14401-61-7

Basic information

• Product Name: 2,4,5-TRIBROMOPHENOL
• Synonyms: 2,4,5-TRIBROMOPHENOL;Phenol, 2,4,5-tribroMo-
• CAS NO: 14401-61-7
• Molecular Formula: C₆H₃Br₃O
• Molecular Weight: 330.79942
• Mol File: 14401-61-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 295.3 °C at 760 mmHg
• Flash Point: 132.4 °C
• Appearance: /
• Density: 2.424 g/cm³
• Vapor Pressure: 0.000876mmHg at 25°C
• Refractive Index: 1.674
• CAS DataBase Reference: 2,4,5-TRIBROMOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-TRIBROMOPHENOL(14401-61-7)
• EPA Substance Registry System: 2,4,5-TRIBROMOPHENOL(14401-61-7)

Safety Data

• Hazardous Substances Data: 14401-61-7(Hazardous Substances Data)

Usage

Uses

2,4,5-Tribromophenol is a standard for environmental testing and research. Determination of urinary bromophenols (BrPs) as potential biomarkers for human exposure to polybrominated di-Ph ethers (PBDEs) using gas chromatography-tandem mass spectrometry (GC-MS/MS). Study of the inhibitory potency of BDE-47 and BDE-99 towards CYP2B6-mediated metabolism of bupropion in human liver microsomes.

InChI:InChI=1/C6H3Br3O/c7-3-1-5(9)6(10)2-4(3)8/h1-2,10H

Upstream product

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• 7726-95-6 bromine 
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• 3147-55-5 3,5-dibromosalicylic acid 
• 108-95-2 phenol 
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• 855429-70-8 2,4,5-tribromophenyl acetate 
• 98-95-3 nitrobenzene 
• 56-23-5 tetrachloromethane 
• 57688-20-7 2,3,5-tribromo-6-hydroxy-benzoic acid 

Downstream Products

• 14400-94-3 2,3,4,6-tetrabromophenol 
• 68631-49-2 2,2',4,4',5,5'-hexabromobiphenyl ether 
• 725714-49-8 3,4,6-tribromo-2-nitro-anisole 
• 815578-59-7 3,4,6-tribromo-2-nitro-phenol 
• 25779-26-4 2,3,5-tribromo-1,4-benzoquinone 
• 207122-16-5 2,3,4,6-tetrabromophenyl 2,4,5-tribromophenyl ether 
• 60348-60-9 2,2',4,4',5-pentrabromodiphenyl ether 
• 95970-10-8 2,4,5-tribromo-anisole 

Related news

Quantum chemical and direct dynamic study on homogeneous gas-phase formation of PBDD/Fs from 2,4,5-TRIBROMOPHENOL (cas 14401-61-7) and 3,4-dibromophenol08/15/2019

2,4,5-Tribromophenol (2,4,5-TBP) and 3,4-dibromophenol (3,4-DBP) have the minimum number of Br atoms needed to form 2,3,7,8-PBDD/Fs, which are the most toxic among all 210 PBDD/F isomers. A mechanistic understanding of the formation of PBDD/Fs is a prerequisite for minimizing their emissions. In...detailed

Relevant articles and documents

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Polybrominated diphenyl ethers (BDEs); preparation of reference standards and fluorinated internal analytical standards

Four new difluorinated tetra- and pentabromo BDE internal standards for GC-MS/GC-ECD analysis, 2F-BDE 47, 2F-BDE 85, 2F-BDE 99 and 2F-BDE 119, have been prepared in 98-99.0% purity, mainly by coupling of the new tribromodifluorophenols (19-21) and symmetr

Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathway

Polybrominated diphenyl ethers (PBDEs) have become widely distributed as environmental contaminants due to their use as flame retardants. Their structural similarity to other halogenated aromatic pollutants has led to speculation that they might share toxicological properties such as hepatic enzyme induction. In this work we synthesized a number of PBDE congeners, studied their affinity for rat hepatic Ah receptor through competitive binding assays, and determined their ability to induce hepatic cytochrome P-450 enzymes by means of EROD (ethoxyre-sorufin-O-deethylase) assays in human, rat, chick, and rainbow trout cells. Both pure PBDE congeners and commercial PBDE mixtures had Ah receptor binding affinities 10-2-10-5 times that of 2,3,7,8-tetrachlorodibenzo-p-dioxin. In contrast with polychlorinated biphenyls, Ah receptor binding affinities of PBDEs could not be related to the planarity of the molecule, possibly because the large size of the bromine atoms expands the Ah receptor's binding site. EROD activities of the PBDE congeners followed a similar rank order in all cells. Some congeners, notably PBDE 85, did not follow the usual trend in which strength of Ah receptor binding affinity paralleled P-450 induction potency. Use of the gel retardation assay with a synthetic oligonucleotide indicated that in these cases the liganded Ah receptor failed to bind to the DNA recognition sequence.