60524-15-4

Basic information

• Product Name: 2-CHLORO-5-NITRONICOTINAMIDE
• Synonyms: 2-CHLORO-5-NITRONICOTINAMIDE;2-Chloro-5-nitro-3-Pyridinecarboxamide
• CAS NO: 60524-15-4
• Molecular Formula: C6H4ClN3O3
• Molecular Weight: 201.56726
• Mol File: 60524-15-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 320.7°Cat760mmHg
• Flash Point: 147.7°C
• Appearance: /
• Density: 1.61g/cm³
• Vapor Pressure: 0.000313mmHg at 25°C
• Refractive Index: 1.633
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-CHLORO-5-NITRONICOTINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-NITRONICOTINAMIDE(60524-15-4)
• EPA Substance Registry System: 2-CHLORO-5-NITRONICOTINAMIDE(60524-15-4)

Safety Data

• Hazardous Substances Data: 60524-15-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H4ClN3O3/c7-5-4(6(8)11)1-3(2-9-5)10(12)13/h1-2H,(H2,8,11)

Upstream product

• 10128-92-4 2-hydroxynicotinamide 
• 941083-49-4 C₆H₅N₃O₄ 
• 22280-56-4 2-chloro-3-methyl-5-nitropyridine 
• 21901-34-8 2-hydroxy-3-methyl-5-nitropyridine 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 42959-38-6 3-carboxy-2-chloro-5-nitro pyridine 
• 6854-07-5 2-hydroxy-5-nitropyridine-3-carboxylic acid 
• 609-71-2 2-hydroxy-3-carboxypyridine 
• 135795-55-0 2-chloro-3-chlorocarbonyl-5-nitropyridine 

Downstream Products

• 31309-08-7 2-chloro-5-nitropyridine-3-carbonitrile 

Relevant articles and documents

New 2-Thiopyridines as potential candidates for killing both actively growing and dormant mycobacterium tuberculosis cells

From in vivo observations, a majority of M. tuberculosis cells in latently infected individuals are in a dormant and probably nonculturable state, display little metabolic activity, and are phenotypically resistant to antibiotics. Despite many attempts, no specific antimicrobials effective against latent tuberculosis have yet been found, partly because of a lack of reliable and adequate in vitro models for screening of drug candidates. We propose here a novel in vitro model of M. tuberculosis dormancy that meets the important criteria of latency, namely, nonculturability of cells, considerable reduction of metabolic activity, and significant phenotypic resistance to the first-line antibiotics rifampin and isoniazid. Using this model, we found a new group of 2-thiopyridine derivatives that had potent antibacterial activity against both actively growing and dormant M. tuberculosis cells. By means of the model of M. tuberculosis nonculturability, several new 2-thiopyridine derivatives were found to have potent antitubercular activity. The compounds are effective against both active and dormant M. tuberculosis cells. The bactericidal effects of compounds against dormant M. tuberculosis was confirmed by using three different in vitro models of tuberculosis dormancy. The model of nonculturability could be used as a reliable tool for screening drug candidates, and 2-thiopyridine derivatives may be regarded as prominent compounds for further development of new drugs for curing latent M. tuberculosis infection.

Transformations of ortho-methoxyaryl(hetaryl)carboxamides into quinazolin-4-one and pyrido[2,3-d]pyrimidin-4-one derivatives

ortho-Chloroaryl(hetaryl)carboxamides containing one or two nitro groups at positions 3 and/or 5 of the ring undergo condensation accompanied by the pyrimidine ring closure on refluxing in an excess of sodium methoxide to form bicyclic products, viz., qui