60222-69-7

Upstream product

• 100-02-7 4-nitro-phenol 
• 33036-62-3 4-Bromo-1-butanol 
• 110-63-4 Butane-1,4-diol 
• 350-46-9 4-Fluoronitrobenzene 
• 4224-62-8 6-chlorohexanoic acid 

Downstream Products

• 1427063-50-0 tris((4-nitrophenoxy)butyl) benzene-1,3,5-tricarboxylate 

Relevant academic research and scientific papers

Novel pazopanib derivatives and pharmaceutical composition comprising the same

The present invention relates to novel pazopanib derivatives or a salt thereof having inhibition activities of angiogenesis and epidermal growth factors at the same time, and to a pharmaceutical composition comprising the same as an active ingredient. The pazopanib derivatives have inhibition activities of angiogenesis and epidermal growth factors at the same time unlike pazopanib, thereby more effectively treating and preventing EGFR-related cancer diseases such as lung cancer, colon cancer or breast cancer through a multiple aim target, and effectively treating and preventing non-small-cell lung cancer which Iressa or Tarceva cannot have an effect on.COPYRIGHT KIPO 2017

Method for preparing initiating agent monomer containing azobenzene structure

The invention discloses an azobenzene compound and a synthesis method thereof.The synthesis method in the technical scheme includes the steps that 4-nitrophenol, halohydrin and potassium hydroxide serve as raw materials to synthesize p-nitrobenzene oxygen alcohol; the p-nitrobenzene oxygen alcohol, iron powder and ammonium chloride are reacted to obtain p-aminophenyl oxygen alcohol; a typical diazo coupling reaction is carried out to obtain solid product 4-acrylic acid (N-methyl amino) ethyl alcohol-4'-aminoethanol-azobenzene; the products, 2-bromoisobutyryl bromide and triethylamine are reacted to obtain the final product 4-acrylic acid (N-methyl amino) ethyl alcohol-4'-bromoisobutyric acid alcohol ester base-azobenzene, and washing and vacuum drying are carried out.The azo compound contains azobenzene photochromic groups, carbon-carbon double bonds and active-tail-end bromine atoms at the same time, can serve as a self-trigger monomer to synthesize branched polymers containing the functional azobenzene structures with the atom transfer radical polymerization (ATRP) method, and has potential application photoresponse polymers.

Star mesogens-Synthesis and structural characterization using 1D and 2D solution NMR techniques and mesophase characterization

Novel star mesogens based on trimesic acid and symmetrical side arm cores with terminal alkoxy groups were synthesized via a divergent approach. The central core and side arms were connected through alkyl spacers. All the synthesized mesogens and their intermediates were characterized thoroughly using Fourier transform infrared (FT-IR), 1H nuclear magnetic resonance (NMR), 13C NMR, and mass spectrometers. One representative mesogen was subjected to the two-dimensional (2D) NMR experiments to ascertain the structure of the mesogens. The mesophase characterization was carried out using hot-stage optical polarizing microscopy (HOPM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) techniques. Many of the molecules with an ethyloxy spacer were found to be nonmesogenic, whereas all the molecules with a butyloxy spacer showed liquid crystalline phases. The increase of terminal chain length decreased the transition temperatures. The nematic phase was observed for the mesogens with short terminal chain length, whereas smectic polymorphism was observed on increasing the terminal chain length. The results of a variable temperature powder X-ray diffraction of the representative sample support the smectic layer ordering.

DRUG-POLYMER CONJUGATES

This invention relates to a polypeptide-polymer conjugate that includes a polypeptide moiety, a polyalkylene oxide moiety, a linker connecting the polypeptide moiety with the polyalkylene oxide moiety, a first linkage between the polypeptide moiety and th

Solvent polarity across weakly associating interfaces

Molecular ruler surfactants, solvatochromic probes of solvent polarity, have been used to examine changes in solvent polarity across weakly associating liquid/liquid interfaces. The water/alkane interfaces were formed between an aqueous subphase and either cyclic (cyclohexane and methylcyclohexane) or linear (octane and hexadecane) alkanes. Resonance-enhanced second-harmonic generation was used to collect effective excitation spectra of species adsorbed to these interfaces. As surfactants lengthened, the surfactant probe sampled an increasingly nonpolar environment as evidenced by an excitation wavelength that shifted toward the alkane limit. Data suggest that all four water/alkane interfaces are molecularly sharp (9 Aì?), but that differences in the solvent molecular structure alter the transition from aqueous to organic solvation across the interface. Polarity across two interfaces (cyclohexane and hexadecane) changes gradually over the distance spanned by ruler surfactants. In contrast, the transitions at the interfaces between water and methylcyclohexane and octane appear much more abrupt. These findings appear to correlate with each organic solvent's ability to pack and associated free volume. More free volume in the organic phase leads to a more abrupt water/alkane interface. Results are interpreted on the basis of recent molecular dynamics simulations examining polarity at different water/monolayer interfaces.

Molecular rulers: New families of molecules for measuring interfacial widths

Homologous series of solvatochromic neutral alcohols and ionic sulfates are synthesized and characterized. Each surfactant series consists of hydrophobic, p-nitroanisole-based chromophores attached to polar or ionic headgroups by n-alkyl spacers. UV absorption measurements show that the optical properties of surfactant chromophores closely track those of the parent chromophore. Interfacial tension measurements are used to calculate surface excess concentrations of ionic surfactants adsorbed to an aqueous-cyclohexane interface. With a hydrophobic chromophore, a hydrophilic headgroup, and a variable-length, alkyl spacer, these surfactants have the potential to function as molecular rulers: probes of molecular-scale variation in solvation forces across condensed-phase interfaces. Changing the separation between the hydrophobic, solvatochromic probe and the hydrophilic headgroup should enable different members of a homologous series to span different interfacial widths, thus exposing the chromophore to different chemical environments. This idea is explored by using surface-specific, nonlinear optical spectroscopy. Resonant second harmonic spectra of p-nitroanisole and the surfactant product 4a adsorbed to an aqueous-cyclohexane interface show the surfactant spectrum blue-shifted 9 nm relative to the spectrum of adsorbed p-nitroanisole. On the basis of chromophore solvatochromism, these results are consistent with a less polar environment surrounding the surfactant chromophore. Significant differences in interfacial solvation resulting from a ～5 A separation between the surfactant headgroup and chromophore support recently proposed models of molecularly sharp, microscopically flat aqueous-alkane interfaces.

Benzamidine derivatives

The present invention relates to benzamidine derivatives corresponding to the general formula STR1 in which: A represents a linear or branched alkyl chain containing from 3 to 9 carbon atoms; and X represents the oxygen atom or a direct bond, with the restriction that if X represents a direct bond, the benzamidine and the alkanol group are located in the para position, and also the pharmaceutically acceptable salts of the products of the formula (I); it also relates to a process for the preparation of the products of the formula (I) and the drugs for external use which contain a product of the formula (I).