60365-87-9

Basic information

• Product Name: 2-(S)-diphenylphosphinomethyl-N-methylpyrrolidine
• Synonyms: 2-(S)-diphenylphosphinomethyl-N-methylpyrrolidine
• CAS NO: 60365-87-9
• Molecular Weight: 283.353
• Mol File: 60365-87-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(S)-diphenylphosphinomethyl-N-methylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(S)-diphenylphosphinomethyl-N-methylpyrrolidine(60365-87-9)
• EPA Substance Registry System: 2-(S)-diphenylphosphinomethyl-N-methylpyrrolidine(60365-87-9)

Safety Data

• Hazardous Substances Data: 60365-87-9(Hazardous Substances Data)

Upstream product

• 147-85-3 L-proline 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 86661-32-7 (S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate 
• 135055-75-3 (S)-(-)-N-tert-butoxycarbonyl-2-<(diphenylphosphino)methyl>pyrrolidine 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 67824-38-8 (S)-(-)-1-methyl-2-chloromethylpyrrolidine hydrochloride 
• 829-85-6 diphenylphosphane 

Relevant articles and documents

Chiral aminophosphines as catalysts for enantioselective double-michael indoline syntheses

The bisphosphine-catalyzed double-Michael addition of dinucleophiles to electron-deficient acetylenes is an efficient process for the synthesis of many nitrogencontaining heterocycles. Because the resulting heterocycles contain at least one stereogenic center, this double-Michael reaction would be even more useful if an asymmetric variant of the reaction were to be developed. Aminophosphines can also facilitate the double-Michael reaction and chiral amines are more readily available in Nature and synthetically; therefore, in this study we prepared several new chiral aminophosphines. When employed in the asymmetric double-Michael reaction between ortho-tosylamidophenyl malonate and 3-butyn-2-one, the chiral aminophosphines produced indolines in excellent yields with moderate asymmetric induction.