606137-93-3

Upstream product

• 582-24-1 1-phenyl-2-hydroxyethanone 
• 62861-51-2 phenacyl trifluoromethanesulfonate 
• 903877-33-8 3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2,2-dichloro-3-phenyl-cyclobutanone 
• 606137-78-4 1-[(R)-1-(2-Phenyl-allyloxy)-ethyl]-3,5-bis-trifluoromethyl-benzene 
• 530441-99-7 2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethanone 
• 606137-92-2 3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-tert-butoxycarbonylamino-3-phenyl-cyclobutanecarboxylic acid 
• 74-89-5 methylamine 
• 606137-19-3 2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2-phenyl-5,7-diaza-spiro[3.4]octane-6,8-dione 
• 606137-09-1 3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutanone 

Relevant academic research and scientific papers

Cyclobutane derivatives as potent NK1 selective antagonists

A series of novel cyclobutane derivatives as potent and selective NK1 receptor antagonists is described. Several compounds in this series exhibited high in vitro binding affinity (Ki {less-than or slanted equal to} 1 nM), and potent