6052-64-8

Usage

Uses

Used in Organic Synthesis:
1,1,4-triphenylbut-3-en-1-ol is used as a building block for the synthesis of various organic compounds and pharmaceuticals due to its unique structure and reactivity.
Used in Pharmaceutical Industry:
1,1,4-triphenylbut-3-en-1-ol is used as a key intermediate in the development of pharmaceuticals, contributing to the creation of new drugs and therapeutic agents.
Used in Chemical Research:
1,1,4-triphenylbut-3-en-1-ol is utilized in chemical research for studying reaction mechanisms and exploring new synthetic pathways, further expanding the scope of organic chemistry.

Upstream product

• 119-61-9 benzophenone 
• 7664-41-7 ammonia 
• 108-88-3 toluene 
• 4392-24-9 Cinnamyl bromide 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 

Downstream Products

• 31067-15-9 1,1,4-triphenyl-1-butanol 

Relevant academic research and scientific papers

Zinc-mediated α-regioselective Barbier-type cinnamylation reactions of aldehydes, ketones and esters

We report a simple, efficient, and general method for the zinc-mediated regioselective cinnamylation of aldehydes and ketones under Barbier-type conditions in a one-pot synthesis affording the corresponding α-cinnamylated alcohols in moderate to excellent yields. Compared to the literature procedures, this approach is operationally simple, uses simple reactants, and provides direct access to linear α-cinnamylated alcohols with excellent regioselectivity. Experimental results suggest that the reactions proceed through the radical pathway. In addition, the reaction was found to be scalable to the gram-scale and the one-pot protocol is also applicable to less reactive esters leading to bishomoallylic alcohols which were valuable intermediates for desymmetrizing intramolecular Heck cyclization, allowing for the elaboration to functionalized building blocks.

Highly α-regioselective neodymium-mediated allylation of diaryl ketones

The first utility of neodymium as a mediating-metal in the highly α-regioselective Barbier reaction of diaryl ketones with allyl halides is reported in this paper. This reaction was conveniently carried out under mild conditions in a one-pot fashion with

α-Regioselective Barbier Reaction of Carbonyl Compounds and Allyl Halides Mediated by Praseodymium

The first utility of praseodymium as a mediating metal in the Barbier reaction of carbonyl compounds with allyl halides was reported in this paper. In contrast to the traditional metal-mediated or catalyzed Barbier reactions, exclusive α-adducts were obta

Pd-catalyzed nucleophilic allylic alkylation of aliphatic aldehydes by the use of allyl alcohols

Under catalysis of Pd(OAc)2-(P-n-Bu)3, Et 2Zn promotes a variety of allyl alcohols to undergo nucleophilic allylation of aliphatic aldehydes and ketones at room temperature and provides homoallyl alcohols in 60-90 and ca. 60% isolated yield, respectively. The reaction is irreversible and kinetically controlled, and unique regio- and stereoselectivities observed for the allylation with unsymmetrically substituted allyl alcohols are discussed.