65185-57-1

Upstream product

• 97456-85-4 [2-(2-Bromo-phenyl)-ethyl]-(2-iodo-benzyl)-amine; hydrochloride 
• 65185-58-2 2-(2-bromophenyl)ethanamine 
• 100-52-7 benzaldehyde 
• 26260-02-6 2-iodobenzaldehyde 
• 1093413-22-9 C₂₁H₁₉BrN₂O₄S 
• 2183-83-7 methanesulfonic acid 2-(2-bromophenyl)ethyl ester 
• 100-46-9 benzylamine 
• 1074-16-4 2-bromophenylethyl alcohol 
• 65185-68-4 o-bromonitrostyrene 
• 178809-24-0 (ortho-bromophenylacetyl)benzylamine 

Downstream Products

• 6037-73-6 1-benzyl-2,3-dihydro-1H-indole 
• 1109229-94-8 methyl benzyl[2-(2-bromophenyl)ethyl]carbamate 
• 1109229-95-9 2-benzyl-5-bromo-3,4-dihydroisoquinolin-1(2H)-one 
• 1109229-96-0 2-benzyl-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid 
• 1109229-92-6 2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide 
• 1109229-97-1 2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride 

Relevant academic research and scientific papers

1-OXO-ISOINDOLINE-4-CARBOXAMIDE AND 1-OXO-1,2,3,4-TETRAHYDROISOQUINOLINE-5-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF

The present invention relates to derivatives of 1-oxo-isoindoline-4-carboxamides and of 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamides, to the preparation thereof and to the therapeutic use thereof.

A mild inter- and intramolecular amination of aryl halides with a combination of CuI and CsOAc

A unique combination of CuI and CsOAc was found to catalyze aryl amination under mild conditions. The reaction takes place at room temperature or at 90 °C with broad functional group compatibility. The intramolecular reaction was able to form five-, six-, and seven-membered rings with various protecting groups on the nitrogen atom. The scope of the intermolecular amination, as well as its applications to unsymmetrical N,N′-dialkylated phenylenediamines, was investigated.

Fused cycloheptane and fused azacycloheptane compounds and their methods of use

The invention comprises novel compounds that are effective in the prophylaxis and treatment of diseases, such as integrin receptors mediated diseases, in particular, diseases or conditions mediated by integrin receptors, such as αvβ3, αvβ5, αvβ6and the like. The invention encompasses novel compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of such diseases and disorders. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.