60651-97-0

Upstream product

• 41345-72-6 3-(acetylthio)propanoyl chloride 
• 108395-22-8 octahydro-1H-isoindole-1-carboxylic acid hydrochloride 
• 67-56-1 methanol 
• 96016-96-5 1,3-Dihydro-2H-isoindole-1-carboxylic Acid Hydrochloride 

Downstream Products

• 444607-92-5 2-(tert-butyl) 1-methyl isoindoline-1,2-dicarboxylate 
• 914298-94-5 2-(5-chloro-2,4-bis-methoxymethoxybenzoyl)-2,3-dihydro-1H-isoindole-1-carboxylic acid methyl ester 
• 96017-14-0 Dimethyl 3-Benzyl-5H-pyrrolo<2,1-a>isoindole-1,2-dicarboxylate 
• 96017-13-9 Dimethyl 3-Phenyl-5H-pyrrolo<2,1-a>isoindole-1,2-dicarboxylate 
• 96017-02-6 1,3-Dihydro-2-phenylacetyl-2H-isoindole-1-carboxylic Acid 
• 96017-01-5 2-Benzoyl-1,3-dihydro-2H-isoindole-1-carboxylic Acid 
• 96016-98-7 Methyl 1,3-Dihydro-2-phenylacetyl-2H-isoindole-1-carboxylate 
• 96016-97-6 Methyl 1,3-Dihydro-2-benzoyl-2H-isoindole-1-carboxylate 
• 96016-96-5 1,3-Dihydro-2H-isoindole-1-carboxylic Acid Hydrochloride 

Relevant academic research and scientific papers

BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AGONISTS.

This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds include those according to formula 1, or a salt thereof, wherein Q, R1 , R2, R3 and R4 are as defined herein.

SUBSTITUTED ACYL DERIVATIVES OF OCTAHYDRO-1H-ISOINDOLE-1-CARBOXYLIC ACIDS

Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acid compounds and the pharmaceutically acceptable salts thereof are produced by acylating a suitably substituted octahydro-1H-isoindole with a suitably activated substituted carboxylic acid and when desired hydrolyzing the resulting product. The compounds of the invention, their salts and pharmaceutical compositions thereof are useful as antihypertensive agents.