60506-35-6

Usage

Uses

Used in Agriculture and Horticulture:
Isoxafen is used as a herbicidal agent for controlling annual grasses and broadleaf weeds in various crops. It is applied in the cultivation of vegetables, fruits, ornamental plants, and turf to maintain a healthy and productive environment for the desired plants to thrive.
Used as a Pre-emergence Herbicide:
Isoxafen is utilized in a pre-emergence application, which means it is applied before the weeds germinate. This application method is effective in preventing the growth of unwanted plants by targeting them at an early stage of development.
Caution:
It is important to handle Isoxafen with care, as it can be toxic to aquatic organisms and may pose risks to non-target plants. Proper application and adherence to safety guidelines are essential to minimize potential harm to the environment and other plant species.

InChI:InChI=1S/C14H7N3O7/c18-13-9-3-1-2-4-10(9)14(19)15(13)24-12-6-5-8(16(20)21)7-11(12)17(22)23/h1-7H

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 70-34-8 2,4-Dinitrofluorobenzene 
• 584-48-5 2,4-dinitrobromobenzene 

Downstream Products

• 17508-17-7 O-(2,4-dinitrophenyl)hydroxylamine 
• 56150-02-8 1-amino-2-methyl-pyridinium 2,4-dinitro-phenolate 
• 1313726-18-9 1-amino-4-((tert-butyldimethylsilyloxy)methyl)pyridinium 2,4-dinitrophenolate 
• 51-28-5 2,4-Dinitrophenol 
• 99-57-0 2-hydroxy-5-nitroaniline 

Relevant academic research and scientific papers

SUBSTITUTED TETRAHYDROISOQUINOLINE ETHYLBENZAMIDE ANTI-CANCER AGENTS

The compounds herein disclosed are N-substituted tetrahydroisoquinoline ethylbenzamide compounds that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of N-substituted tetrahydroisoquinoline ethylbenzamide compounds have been shown to have anti-proliferative activity against cells. In particular, the compounds have been found to be effective in inhibiting the proliferation of cancer cells, such as cancer cells that originated in breast tissue. Additionally, it has been shown that the novel compounds have IC50 values against the breast cancer cells that are 6- to 10-fold less than the IC50 of Tamoxifen.

Visible Light as a Sole Requirement for Intramolecular C(sp3)-H Imination

A novel, simple, and practical visible-light-mediated intramolecular α-C(sp3)-H imination of tertiary aliphatic amines containing β-O-aryl oximes leading to N-heterocycles has been developed. The reaction was performed well at rt with tolerance of some functional groups. Importantly, the selective C-H functionalization did not require added catalyst, oxidant, additive, acid, and base; visible light was the sole requirement.

Enantioselective Synthesis of Chiral Oxime Ethers: Desymmetrization and Dynamic Kinetic Resolution of Substituted Cyclohexanones

Axially chiral cyclohexylidene oxime ethers exhibit unique chirality because of the restricted rotation of C=N. The first catalytic enantioselective synthesis of novel axially chiral cyclohexylidene oximes has been developed by catalytic desymmetrization of 4-substituted cyclohexanones with O-arylhydroxylamines and is catalyzed by a chiral BINOL-derived strontium phosphate with excellent yields and good enantioselectivities. In addition, chiral BINOL-derived phosphoric acid catalyzed dynamic kinetic resolution of α-substituted cyclohexanones has been performed and yields versatile intermediates in high yields and enantioselectivities.

POLYCYCLIC COMPOUND INCLUDING PYRAZOLE AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME

The present invention refers to pyrazole containing an alkali-soluble polymer resin compound including multi annular ring relates to organic light emitting device.

PYRAZOLE-BASED COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME

The present invention relates to a pyrazole-based compound and an organic light emitting device comprising the same. The organic light emitting device comprises a positive electrode, a negative electrode, and one or more layers of organic layers formed between the positive electrode and the negative electrode, wherein one or more layers of organic layers comprise the pyrazole-based compound.COPYRIGHT KIPO 2015

PYRAZOLE-BASED COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME

The present invention relates to a pyrazole-based compound and an organic light emitting device comprising the same. The organic light emitting device comprises a positive electrode, a negative electrode, and one or more organic layers formed between the positive electrode and the negative electrode, wherein the organic layers comprise the pyrazole-based compound.COPYRIGHT KIPO 2015

Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.

Elusive metal-free primary amination of arylboronic acids: Synthetic studies and mechanism by density functional theory

Herein, we disclose the first metal-free synthesis of primary aromatic amines from arylboronic acids, a reaction that has eluded synthetic chemists for decades. This remarkable transformation affords structurally diverse primary arylamines in good chemical yields, including a variety of halogenated primary anilines that often cannot be prepared via transition-metal-catalyzed amination. The reaction is operationally simple, requires only a slight excess of aminating agent, proceeds under neutral or basic conditions, and, importantly, can be scaled up to provide multigram quantities of primary anilines. Density functional calculations reveal that the most likely mechanism involves a facile 1,2-aryl migration and that the presence of an ortho nitro group in the aminating agent plays a critical role in lowering the free energy barrier of the 1,2-aryl migration step.