606-55-3Relevant articles and documents
A coumarin-quinolinium-based fluorescent probe for ratiometric sensing of sulfite in living cells
Tan, Li,Lin, Weiying,Zhu, Sasa,Yuan, Lin,Zheng, Kaibo
, p. 4637 - 4643 (2014)
Based on a novel coumarin-quinolinium platform, probe 2 was rationally designed and synthesized as a novel ratiometric fluorescent sensor for sulfite anions. The probe exhibited a wide dynamic concentration range for sulfite anions in a PBS buffer (containing 1 mg mL-1 BSA). More importantly, the probe was suitable for ratiometric fluorescence imaging in living cells with high sensitivity, favorable selectivity, and minimal cytotoxicity. This journal is
Real-time imaging of alkaline phosphatase activity of diabetes in mice via a near-infrared fluorescent probe
Wang, Wen-Xin,Jiang, Wen-Li,Guo, Hong,Li, Yongfei,Li, Chun-Yan
, p. 480 - 483 (2021)
A novel water-soluble near-infrared fluorescent probe named QX-P with simple synthesis is developed. QX-P has high sensitivity and selectivity to ALP. Moreover, the probe can not only visualize ALP activity in four cell lines, but also real-time image ALP activity during the diagnosis and treatment of diabetes in mice.
A single small molecule fluorescent probe for imaging RNA distribution and detecting endogenous SO2through distinct fluorescence channels
Lin, Weiying,Liu, Yong,Wang, Weishan,Wang, Zhaomin,Zhao, Chang
, p. 19812 - 19817 (2021/11/12)
Fluorescent probes are a powerful tool in biological and biochemical fields. Herein, we prepared a new small molecule fluorescent probePYQUas a robust tool that can explore the interaction between RNA and SO2in biological environments. The probePYQUcould detect SO2and RNA by a change in green and red fluorescence, respectively. Besides, the probePYQUhas excellent properties, such as low biological toxicity, good membrane permeability, and high selectivity.PYQUwas used to detect SO2in living cells and zebrafish in the green channel and visualize endogenous RNA of cells with a deep red fluorescence signal. Therefore, we believe that the probePYQUis a valuable, robust, and reliable tool for studies of RNA and SO2
An Activatable AIEgen Probe for High-Fidelity Monitoring of Overexpressed Tumor Enzyme Activity and Its Application to Surgical Tumor Excision
Baek, Gain,Chung, Jeewon,Fan, Jiangli,Ge, Haoying,Hillman, Prima Fitria,Kim, Dayeh,Lee, Eun Young,Li, Haidong,Li, Yueqing,Nam, Sang-Jip,Peng, Xiaojun,Wang, Jingyun,Wu, Xiaofeng,Xu, Feng,Yao, Qichao,Yoon, Juyoung
supporting information, p. 10186 - 10195 (2020/03/23)
Monitoring fluctuations in enzyme overexpression facilitates early tumor detection and excision. An AIEgen probe (DQM-ALP) for the imaging of alkaline phosphatase (ALP) activity was synthesized. The probe consists of a quinoline-malononitrile (QM) core decorated with hydrophilic phosphate groups as ALP-recognition units. The rapid liberation of DQM-OH aggregates in the presence of ALP resulted in aggregation-induced fluorescence. The up-regulation of ALP expression in tumor cells was imaged using DQM-ALP. The probe permeated into 3D cervical and liver tumor spheroids for imaging spatially heterogeneous ALP activity with high spatial resolution on a two-photon microscopy platform, providing the fluorescence-guided recognition of sub-millimeter tumorigenesis. DQM-ALP enabled differentiation between tumor and normal tissue ex vivo and in vivo, suggesting that the probe may serve as a powerful tool to assist surgeons during tumor resection.
