60246-77-7

Basic information

• Product Name: 2-(4-methoxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine
• Synonyms: 1,5-Benzothiazepine, 2,3-dihydro-2-(4-methoxyphenyl)-4-phenyl-; 2-(4-Methoxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine; 2-(4-Methoxy-phenyl)-4-phenyl-2,3-dihydro-benzo[b][1,4]thiazepine; Methyl 4-(4-phenyl-2,3-dihydro-1,5-benzothiazepin-2-yl)phenyl ether
• CAS NO: 60246-77-7
• Molecular Formula: C₂₂H₁₉NOS
• Molecular Weight: 345.4574
• Mol File: 60246-77-7.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 500.5°C at 760 mmHg
• Flash Point: 256.5°C
• Density: 1.16g/cm³
• Vapor Pressure: 1.17E-09mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: 2-(4-methoxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine(60246-77-7)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine(60246-77-7)

Safety Data

• Hazardous Substances Data: 60246-77-7(Hazardous Substances Data)

Usage

Molecular structure

2-(4-Methoxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine has a complex molecular structure that includes a methoxyphenyl group, a phenyl group, and a dihydrobenzothiazepine ring.

Classification

It belongs to the benzothiazepine class of compounds, which are known for their pharmacological properties.

Therapeutic applications

Benzothiazepines have been studied for their potential therapeutic applications, including their effects on the central nervous system and their potential as calcium channel blockers.

Further research needed

The specific properties and potential uses of 2-(4-Methoxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine would need to be further investigated in clinical and laboratory research.

Upstream product

• 98-86-2 acetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 137-07-5 2-amino-benzenethiol 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 
• 60246-64-2 β-(2-Aminophenylmercapto)-β-phenyl-propiophenone 
• 40358-31-4 2,3-dihydro-2,4-diphenyl-1,5-benzothiazepine 
• 1155-00-6 bis(2-nitrophenyl)disulfide 
• 22252-15-9 trans-4-methoxychalcone 

Downstream Products

• 1307301-59-2 ethyl 3a,4-dihydro-3,3a-diphenyl-5-(4-methoxyphenyl)-5H-[1,2,4]triazolo[5,4-d][1,5]benzothiazepine-1-carboxylate 
• 1307301-61-6 ethyl 3a,4-dihydro-3-(4-methylphenyl)-3a-phenyl-5-(4-methoxyphenyl)-5H-[1,2,4]triazolo[5,4-d][1,5]benzothiazepine-1-carboxylate 
• 1307301-60-5 ethyl 3a,4-dihydro-3-(4-chlorophenyl)-3a-phenyl-5-(4-methoxyphenyl)-5H-[1,2,4]triazolo[5,4-d][1,5]benzothiazepine-1-carboxylate 
• 166273-70-7 2-(4-Methoxy-phenyl)-4-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepine 

Relevant articles and documents

Catalyst-free synthesis of 2,3-dihydro-1,5-benzothiazepines in a renewable and biodegradable reaction medium

A clean and efficient strategy for the synthesis of benzothiazepines from chalcone and ortho-aminothiophenol has been reported. Here, glycerol, a biodegradable and reusable promoting medium, has been utilized under acid, base or metal-free conditions. The

Efficient and eco-friendly syntheses of 1,5-benzothiazepines and 1,5-benzodiazepines catalyzed by [Hmim][NO3] under mild conditions

This article presents a synthetic method and reaction mechanism of the 1,5-benzothiazepines and 1,5-benzodiazepines derivatives. In this research, 36 thiazepines and diazepines (mostly new) with a new method have been prepared and their structures have been characterized by spectroscopic methods. Crystal structures of a new thiazepine and diazepine (seven-membered rings) have also been determined and compared with thiazine (six-membered ring). In this method, N-methylimidazolium nitrate [Hmim][NO3] has been used as a catalyst that acts as an environmental friendly system.

Synthesis and structure characterization of new [1,2,4]triazolo[5,4-d][1,5] benzothiazepine derivatives through 1,3-dipolar cycloaddition reaction

Reaction of 1,5-benzothiazepines 3, obtained from chalcones 2 and o-aminobenzenthiol, with the (phenylhydrazino) chloromethylenecarboxylates 4 in the presence of Et3N leads to a series of new [1,2,4]triazolo[5,4-d] [1,5]benzothiazepine derivatives 5. Their structures were established using spectroscopic methods and that of compound 5d was confirmed using X-ray diffraction analysis.