60597-68-4

Basic information

• Product Name: 2-chloro-3-(pyrrolidin-1-ylcarbonyl)pyridine
• Synonyms: 2-chloro-3-(pyrrolidin-1-ylcarbonyl)pyridine;Albb-004242;2-chloro-3-(1-pyrrolidinylcarbonyl)pyridine(SALTDATA: FREE);(2-chloropyridin-3-yl)(pyrrolidin-1-yl)methanone;(2-chloro-3-pyridinyl)-1-pyrrolidinylmethanone;(2-Chloropyridin-3-yl);(pyrrolidin-1-yl)
• CAS NO: 60597-68-4
• Molecular Formula: C₁₀H₁₁ClN₂O
• Molecular Weight: 210.66
• Mol File: 60597-68-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 374.6 °C at 760 mmHg
• Flash Point: 180.3 °C
• Appearance: /
• Density: 1.3 g/cm³
• Vapor Pressure: 8.26E-06mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-chloro-3-(pyrrolidin-1-ylcarbonyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3-(pyrrolidin-1-ylcarbonyl)pyridine(60597-68-4)
• EPA Substance Registry System: 2-chloro-3-(pyrrolidin-1-ylcarbonyl)pyridine(60597-68-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 60597-68-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-(pyrrolidin-1-ylcarbonyl)pyridine is a chemical compound with the molecular formula C11H11ClN2O. It is a pyridine derivative that contains a chloro-substituted pyridine ring and a pyrrolidine moiety. 2-Chloro-3-(pyrrolidin-1-ylcarbonyl)pyridine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential applications in the development of new drugs, particularly in the field of neuroscience. Its pyrrolidine moiety makes it a valuable building block for the synthesis of molecules with diverse biological activities. Overall, 2-Chloro-3-(pyrrolidin-1-ylcarbonyl)pyridine is a versatile compound with potential applications in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C10H11ClN2O/c11-9-8(4-3-5-12-9)10(14)13-6-1-2-7-13/h3-5H,1-2,6-7H2

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 123-75-1 pyrrolidine 
• 49609-84-9 2-Chloronicotinoyl chloride 

Relevant articles and documents

N-Arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective α1-adrenoceptor antagonists

Novel arylpiperazines were identified as α1-adrenoceptor (AR) subtype- selective antagonists by functional in vitro screening. 3-[4-(ortho- Substituted phenyl)piperazin-1:yl]propylamines were derivatized with N,N- dimethyl anthranilamides, nicotinamides, as well as carboxamides of quinoline, 1,8-naphthyridine, pyrazolo[3,4-b]pyridine, isoxazolo[3,4- b]pyridine, imidazo[4,5-b]pyridine, and pyrazolo[1,5-a]pyrimidines. Strips of rabbit bladder neck were employed as a predictive assay for antagonism in the human lower tract. Rings of rat aorta were used as a 'negative screen' for the test antagonists. Binding to α1-ARs was relatively sensitive to size and electronic features of the arylpiperazine portion of the antagonists and permissive to these features on the heteroaryl carboxamide side. These structure-affinity findings were exploited to produce nicotinamides (e.g. 13ii and 25x) and pyrazolo[3,4-b]pyridines (e.g. 37f and 37y) ligands with nanomolar affinity at the α1-AR subtype prevalent in the human lower urinary tract (pA2 values: 8.8, 10.7, 9.3, and 9.9, respectively) and displaying 2-3 orders of magnitude selectivity over the α(1D)-AR.