60310-07-8Relevant articles and documents
3-OXO-1,4-DIAZEPINYLE COMPOUNDS AS NRF2 ACTIVATORS
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Page/Page column 52, (2018/07/05)
The present invention relates to bisaryl lactam compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the compounds of this invention include a compound of Formula (I):
NRF2 REGULATORS
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Page/Page column 49, (2017/01/02)
The present invention relates to aryl analogs Formula (I), pharmaceutical compositions containing them and their use as Nrf2 regulators.
NRF2 REGULATORS
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Page/Page column 126, (2017/01/02)
Provided are aryl analogs，pharmaceutical compositions containing them and their use as NRF2 regulators.
NRF2 REGULATORS
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Page/Page column 73, (2015/07/07)
The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
KAT II INHIBITORS
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Page/Page column 37, (2012/06/16)
The present invention relates to compounds 3-amino-1-hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline-7-carbonitrile, 3-amino-1-hydxoxy-7-(2-methoxyethoxy)-3,4-dihydro-quinolin-2(1H)-one, and 3-amino-1-hydroxy-7-[(1S)-2-methoxy-1-methylethoxy]-3,4-dihydroquinolin-2(1H)-one, including racemic mixtures and resolved enantiomers thereof, to pharmaceutically acceptable salts thereof, and to the treatment of cognitive deficits associated with schizophrenia and other psychiatric, neurodegenerative and/or neurological disorders in mammals, including humans
Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents
Ahmad, Saleem,Ngu, Khehyong,Miller, Keith J.,Wu, Ginger,Hung, Chen-pin,Malmstrom, Sarah,Zhang, Ge,O'Tanyi, Eva,Keim, William J.,Cullen, Mary Jane,Rohrbach, Kenneth W.,Thomas, Michael,Ung, Thao,Qu, Qinling,Gan, Jinping,Narayanan, Rangaraj,Pelleymounter, Mary Ann,Robl, Jeffrey A.
scheme or table, p. 1128 - 1133 (2010/06/15)
Agonists of the 5-HT2C receptor have been shown to suppress appetite and reduce body weight in animal models as well as in humans. However, agonism of the related 5-HT2B receptor has been associated with valvular heart disease. Synthesis and biological evaluation of a series of novel and highly selective dihydroquinazolinone-derived 5-HT2C agonists with no detectable agonism of the 5-HT2B receptor is described. Among these, compounds (+)-2a and (+)-3c were identified as potent and highly selective agonists which exhibited weight loss in a rat model upon oral dosing.
Quinazolinone compounds
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, (2008/06/13)
Phosphate derivatives are disclosed of quinazolinone compounds having structural formula (I) or a pharmaceutically acceptable salt thereof, wherein X' represent hydroxyl, alkyl, alkoxy, or O-Z where Z is a phosphate or phosphate derivative; Y' represents
N-SUBSTITUTED IMIDAZOLE AND BENZIMIDAZOLE DERIVATIVES USEFUL AS ANGIOTENSON II ANTAGONISTS
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, (2008/06/13)
Compounds are disclosed having the formula STR1 These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
Certain 1H-pyrrold[3,4-b]quinolin-1-one-9-amino-2,3-dihydro derivatives useful for treating anxiety
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, (2008/06/13)
The present invention comprises certain quinoline lactams of formula I; pharmaceutically acceptable salts of the compounds of formula I; pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable salt thereof, for use in the treatment of anxiety; and processes for the manufacture of the compounds of formula I, as well as intermediates for use in such manufacture.
o-Nitroaniline Derivatives. Part 8. Synthesis of Some Unsymmetrical Dimethylquinoxalines: A Long-Standing Problem Resolved
Blaikley, David C.W.,Currie, David W,Smith, David M.,Watson, Susan A.,McNab, Hamish
, p. 367 - 369 (2007/10/02)
Reduction of N-acetonyl-4-methyl-2-nitro-N-p-tolylsulphonylaniline, using tin(II) chloride in hydrochloric acid, gives 2,7-dimethylquinoxaline (42percent) together with di-p-tolyl disulphide and toluene-p-thiol. 2,6- and 2,5-Dimethylquinoxalines are similarly obtained from the appropriately substituted nitroanilines; the 2,8-dimethyl isomer, however, is obtained impure and in very low yield.
