604797-61-7

Basic information

• Product Name: 5-fluoro-2,3-diphenyl-1H-indole
• Synonyms: 5-fluoro-2,3-diphenyl-1H-indole
• CAS NO: 604797-61-7
• Molecular Weight: 287.336
• Mol File: 604797-61-7.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 5-fluoro-2,3-diphenyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-2,3-diphenyl-1H-indole(604797-61-7)
• EPA Substance Registry System: 5-fluoro-2,3-diphenyl-1H-indole(604797-61-7)

Safety Data

• Hazardous Substances Data: 604797-61-7(Hazardous Substances Data)

Upstream product

• 1352745-19-7 1-(5-fluoro-2,3-diphenyl-1H-indol-1-yl)ethan-1-one 
• 501-65-5 diphenyl acetylene 
• 61272-76-2 4-fluoro-2-iodoaniline 
• 887903-01-7 4-fluoro-2-trimethylsilanylethynylphenylamine 
• 887903-03-9 4-fluoro-2-ethynylaniline 
• 591-50-4 iodobenzene 
• 114-83-0 1-acetyl-2-phenylhydrazine 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 1202391-84-1 tert-butyl 2-(4-fluorophenyl)hydrazine-1-carboxylate 
• 350-46-9 4-Fluoronitrobenzene 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 108-86-1 bromobenzene 
• 371-40-4 4-fluoroaniline 
• 1268250-41-4 C₁₂H₁₂FNO₂ 

Relevant articles and documents

Rhodium-Catalyzed Annulation of N-Acetoxyacetanilide with Substituted Alkynes: Conversion of Nitroarenes to Substituted Indoles

A general and efficient rhodium-catalyzed redox-neutral annulation of N-acetoxyacetanilides, readily accessible from nitroarenes, with alkynes has been accomplished for the synthesis of substituted indole derivatives. A wide range of substituted 2,3-diarylindoles were achieved from various substituted N-acetoxyacetanilides and symmetrical/unsymmetrical alkynes in good to excellent yields. The developed method was successfully integrated with the synthesis of N-acetoxyacetanilides for the efficient one-pot synthesis of indoles from nitroarenes. The important features are the introduction of N-acetoxyacetamide as a new directing group, redox-neutral annulation, an additive-free approach, wide functional group tolerance, an intramolecular version, and a one-pot reaction of nitroarenes. The method was further extended to the synthesis of potent higher analogues of indole, viz., pyrrolo[3,2-f]indoles and dibenzo[a,c]carbazoles. In addition, a plausible mechanism was proposed based on the isolation and stoichiometric study of a potential aryl-Rh intermediate.

Arylation synthesis method for novel five-membered aromatic heterocycle and aromatic-ring five-membered aromatic heterocycle

The invention belongs to the technical field of organic synthesis and in particular relates to an arylation synthesis method for a five-membered aromatic heterocycle or an aromatic-ring five-memberedaromatic heterocycle under the participation of an arylhydrazine derivative serving as a novel arylation reagent. The method comprises the steps: adding a raw material and aroyl hydrazine into a reactor, and carrying out a reaction at 60-100 DEG C for 8-24h under the condition that an oxidant and a transition metal catalyst are added; after the reaction is ended, carrying out suction filtration, extracting a filtrate by using ethyl acetate, carrying out drying to obtain a crude product of a target compound, and carrying out column chromatography on silica gel to obtain a pure product of the target compound. The arylation synthesis method for the five-membered aromatic heterocycle or the aromatic-ring five-membered aromatic heterocycle is scientific and reasonable and has the advantages such as simplicity and convenience in operation, relatively high yield and simplicity in amplification and purification.

A palladium/carbon as catalyst preparation of indole compounds method (by machine translation)

The present invention provides a palladium/carbon as catalyst preparation of indole compounds method, aniline and its analogs in the palladium/carbon with the alkyne under the action of the catalytic cyclization reaction, to form the corresponding indoles. This method has the advantages of: simple preparation method, the raw material is cheap, high yield, without protection of inert gas, the reaction temperature is relatively mild. (by machine translation)