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier
57-00-1 Glycine,N-(aminoiminomethyl)-N-methyl-
Cas No: 57-00-1
USD $ 40.0-50.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Food supplement Creatine 57-00-1
Cas No: 57-00-1
No Data 20 Metric Ton 200 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
CREATINE(P)
Cas No: 57-00-1
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
Factory supply high quality Creatine,57-00-1
Cas No: 57-00-1
No Data No Data Metric Ton/Day Hubei Taiho Chemical Co.,LTD Contact Supplier

57-00-1 Usage

Uses

1. It can be used as the nutritional supplements for promoting the adaptation of skeletal muscle to strenuous exercise and fighting against the excessive fatigue for feeble individuals.
2. It can be used as the drugs for the treatment of heart disease and respiratory insufficiency.
3. It can be used for preparation of a pharmaceutical formulation containing human growth hormone.
4. It can be applied to compound health food with anti-aging and physical-power recovering effect.
5. It can be used as the reagents for biochemical research.

General description

Creatine is a kind of natural nutrients in presented in the human body and can also be synthesize through arginine, glycine, and methionine in the liver, kidney and pancreas: in the presence of the catalysis of the arginine/glycine transamidinase in the kidney, the amidino group of the arginine can be transferred to the amino group of the glycine, generating glycocyamine. Then in the liver, with the catalysis of the glycocyamine methyltransferase, the methyl group of the S-adenosylmethionine can be transferred to the glycocyamine, generating creatine; it can increase the water content of the muscle cells, help the muscle cells to store energy, increase the protein synthesis and some other fundamental functions; wherein the artificially synthetic creatine can be used as the nutritional supplements for promoting the adaptation of skeletal muscle on fierce exercise and fighting against the excessive fatigue of individual in weakness; it can also be used for making the drugs for the treatment of heart disease and respiratory insufficiency; it can be used for making the pharmaceutical formulation containing human growth hormones; it can be applied to the compound health food, with anti-aging and physical power-recovering effect.

Side Effects

1. Byproducts
Low-purity creatine not only has no apparent effect, but also is harmful to the human body. The major harmful substance is a derivatives called dicyandiamide. It will increase the burden of renal excretion. In the product of creatine of 99.99% purity, the dicyandiamide content is less than 20PPM.
2. Energy Source
The movement of the human muscles relies on the energy decomposed by adenosine triphosphate (ATP]. In high-intensity exercise, ATP will be totally depleted within a few seconds exploded, meaning it can only provide a few seconds of energy. In the aerobic exercise, it can be synthesized from the aerobic decomposition of carbohydrates and fats. But in anaerobic exercise, due to the lack of oxygen, creatine began to be involved to energy metabolism. It can combine with phosphoric acid to synthesize creatine phosphate (CP) and quickly replenish ATP. Theoretically, the more the creatine is stored, the more the synthesis of CP will be and the longer time the ATP can be supplied. In that case, the muscle can persist for a longer time at high-intensity exercise. In the recovering period, the synthesis of creatine still relies on carbohydrates for aerobic energy supplying. Therefore, the intake of carbohydrates should not be too small. Otherwise, after the decomposition of creatine, it can’t be synthesized and can’t supply the energy in the next training.
3. Danger
Because the creatine can quickly supplement energy, there may be overtraining phenomenon during the exercise.

Production method

1. For taking lime nitrogen as raw materials for preparing creatine, there are three different process routes:
Lime nitrogen has direct reaction with the aqueous solution of sodium sarcosine to generate creatine.
Lime nitrogen is reacted with the methanol solution pre-saturated with dry hydrogen chloride gas to generate O-methylisourea hydrochloride which is further subject to reaction with sarcosine to generate creatine.
Upon the condition of passing air, lime nitrogen was reacted with aqueous hydrochloric acid to generate chlorinated formamidine chloride which further reacts with sarcosine sodium to generate creatine.
2. Cyanamide is reacted with chloroacetic acid, methylamine to generate creatine monohydrate.
3. Take thiourea and dimethyl sulfate as raw materials to generate S-methylisothiourea sulfate which then have reaction with sarcosine, sodium sarcosine or potassium sarcosine to generate creatine.
4. Take urea and dimethyl sulfate as raw materials to generate O-methyl isourea sulfate which then reacts with sodium sarcosine to generate creatine monohydrate.

Figure 1 The reaction formula for production of creatine
Operation method: add 3.3 mol of urea and 6 mL 50% H2SO4 to a 500 mL four-necked flask equipped with a stirrer, a thermometer, a dropping funnel and a condenser; heat to 40 ℃, add drop wise of 3 mol dimethyl sulfate under stirring for 3 h; during the addition of raw materials, the temperature should be maintained at less than 70 ℃; after the completion of adding the material, stir for 2h about 70 ℃, and cool to obtain 561.8 g of O-methyl isourea sulfate. Add 61.7 of 36% aqueous solution of sodium sarcosinate to a 500 mL four-necked flask equipped with a stirrer, a thermometer, a dropping funnel and a condenser, use 30% HCl to adjust the pH to about 11.0, and then add drop wise at 20 ℃ of 50 g of O-methyl isourea sulfate within 2 h; during the process of adding, drop wise, use 25% NaOH solution to adjust the pH and maintain the pH at about 11.0, after the addition was complete, stirring was continued at 40 ℃ for 2 h, and then cool the mixture at 0 ~5℃ for 2h and filter out the formed colorless crystals. Use 2 × 15 mL of ice water to wash the filter cake to generate crude creatine monohydrate. Put the crude product into beaker, add water of 7 to 8 times the amount of crude product, heat to dissolve all the crude product, have liquid be subject to slow cooling at room temperature, crystallized, filter off the crystals, dry at a temperature below 50 ℃ to obtain the finished product of creatine monohydrate .

Physical and Chemical Properties

It is prismatic crystals (containing one crystal water molecule) with the melting point being 303 ℃ and the relative density of 1.33. It is soluble in boiling water and 98% acetic acid, slightly soluble in ethanol but insoluble in diethyl ether and butyrate. It can react with inorganic acid to obtain creatinine and co-heat with total soda lime to generate methylamine. It can be used to generate ammonia when being subject to azeotrope with potassium hydroxide and can react with potassium permanganate to generate methyl guanidine oxalic acid and guanidine; at room temperature, its aqueous solution can react with mercuric acetate role to generate guanidino glyoxylic acid, finally generating oxalic acid and guanidine In the reaction of the self-digestion in the muscle juice or organ extract, it can be converted to creatinine.

Pharmacological effects

1. Increase the water content of muscle cells:
During the initial stage of using creatine, you can feel obviously that the muscles can become larger and stronger. This is because creatine leads to that the body's muscle cells store a relatively large amount of water; and when all the muscle cells absorb large amounts of water and get increased volume, the muscle will certainly become more full, visible.
2. Help the muscle cells to store energy:
Human muscle fiber contains two different forms of creatine: non-bonded creatine and phosphate-containing creatine phosphate; among them, creatine phosphate accounts for about two-thirds of the total creatine content. When muscle gets contraction for exercise, the body will use a compound called ATP as the energy source. Unfortunately, the body's muscle cells can only support the ATP energy which is enough for only less than ten seconds rapid contraction. Therefore, more ATP must be produced in order to maintain continuous movement. At this time, the creatine phosphate stored in muscle will sacrifice their phosphoric acid group for biosynthesis of ATP again. Therefore, if the muscles contain more creatine, the muscle will have greater potential for exert its strength.
In addition, the supplement of the creatine can also help the exhausted muscles cells to rejuvenate. This is because when the muscle ATP energy is depleted, the body can use glycolysis pathway to produce lactic acid. When the body undergoes fierce exercise, a large number of lactic acid can be produced to make the muscles get soreness and fatigue; at this time if the muscle can store relative large amount of creatine phosphate for providing more ATP, the body will reduce the lactic acid manufacturing and reduce fatigue of muscle cells so that we can exercise more durable and more explosive.
3. Increase the biosynthesis of proteins:
The uptake of creatine makes the body be able to use more protein for muscle growth. Moreover, the two proteins in the muscle structure; actin and myosin, is exactly the main component to lead to muscle fiber contraction and movement. Therefore, if we can supplement sufficient amount of creatine for our bodies, our body can reduce the energy consumed for protein synthesis so that we can have more energy to synthesize large amount of actin and myosin cells, therefore, our muscle will certainly become stronger and more powerful.

Chemical Properties

White powder

Purification Methods

Likely impurities are creatinine and other guanidino compounds. It crystallises from the minimum volume of boiling H2O as the monohydrate. The hydrate is also obtained by dissolving in H2O and adding Me2CO. Drying under vacuum over P2O5 or drying at 100o gives the anhydrous base. The anhydrous base can be obtained also by dissolving the hydrate in H2O, seeding with the anhydrous base and cooling in ice. A m of 258 -268o(dec) was reported. The picrate crystallises from 17 parts of H2O with m of 218-220o(dec). [King J Chem Soc 2377 1930, Hoffmann et al. J Am Chem Soc 58 1730 1936, Mendel & Hodgkin Acta Cryst 7 443 1954, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2750 1961, Beilstein 4 III 1170, 4 IV 2425.]
InChI:InChI=1/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)

57-00-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A17477)  Creatine, anhydrous, 98%    57-00-1 100g 770.0CNY Detail
Alfa Aesar (A17477)  Creatine, anhydrous, 98%    57-00-1 25g 282.0CNY Detail

57-00-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Creatine

1.2 Other means of identification

Product number -
Other names Krebiozon

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57-00-1 SDS

57-00-1Synthetic route

calcium cyanamide
156-62-7

calcium cyanamide

sodium sarcosinate
4316-73-8

sodium sarcosinate

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
With phosphoric acid; sulfuric acid86%
phosphoric acid75%
sulfuric acid
sarcosine
107-97-1

sarcosine

Aminoiminomethanesulfinic acid
1758-73-2

Aminoiminomethanesulfinic acid

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
With sodium hydroxide at 20℃; Substitution; N-Formamidinylation;83.2%
CYANAMID
420-04-2

CYANAMID

sodium sarcosinate
4316-73-8

sodium sarcosinate

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
Stage #1: sodium sarcosinate With hydrogenchloride In water pH=9.6; Cooling;
Stage #2: CYANAMID In water at 75 - 80℃; for 3.5h;
76.2%
In 2-Methyl-1,2-propanediol75%
With carbon dioxide In water at 75℃; for 6h; pH=9 - 10;75%
With formic acid In tert-butyl methyl ether at 50℃; for 1h; pH=9.8;70%
With ammonium chloride68%
guanidineacetic acid
352-97-6

guanidineacetic acid

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
With aluminum (III) chloride; potassium carbonate at 95℃; for 3h; Temperature; Large scale;75.61%
Creatinine
60-27-5

Creatinine

Creatinine
57-00-1

Creatinine

creatinine
60-27-5

creatinine

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
With calcium hydroxide
With water
With water at 36℃; Ein Gleichgewicht zwischen Kreatin und Kreatinin stellt sich nach 11 Monaten ein;
With ammonia
sarcosine
107-97-1

sarcosine

CYANAMID
420-04-2

CYANAMID

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
With ammonia
With ethanol at 100℃;
sarcosine
107-97-1

sarcosine

guanidine hydrogen carbonate
124-46-9, 20734-13-8, 100224-74-6, 593-85-1

guanidine hydrogen carbonate

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
With creatinine; water
sarcosine
107-97-1

sarcosine

2-methylisothiourea sulphate
14527-26-5, 867-44-7

2-methylisothiourea sulphate

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
With ammonium hydroxide
With ammonium hydroxide
sarcosine
107-97-1

sarcosine

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
in Muskel-Praeparaten;
methylphosphate
812-00-0

methylphosphate

guanidineacetic acid
352-97-6

guanidineacetic acid

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
unter der Einwirkung von Leber-Praeparaten;
in Gegenwart von Rattenleberbrei unter anaeroben Bedingungen;
L-methionine
63-68-3

L-methionine

guanidineacetic acid
352-97-6

guanidineacetic acid

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
im Organismus von Ratten und Kaninchen;
unter der Einwirkung von Weizenkeim-Praeparaten;
unter der Einwirkung von Leber-Praeparaten;
unter der Einwirkung von Muskel-Praeparaten;
trimethylamine-N-oxide
1184-78-7

trimethylamine-N-oxide

choline
62-49-7

choline

Creatinine
57-00-1

Creatinine

choline
62-49-7

choline

guanidineacetic acid
352-97-6

guanidineacetic acid

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
unter der Einwirkung von Muskel-Praeparaten;
im Organismus von Ratten bei gleichzeitiger Verabreichung von Homocystin;
guanidineacetic acid
352-97-6

guanidineacetic acid

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
biochemische Methylierung;
im Organismus des Kaninchens;
Phosphocreatine
67-07-2

Phosphocreatine

Creatinine
57-00-1

Creatinine

betaine
107-43-7

betaine

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
im Organismus der Ratte;
cholin hydroxide
123-41-1

cholin hydroxide

A

creatinine
60-27-5

creatinine

B

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
Bei der Einw.von Gemischen aus Gehirn- und Leberbrei von Hunden oder Ratten in Gegenwart von Arginin oder Harnstoff;
Bei der Einw.von Gemischen aus Muskel- und Leberbrei von Hunden oder Ratten in Gegenwart von Arginin oder Harnstoff;
sarcosine
107-97-1

sarcosine

2-methyl-isourea
2440-60-0

2-methyl-isourea

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
With methanol
L-arginine
74-79-3

L-arginine

glycine
56-40-6

glycine

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
in Leber und Muskel-Praeparaten sowie im Organismus;
sarcosine
107-97-1

sarcosine

S-methylthiouronium iodide
4338-95-8

S-methylthiouronium iodide

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
With sodium hydroxide
Creatinine
60-27-5

Creatinine

ammonia
7664-41-7

ammonia

Creatinine
57-00-1

Creatinine

Creatinine
60-27-5

Creatinine

water
7732-18-5

water

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
at 36℃;
Creatinine
60-27-5

Creatinine

ammonium hydroxide

ammonium hydroxide

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
at 20℃;
Creatinine
60-27-5

Creatinine

4water

4water

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
at 20℃;
Creatinine
60-27-5

Creatinine

water
7732-18-5

water

lead hydroxide

lead hydroxide

Creatinine
57-00-1

Creatinine

flesh-extract

flesh-extract

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
With mercury(II) sulfate sowie aus Geweben und Fluessigkeiten des Koerpers;
With hydrochloride of HgCl2 sowie aus Geweben und Fluessigkeiten des Koerpers;
Liebig's flesh-extract

Liebig's flesh-extract

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
With ethanol
Liebig's urine

Liebig's urine

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
ueber das Kreatinin-ZnCl2-Doppelsalz;
Thioctic acid
1077-28-7, 62-46-4

Thioctic acid

Creatinine
57-00-1

Creatinine

creatine α-lipoate

creatine α-lipoate

Conditions
ConditionsYield
at 75℃; for 0.166667h;98%
glycine
56-40-6

glycine

Creatinine
57-00-1

Creatinine

creatine glycinate
859980-98-6

creatine glycinate

Conditions
ConditionsYield
In water at 50℃; for 1h;97%
O-acetyl-L-carnitine hydrochloride
5080-50-2

O-acetyl-L-carnitine hydrochloride

Creatinine
57-00-1

Creatinine

acetyl L-carnitine creatinate hydrochloride

acetyl L-carnitine creatinate hydrochloride

Conditions
ConditionsYield
In 2-methyl-propan-1-ol; water at 40℃;96%
L-carnitine
541-15-1

L-carnitine

Creatinine
57-00-1

Creatinine

L-carnitine creatinate phosphate

L-carnitine creatinate phosphate

Conditions
ConditionsYield
With phosphoric acid In 2-methyl-propan-1-ol; water at 40℃;95%
5-(1-oxo-1,3-dihydroisobenzofuran-5-yl)thiophene-2-carbaldehyde
1313397-92-0

5-(1-oxo-1,3-dihydroisobenzofuran-5-yl)thiophene-2-carbaldehyde

Creatinine
57-00-1

Creatinine

(E,Z)-2-imino-1-methyl-5-((5-(1-oxo-1,3-dihydroisobenzofuran-5-yl)thiophen-2-yl)methylene)imidazolidin-4-one
1313397-09-9

(E,Z)-2-imino-1-methyl-5-((5-(1-oxo-1,3-dihydroisobenzofuran-5-yl)thiophen-2-yl)methylene)imidazolidin-4-one

Conditions
ConditionsYield
With acetic acid; 3-amino propanoic acid for 15h; Reflux;95%
Creatinine
57-00-1

Creatinine

Creatinine
60-27-5

Creatinine

Conditions
ConditionsYield
With acetic acid for 2h; Reagent/catalyst; Reflux;93.4%
With water
With hydrogenchloride
Creatinine
57-00-1

Creatinine

Disodium phosphocreatine

Disodium phosphocreatine

Conditions
ConditionsYield
With triethylamine; trichlorophosphate In acetonitrile at -4 - 0℃; for 15.1h; Time;92.9%
Creatinine
57-00-1

Creatinine

7-methyl-2,3-dihydro-3-dimethylaminomethylenethiopyrano[2,3-b]pyridin-4(4H)-one
640265-22-1

7-methyl-2,3-dihydro-3-dimethylaminomethylenethiopyrano[2,3-b]pyridin-4(4H)-one

8-methyl-N-methyl-N-(5H-pyrido[3',2';5,6]thiopyrano[3,4-d]pyrimidin-2-yl)glycine

8-methyl-N-methyl-N-(5H-pyrido[3',2';5,6]thiopyrano[3,4-d]pyrimidin-2-yl)glycine

Conditions
ConditionsYield
Stage #1: Creatinine With sodium ethanolate In ethanol at 20℃; for 0.25h;
Stage #2: 7-methyl-2,3-dihydro-3-dimethylaminomethylenethiopyrano[2,3-b]pyridin-4(4H)-one In ethanol for 4h; Heating;
91%
Creatinine
57-00-1

Creatinine

C4H8ClN3O

C4H8ClN3O

Conditions
ConditionsYield
With thionyl chloride In dichloromethane at 0 - 5℃; for 1h; Inert atmosphere;90%
ethanol
64-17-5

ethanol

Creatinine
57-00-1

Creatinine

ethyl 2-(3-methylguanidino)acetate hydrochloride
15366-32-2

ethyl 2-(3-methylguanidino)acetate hydrochloride

Conditions
ConditionsYield
With phosgene; dmap at 10℃; for 0.5h; Reagent/catalyst; Sealed tube;89%
With chlorophosphonic acid at 0 - 60℃; for 0.75h;73%
at 37℃; for 20h; Product distribution / selectivity; Acidic conditions;54%
7-methyl-4-oxo-(4H)-1-benzopyran-3-carbaldehyde
40682-97-1

7-methyl-4-oxo-(4H)-1-benzopyran-3-carbaldehyde

Creatinine
57-00-1

Creatinine

[{5-[(2-hydroxy-4-methylphenyl)carbonyl]pyrimidin-2-yl}(methyl)amino]acetic acid

[{5-[(2-hydroxy-4-methylphenyl)carbonyl]pyrimidin-2-yl}(methyl)amino]acetic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol for 14h; Reflux;86%
1-(1-dimethylaminomethylene-2-oxo-2-phenylethyl)-3,5-diphenyl-1H-pyrazole
144455-11-8

1-(1-dimethylaminomethylene-2-oxo-2-phenylethyl)-3,5-diphenyl-1H-pyrazole

Creatinine
57-00-1

Creatinine

{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-acetic acid
144454-94-4

{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-acetic acid

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 12h; Heating;85%
benzyl alcohol
100-51-6

benzyl alcohol

Creatinine
57-00-1

Creatinine

creatine benzyl ester hydrochloride
404576-05-2

creatine benzyl ester hydrochloride

Conditions
ConditionsYield
With chlorophosphonic acid at 20℃; for 2h;85%
copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

hydrazine hydrate

hydrazine hydrate

Creatinine
57-00-1

Creatinine

[bis(2-(carbamimidoyl(methyl)amino)acetate)-bis(hydrazinate)copper(II)]

[bis(2-(carbamimidoyl(methyl)amino)acetate)-bis(hydrazinate)copper(II)]

Conditions
ConditionsYield
In water for 1h;84%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

Creatinine
57-00-1

Creatinine

N-(imino{[(4 methylphenyl)sulfonyl]amino}methyl)-Nmethylglycine

N-(imino{[(4 methylphenyl)sulfonyl]amino}methyl)-Nmethylglycine

Conditions
ConditionsYield
With sodium carbonate In water82.7%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

Creatinine
57-00-1

Creatinine

N-[{bis[(4-methylphenyl)sulfonyl]amino}(imino)methyl]-N-methylglycine

N-[{bis[(4-methylphenyl)sulfonyl]amino}(imino)methyl]-N-methylglycine

Conditions
ConditionsYield
With sodium carbonate In water82.2%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Creatinine
57-00-1

Creatinine

N-[[bis(phenylsulfonyl)amino](imino)methyl]-N-methylglycine

N-[[bis(phenylsulfonyl)amino](imino)methyl]-N-methylglycine

Conditions
ConditionsYield
With sodium carbonate In water81.3%
ethanol
64-17-5

ethanol

Creatinine
57-00-1

Creatinine

A

ethyl 2-(3-methylguanidino)acetate hydrochloride
15366-32-2

ethyl 2-(3-methylguanidino)acetate hydrochloride

B

ethyl acetate
141-78-6

ethyl acetate

Conditions
ConditionsYield
Stage #1: ethanol With acetyl chloride at 35 - 60℃;
Stage #2: Creatinine at 35 - 50℃; for 2 - 8h;
A 80%
B n/a
Stage #1: ethanol With acetyl chloride
Stage #2: Creatinine at 37℃; for 10 - 20h; Product distribution / selectivity;
A 37%
B n/a
cobalt(II) nitrate hexahydrate

cobalt(II) nitrate hexahydrate

copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

nickel(II) nitrate hexahydrate

nickel(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

hydrazine hydrate

hydrazine hydrate

Creatinine
57-00-1

Creatinine

0.14,0.2,0.08,

0.14,0.2,0.08,

Conditions
ConditionsYield
In water for 1h;77%
2-(Dimethylaminomethylene)-3,4-dihydro-1(2H)-naphthalenone
34773-02-9

2-(Dimethylaminomethylene)-3,4-dihydro-1(2H)-naphthalenone

Creatinine
57-00-1

Creatinine

[(5,6-dihydro-benzo[h]quinazolin-2-yl)-methyl-amino]-acetic acid

[(5,6-dihydro-benzo[h]quinazolin-2-yl)-methyl-amino]-acetic acid

Conditions
ConditionsYield
Stage #1: Creatinine With sodium ethanolate In ethanol at 20℃; for 0.25h; Metallation;
Stage #2: 2-(Dimethylaminomethylene)-3,4-dihydro-1(2H)-naphthalenone In ethanol for 10h; Cyclization; Heating;
74%
2-((dimethylamino)methylene)cyclohexanone
6135-19-9

2-((dimethylamino)methylene)cyclohexanone

Creatinine
57-00-1

Creatinine

[methyl-(5,6,7,8-tetrahydro-quinazolin-2-yl)-amino]-acetic acid

[methyl-(5,6,7,8-tetrahydro-quinazolin-2-yl)-amino]-acetic acid

Conditions
ConditionsYield
Stage #1: Creatinine With sodium ethanolate In ethanol at 20℃; for 0.25h; Metallation;
Stage #2: 2-((dimethylamino)methylene)cyclohexanone In ethanol for 10h; Cyclization; Heating;
72%
cobalt(II) nitrate hexahydrate

cobalt(II) nitrate hexahydrate

magnesium(II) nitrate hexahydrate

magnesium(II) nitrate hexahydrate

copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

nickel(II) nitrate hexahydrate

nickel(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

hydrazine hydrate

hydrazine hydrate

Creatinine
57-00-1

Creatinine

0.16,0.14,0.08,0.06,1.56

0.16,0.14,0.08,0.06,1.56

Conditions
ConditionsYield
In water for 1h;71%
6-chloro-5-7-dimethyl-4oxo-4H-chromene-3-carbaldehyde

6-chloro-5-7-dimethyl-4oxo-4H-chromene-3-carbaldehyde

Creatinine
57-00-1

Creatinine

[{5-[(3-chloro-6-hydroxy-2,4-dimethylphenyl)carbonyl]pyrimidin-2-yl}(methyl)amino]acetic acid

[{5-[(3-chloro-6-hydroxy-2,4-dimethylphenyl)carbonyl]pyrimidin-2-yl}(methyl)amino]acetic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol for 14h; Reflux;70%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Creatinine
57-00-1

Creatinine

N-{imino[(phenylsulfonyl)amino]methyl}-N-methylglycine

N-{imino[(phenylsulfonyl)amino]methyl}-N-methylglycine

Conditions
ConditionsYield
With sodium carbonate In water64.7%
3-(Dimethylaminomethylene)-4-chromanone
74396-87-5

3-(Dimethylaminomethylene)-4-chromanone

Creatinine
57-00-1

Creatinine

[Methyl-(10H-9-oxa-2,4-diaza-phenanthren-3-yl)-amino]-acetic acid
176717-37-6

[Methyl-(10H-9-oxa-2,4-diaza-phenanthren-3-yl)-amino]-acetic acid

Conditions
ConditionsYield
With sodium ethanolate In ethanol 1.) 15 min, 2.) reflux, 4 h;63%
6-(Dimethylaminomethylene)-2-cyclohexen-1-one

6-(Dimethylaminomethylene)-2-cyclohexen-1-one

Creatinine
57-00-1

Creatinine

[(5,6-dihydro-quinazolin-2-yl)-methyl-amino]-acetic acid

[(5,6-dihydro-quinazolin-2-yl)-methyl-amino]-acetic acid

Conditions
ConditionsYield
Stage #1: Creatinine With sodium ethanolate In ethanol at 20℃; for 0.25h; Metallation;
Stage #2: 6-(dimethylaminomethylene)cyclohex-2-en-1-one In ethanol for 10h; Cyclization; Heating;
62%

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