606129-44-6

Upstream product

• 139519-25-8 Boc-L-Asp(β-methyl)-N-hydroxysuccinimide 
• 136703-59-8 (3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid methyl ester 
• 59768-74-0 (S)-2-t-butoxycarbonylaminosuccinic acid 4-methyl ester 
• 869212-63-5 methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-(tert-butyldiphenylsilyloxy)butanoate 
• 606129-43-5 [(S)-1-(((tert-butyldiphenyl)silanyl)oxymethyl)-3-hydroxypropyl]carbamic acid tert-butyl ester 

Downstream Products

• 869212-64-6 8-(tert-butyl-diphenyl-silanyloxymethyl)-2-hydroxymethyl-1-oxa-7-aza-spiro[5.5]undecane-7-carboxylic acid tert-butyl ester 
• 869212-62-4 [1-(tert-butyl-diphenyl-silanyloxymethyl)-8-(2,2-dimethyl-[1,3]dioxolan-4-yl)-5-oxo-octyl]-carbamic acid tert-butyl ester 
• 848643-99-2 {(S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-[3-(4-chloro-phenylsulfinyl)-azetidin-1-yl]-propyl}-carbamic acid tert-butyl ester 
• 848644-02-0 {(S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-propyl}-carbamic acid ter-butyl ester 

Relevant academic research and scientific papers

Orthogonally protected glycerols and 2-aminodiols: Useful building blocks in heterocyclic chemistry

The efficient synthesis of orthogonally protected glycerols, 2-aminopropane-1,3-diols and 2-aminobutane-1,4-diols that can constitute useful tools in heterocyclic chemistry, is reported. These interesting tri-functionalized small synthons were easily prepared from serine or aspartic acid. In addition, these substrates can be readily transformed into their iodide derivatives in very good yields. ARKAT USA, Inc.

A rapid access to the spiroaminoketal framework

A convergent and stereoselective synthesis of 1-oxa-7-azaspiro[5.5]undecane is described. This functional new spiroheterocycle is readily available from acetone N,N-dimethylhydrazone via a double alkylation and subsequent spiroannulation process. Georg Thieme Verlag Stuttgart.

1,3-DISUBSTITUTED AZETIDINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES

Compounds of formula Ia or Ib in free or salt form, wherein Ar, X1, X2, m, R1, Q, Y, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by CCR-3, for example an inflammatory or allergic cond