60686-79-5

Basic information

• Product Name: Benzeneacetic acid, a-bromo-, (R)-
• CAS NO: 60686-79-5
• Molecular Formula: C8H7BrO2
• Molecular Weight: 215.046
• Mol File: 60686-79-5.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, a-bromo-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-bromo-, (R)-(60686-79-5)
• EPA Substance Registry System: Benzeneacetic acid, a-bromo-, (R)-(60686-79-5)

Safety Data

• Hazardous Substances Data: 60686-79-5(Hazardous Substances Data)

Upstream product

• 4870-65-9 2-bromophenylacetic acid 
• 875-74-1 (R)-phenylglycine 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 1268613-73-5 C₁₂H₁₁BrN₂O 
• 1268613-62-2 C₁₁H₈Br₂N₂O 
• 889804-68-6 C₁₀H₈BrN₃O 
• 530091-82-8 (+/-)-2-bromo-2-phenylacetic acid octyl ester 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 74004-88-9 2-bromo-2-phenylacetic acid benzyl ester 
• 181026-82-4 1,1-bis(trimethylsilyloxy)-2-bromo-2-phenylethene 

Downstream Products

• 2935-35-5 (S)-2-phenylglycine 
• 611-71-2 MANDELIC ACID 
• 875-74-1 (R)-phenylglycine 
• 103616-08-6 (S)-2-mercapto-2-phenylacetic acid 
• 646058-06-2 (S)-2-dodecylthiophenylacetic acid 
• 103-82-2 phenylacetic acid 
• 99853-94-8 chloro-phenyl-acetic acid allyl ester 
• 39925-39-8 (S)-phenyl-sulfo-acetic acid 
• 611-71-2 (R)-Mandelic Acid 
• 17199-29-0 (S)-Mandelic acid 
• 3966-32-3 (R)-methoxyphenylacetic acid 

Relevant articles and documents

Substituted α-mercaptoketones, new types of specific neprilysin inhibitors

New neprilysin inhibitors containing an α-mercaptoketone HSC(R1R2)CO group, as zinc ligand were designed. Two parameters were explored for potency optimization: the size of the inhibitor which could interact with the S1, S

A variant of Yarrowia lipolytica lipase with improved activity and enantioselectivity for resolution of 2-bromo-arylacetic acid esters

A variant of Lip2p lipase from Yarrowia lipolytica yeast was used for the resolution of 2-bromophenyl and o-tolyl acid esters, an important class of chemical intermediates for the pharmaceutical industry. In comparison with wild-type Lip2p, this variant, which contains one single amino acid change in the active site of the enzyme, V232A, displayed an enantioselectivity enhanced by one order of magnitude for the resolution of 2-bromo-phenylacetic acid ethyl ester (E-value increased from 5.5 to 59 for wild-type and V232A, respectively) and by fourfold for the resolution of 2-bromo-o-tolylacetic acid ethyl ester (going from an E-value of 27 to 111 for the wild-type and V232A, respectively). A remarkable increase in reaction velocity was also observed for both compounds, as a result of a significant gain in reactivity towards the favoured (S)-enantiomer (3- and 16-fold increase for 2-bromo-phenylacetic and -o-tolylacetic acid ethyl esters, respectively). These results demonstrate the key role of the V232 amino acid in enantiomer recognition and selectivity.

PROCESSES FOR THE PRODUCTION OF OPTICALLY ACTIVE COMPOUNDS HAVING SUBSTITUENTS AT THE 2-POSITION

The present invention provides a process for producing an optically active compound having a thio group at the 2-position important for manufacturing medicines. An optically active compound having a hydroxyl group at the 2-position is chlorinated with inv