74004-88-9

Upstream product

• 19078-72-9 bromo(phenyl)acetyl chloride 
• 100-51-6 benzyl alcohol 
• 62173-99-3 benzyl 2-hydroxy-2-phenylacetate 
• 218792-82-6 α-diazo-α-phenylacetic acid benzyl ester 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 1063685-52-8 (S)-2-bromo-2-phenylacetic acid benzyl ester 
• 60686-79-5 (R)-2-bromo-2-phenylacetic acid 
• 60686-78-4 (+)-(S)-α-bromophenylacetic acid 
• 59509-46-5 [2-oxo-3-(2-phenyl-acetylamino)-azetidin-1-yl]-phenyl-acetic acid benzyl ester 
• 250370-84-4 (2S,1'R,5'R)-(+)-Benzyl 2-phenyl-2-(2'-azabicyclo[3.3.0]octan-2'-yl)acetate 
• 250370-85-5 (2R,1'R,5'R)-(-)-Benzyl 2-phenyl-2-(2'-azabicyclo[3.3.0]octan-2'-yl)acetate 

Relevant academic research and scientific papers

Unbalanced-Ion-Pair-Catalyzed Nucleophilic Fluorination Using Potassium Fluoride

An unbalanced ion pair promoter (e.g., tetrabutylammonium sulfate), consisting of a bulky and charge-delocalized cation and a small and charge-localized anion, greatly accelerates nucleophilic fluorinations using easy handling KF. We also successfully converted an inexpensive and commercially available ion-exchange resin to the polymer-supported ion pair promoter (A26–SO42–), which could be reused after filtration. Moreover, A26–SO42– can be used in continuous flow conditions. In our conditions, water is well-tolerated.

Bromination of α-Diazo Phenylacetate Derivatives Using Cobalt(II) Bromide

A method for the bromination of α-diazo phenylacetate derivatives using cobalt(II) bromide is described. This bromination reaction features a short reaction time, broad substrate scope, operational simplicity, acid-free conditions, and gram-scalability. (Figure presented.).