60348-60-9

Usage

Uses

Used in Consumer Electronics:
2,2',4,4',5-Pentabromodiphenyl ether is used as a flame retardant in consumer electronics to reduce the risk of fire, ensuring the safety of users and prolonging the lifespan of electronic devices.
Used in Textile Industry:
In the textile industry, 2,2',4,4',5-Pentabromodiphenyl ether is used as a flame retardant for fabrics, enhancing their fire resistance and providing additional safety for consumers in various applications such as upholstery, carpets, and clothing.
Used in Plastics Manufacturing:
2,2',4,4',5-Pentabromodiphenyl ether is utilized as a flame retardant in the production of plastics, improving their fire safety characteristics and reducing the likelihood of fire incidents in various plastic products.
However, due to the growing awareness of the potential health and environmental risks associated with 2,2',4,4',5-Pentabromodiphenyl ether, there is a global trend towards the development and adoption of alternative, safer flame retardants in these industries.

Upstream product

• 5436-43-1 2,2',4,4'-Tetrabromodiphenyl ether 
• 14401-61-7 2,4,5-tribromophenol 
• 615-58-7 2,4-dibromophenol 
• 615-54-3 1,2,4-tribromobenzene 
• 615-86-1 2,4,5-tribromoaniline 

Relevant academic research and scientific papers

Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathway

Polybrominated diphenyl ethers (PBDEs) have become widely distributed as environmental contaminants due to their use as flame retardants. Their structural similarity to other halogenated aromatic pollutants has led to speculation that they might share toxicological properties such as hepatic enzyme induction. In this work we synthesized a number of PBDE congeners, studied their affinity for rat hepatic Ah receptor through competitive binding assays, and determined their ability to induce hepatic cytochrome P-450 enzymes by means of EROD (ethoxyre-sorufin-O-deethylase) assays in human, rat, chick, and rainbow trout cells. Both pure PBDE congeners and commercial PBDE mixtures had Ah receptor binding affinities 10-2-10-5 times that of 2,3,7,8-tetrachlorodibenzo-p-dioxin. In contrast with polychlorinated biphenyls, Ah receptor binding affinities of PBDEs could not be related to the planarity of the molecule, possibly because the large size of the bromine atoms expands the Ah receptor's binding site. EROD activities of the PBDE congeners followed a similar rank order in all cells. Some congeners, notably PBDE 85, did not follow the usual trend in which strength of Ah receptor binding affinity paralleled P-450 induction potency. Use of the gel retardation assay with a synthetic oligonucleotide indicated that in these cases the liganded Ah receptor failed to bind to the DNA recognition sequence.

Synthesis and Characterization of Polybrominated Diphenyl Ethers - Unlabelled and Radiolabelled Tetra,- Penta- and Hexa-bromodiphenyl Ethers

Diphenyl ether, 3-bromodiphenyl ether and 3,3'-dibromodiphenyl ether have been synthesized via coupling of the appropriate phenol and bromobenzene.Each of these compounds was subsequently brominated to (i) 2,2',4,4'-tetrabromodiphenyl ether, (ii) 2,2'3,4,