607-90-9

Usage

Uses

Used in Skincare Industry:
SALICYLIC ACID N-PROPYL ESTER is used as an active ingredient in skincare products for its anti-inflammatory, exfoliating, and antimicrobial properties. It helps to unclog pores, prevent acne, and treat various skin conditions by penetrating the skin and exfoliating the top layer.
Used in Acne Treatment Products:
SALICYLIC ACID N-PROPYL ESTER is used as a key component in acne treatment products to reduce inflammation, unclog pores, and prevent the formation of acne lesions. Its exfoliating action helps to remove dead skin cells and promote skin renewal, leading to clearer and healthier skin.
Used in Pharmaceutical Industry:
SALICYLIC ACID N-PROPYL ESTER may be used in pharmaceutical applications due to its anti-inflammatory, antimicrobial, and antifungal properties. It can be incorporated into formulations for treating various skin conditions and infections.
Used in Industrial Applications:
SALICYLIC ACID N-PROPYL ESTER may also find use in industrial applications, such as in the development of new materials or processes, due to its versatile chemical properties and potential for further research and development.

InChI:InChI=1/C10H12O3/c1-2-7-13-10(12)8-5-3-4-6-9(8)11/h3-6,11H,2,7H2,1H3

Upstream product

• 71-23-8 propan-1-ol 
• 69-72-7 salicylic acid 
• 627-13-4 propyl nitrate 
• 610-99-1 1-(2-Hydroxy-phenyl)-propan-1-on 
• 6640-69-3 1-(2-hydroxyphenyl)-2-methylpropan-1-one 
• 118-93-4 o-hydroxyacetophenone 
• 119-36-8 methyl salicylate 
• 56-23-5 tetrachloromethane 
• 108-95-2 phenol 
• 540-54-5 1-Chloropropane 
• 1809-21-8 di-n-propyl phosphonate 

Downstream Products

• 60715-41-5 1-isopropyl-2-phenoxybenzene 
• 87188-65-6 2-hydroxy-5-isopropyl-benzoic acid methyl ester 
• 52159-64-5 3-Isopropylsalicylic acid methyl ester 
• 52040-40-1 2-hydroxy-3,5-dinitro-benzoic acid propyl ester 
• 60310-03-4 2-acetoxy-benzoic acid propyl ester 
• 119-36-8 methyl salicylate 

Relevant academic research and scientific papers

Synthesis of Hydroxybenzoic Acids and Their Esters by Reaction of Phenols with Carbon Tetrachloride and Alcohols in the Presence of Iron Catalysts

Alkyl esters of hydroxy-, methoxy-, and ethoxybenzoic and cresotic acids have been synthesized by reaction of phenols, anisole, phenetole, and cresols with carbon tetrachloride and alcohols in the presence of iron catalysts.

DBU-Based Dicationic Ionic Liquids Promoted Esterification Reaction of Carboxylic Acid with Primary Chloroalkane Under Mild Conditions

Abstract: A series of DBU-based (DBU = 1, 8-diazabicyclo [5.4.0] undec-7-ene) dicationic ionic liquids with different anions were successfully synthesized by the reaction of DBU and 1, 6-dichlorohexane. Therein, the dicationic ionic liquid 1, 1′-(hexane-1, 6-diyl)bis(1, 8-diazabicyclo [5.4.0]undec-7-enium) dichlorine (IL-1) was successfully employed as an efficient catalyst in esterification reaction of carboxylic acids with primary chloroalkanes under mild conditions without any additional basic reagents. Moreover, the optimum catalyst could be efficiently reused for five times without any significant change on the catalytic effect. The improved protocol is not only efficient, but also green and pollution-free.

Efficient microwave-assisted esterification reaction employing methanesulfonic acid supported on alumina as catalyst

A rapid and efficient protocol assisted by microwave irradiation for the synthesis of esters using methanesulfonic acid (CH3SO3H) supported on Al2O3 (AMA) as catalyst and free of solvent is described. The products were obtained in good yields and purity, with reduced reaction time, and the process is simple and environmentally benign. Copyright

Enhancement of optical faraday effect of nonanuclear Tb(III) complexes

The effective magneto-optical properties of novel nonanuclear Tb(III) complexes with Tb-O lattice (specifically, [Tb9(sal-R) 16(μ-OH)10]+NO3-, where sal-R = alkyl salicylate (R = -CH3 (Me), -C2H 5 (Et), -C3H7 (Pr), or -C4H 9 (Bu)) are reported. The geometrical structures of these nonanuclear Tb(III) complexes were characterized using X-ray single-crystal analysis and shape-measure calculation. Optical Faraday rotation was observed in nonanuclear Tb(III) complexes in the visible region. The Verdet constant per Tb(III) ion of the Tb9(sal-Me) complex is 150 times larger than that of general Tb(III) oxide glass. To understand their large Faraday rotation, electron paramagnetic resonance measurements of Gd(III) complexes were carried out. In this Report, the magneto-optical relation to the coordination geometry of Tb ions is discussed.

SO3H-functionalized Bronsted acidic ionic liquids as efficient catalysts for the synthesis of isoamyl salicylate

Six Bronsted acidic ionic liquids (BAILs) composed of [HSO 4] were prepared, characterized, and used as catalysts of low dosage in the synthesis of isoamyl salicylate. The effects of various parameters such as the kind of BAILs, temperature, catalyst loading, and molar ratio of the reactants on the conversion of salicylic acid were also examined in detail. The results suggested that the catalytic performances of BAILs were of close relevance to their Hammett acidities. The SO3H-functionalized BAILs 1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate ([BSmim][HSO 4]) and N-(4-sulfonic acid) butyl triethylammonium hydrogen sulfate ([BSEt3N][HSO4]) of strong acidities exhibited excellently catalytic activities and selectivities in the esterification of salicylic acid with isoamyl alcohol. The fully optimized geometries of [BSmim][HSO4] and [BSEt3N][HSO4] further manifest that their strong acidities are derived from the strong interactions between the anion with the sulfonic acid group. In addition, it was found that [BSmim][HSO4] could be also recovered easily and used repetitively at least six times without obvious decline in activity and quantity.

Esterification of salicylic acid using Br?nsted acidic ionic liquid based on Keggin heteropoly acid

For the first time, a newwater stable Br?nsted acidic ionic liquid based on Keggin heteroployacid (HPA) was used as environmentally benign catalytic medium in the esterfication of salicylic acid with aliphatic alcohols, CnH2n+1OH (n = 1-5) and benzylic alcohols, RC6H4CH2OH (R = H, NO2, OCH3). This ionic liquid (IL) afforded excellent yield in both thermal conditions and microwave irradiation. Maximum yields were observed under microwave irradiation. Different reaction runs were conducted by varying the reaction parameters such as molar ratio of reactants, weight of the IL, and reaction period in order to optimize the reaction. The IL was easily recovered and reused many times. No significant loss in catalytic activity was observed on recycling.

PHARMACEUTICAL COMBINATIONS INCLUDING ANTI-INFLAMMATORY AND ANTIOXIDANT CONJUGATES USEFUL FOR TREATING METABOLIC DISORDERS

One aspect of the present invention is a pharmaceutical combination comprising (a) an anti-inflammatory agent/anti-oxidant agent conjugate; and (b) an insulin secretogogue, an insulin sensitizer, an alpha-glucosidase inhibitor, a peptide analog, or a combination thereof. Another aspect of the invention relates to methods of treating metabolic disorders with such conjugates.

Thiocarbonates as Anti-Inflammatory and Antioxidant Compounds Useful For Treating Metabolic Disorders

The invention is directed to thiocarbonate compounds of Formula (I)-(III) and methods of treating atherosclerosis, neuropathy, nephropathy, retinopathy, inflammatory disorders, COPD, cardiovascular diseases, metabolic disorders, type I diabetes mellitus, type II diabetes mellitus, LADA, Wolfram Syndrome 1, Wolcott-Rallison syndrome, metabolic syndrome, dyslipidemia, hyperglycemia, or insulin resistance. The compounds of the invention are also useful for protecting pancreatic beta-cells and for reducing free fatty acids, triglycerides, advanced glycated end products, ROS, lipid peroxidation, tissue and plasma TNFalpha and IL6 levels, or for delaying or preventing cardiovascular complications associated with atherosclerosis.

Catalytic performance of nano-SiO2-supported Preyssler heteropolyacid in esterification of salicylic acid with aliphatic and benzylic alcohols

An efficient and environmentally benign procedure for the catalytic esterification of salicylic acid with aliphatic alcohols, CnH 2n+1OH (n = 1-5) and benzylic alcohols, RC6H 4CH2OH (R = H, NO2, OCH3, Br, Cl, Me) was developed using nano-SiO2-supported Preyssler heteropolyacid both under thermal conditions and microwave irradiation. Silica nanostructures were obtained through a sol-gel method and were characterized by transmission electron microscopy and powder X-ray diffraction. The effects of various parameters such as solvent type, molar ratio of substrates, Preyssler heteropolyacid loading on silica, catalyst amount, temperature, and reaction time were studied and the optimum conditions were obtained. It has been found that the catalyst with 30 wt loading is highly active and shows high yields in esterification reactions. The use of nano-SiO2-supported Preyssler heteropolyacid coupled with microwave irradiation allows a solvent-free, rapid (3 min), and high-yielding reaction. This catalyst can be easily recovered and reused for many times without a significant loss in its activity.

Propanolysis of esters using chlorotrimethylsilane

A variety of methyl esters are converted into the corresponding propyl esters upon treatment with 1-propanol and chlorotrimethylsilane. Among them acyclic aliphatic esters have the best conversion rate.