869212-62-4

Upstream product

• 606129-43-5 [(S)-1-(((tert-butyldiphenyl)silanyl)oxymethyl)-3-hydroxypropyl]carbamic acid tert-butyl ester 
• 869212-63-5 methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-(tert-butyldiphenylsilyloxy)butanoate 
• 606129-44-6 tert-butyl N-[(1S)-1-[(tert-butyldiphenylsilyloxy)methyl]-3-iodopropyl]carbamate 
• 67987-67-1 (4S)-4-(2-iodoethyl)-2,2-dimethyl-1,3-dioxolane 
• 59768-74-0 (S)-2-t-butoxycarbonylaminosuccinic acid 4-methyl ester 
• 136703-59-8 (3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid methyl ester 
• 139519-25-8 Boc-L-Asp(β-methyl)-N-hydroxysuccinimide 

Downstream Products

• 869212-64-6 8-(tert-butyl-diphenyl-silanyloxymethyl)-2-hydroxymethyl-1-oxa-7-aza-spiro[5.5]undecane-7-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

A rapid access to the spiroaminoketal framework

A convergent and stereoselective synthesis of 1-oxa-7-azaspiro[5.5]undecane is described. This functional new spiroheterocycle is readily available from acetone N,N-dimethylhydrazone via a double alkylation and subsequent spiroannulation process. Georg Thieme Verlag Stuttgart.