60428-21-9Relevant academic research and scientific papers
Iron-catalyzed carbolithiation of alkynes having no heteroatoms
Shirakawa, Eiji,Ikeda, Daiji,Ozawa, Tsubasa,Watanabe, Shogo,Hayashi, Tamio
supporting information; experimental part, p. 1885 - 1887 (2009/10/17)
Alkyl- and aryllithium compounds were found to add to alkynes having no heteroatoms in the presence of an iron or iron-copper catalyst to give various trisubstituted vinyllithium compounds.
β-disubstituted allylic chlorides: Substrates for the Cu-catalyzed asymmetric SN2′ reaction
Falciola, Caroline A.,Tissot-Croset, Karine,Alexakis, Alexandre
, p. 5995 - 5998 (2007/10/03)
Scope broadened: A previously developed asymmetric Cu-catalyzed allylic substitution can be applied to more substituted allylic patterns. Two classes of β-disubstituted substrates, cinnamyl derivatives and aliphatic endocyclic allylic chlorides, afford excellent regio- and enantioselectivities (see schemes; L* = phosphoramidite ligand). (Chemical Equation Presented).
A general and stereoselective method for synthesis of tri- and tetrasubstituted alkenes
Macia?giewicz,Dybowski,Skowrońska
, p. 6057 - 6066 (2007/10/03)
A convenient, general and stereoselective synthesis of trisubstituted alkenes and tetrasubstituted alkenes containing a cyanide function as well as trisubstituted episulphides have been elaborated. Methodology described for the preparation of these compounds is based on the corresponding readily available selenophosphates 1 and thiophosphates 2.
Synthesis of trisubstituted and tetrasubstituted alkenes via a manganate-induced migration-elimination process
Kakiya, Hirotada,Shinokubo, Hiroshi,Oshima, Koichiro
, p. 10063 - 10069 (2007/10/03)
Preparation of alkenes via a manganate-induced alkylation-elimination sequence was investigated. The reaction of 2-alkoxy-1,1-dibromoalkanes with trialkylmanganates afforded disubstituted or trisubstituted alkenes. Treatment of 2-alkoxy-1,1,1-tribromoalkanes with trialkylmanganates provided trisubstituted or tetrasubstituted alkenes through bromine-metal exchange, transfer of two alkyl groups from manganese to carbon, and successive elimination of metal and the β-alkoxy moieties.
The Peterson olefination using the tert-butyldiphenylsilyl group: Stereoselective synthesis of di- and trisubstituted alkenes
Barbero,Blanco,Garcia,Pulido
, p. 1223 - 1228 (2007/10/03)
The reaction of α-tert-butyldiphenylsilyl carbonyl compounds with organometallics leads with a high diastereoselectivity to erythro-β-hydroxysilanes, which under acidic or basic elimination conditions give E or Z di- and trisubstituted alkenes.
Olefination reactions through phosphazenes
Perez,Ortiz
, p. 2029 - 2030 (2007/10/03)
The first synthesis of di-, tri- and tetrasubstituted alkenes through reaction of lithium P-diphenyl(alkyl)(N-carboxymethyl)phosphazenes with aldehydes and ketones is reported.
Alkyliron and Alkylcobalt Reagents, IV.- High Superiority of Me4CoLi2 and Me4FeLi2 in Comparison to Me2CuLi and Me4MnLi2 in Cross Coupling Reactions with Vinyl Bromides
Kauffmann, Thomas,Stach, Dirk
, p. 913 - 922 (2007/10/02)
The complexes Me4MLi2 (M = Co, Fe, Mn) and Me2CuLi (prepared in situ, but well-known in isolated form) were treated with a series of vinyl bromides.In nearly all cases Me4CoLi2 and Me4FeLi2 proved to by far the best methylating reagents (high yields, reaction at -78 deg C, short reaction time, no excess of the reagent necessary.These reagents will tolerate a hydroxy or cyano group in the substrate, whereas the classical reagent for methylation of vinyl bromides, Me2CuLi, is strongly inhibited by these groups.With the methylation of hydroxyvinyl bromides a new method was found for the synthesis of allyl alcohols. Key Words: Organocobalt complexes / Organoiron complexes
