627-13-4 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 627-13-4 differently. You can refer to the following data:
1. White to straw-colored liquid; ethereal
odor. Insoluble in water; soluble in alcohol
and ether.
2. n-Propyl nitrate is a colorless to pale yellow
liquid. Ethereal odor.
Physical properties
Colorless to light yellow, flammable liquid with an ether-like odor. Odor threshold concentration
is 50 ppm (quoted, Amoore and Hautala, 1983).
Uses
Different sources of media describe the Uses of 627-13-4 differently. You can refer to the following data:
1. Fuel ignition promoter; rocket propellants;
organic intermediate.
2. Fuel ignition promoter, in rocket fuel formulations, as organic intermediate.
General Description
A white to straw-colored liquid with an ether-like odor. About the same density as water and insoluble in water. Flash point 70°F. Vapors heavier than air. Used as a fuel. Shock sensitive. The shock sensitivity is removed by addition of 1-2% of propane, butane, chloroform, ethyl ether, or methyl ether.
Air & Water Reactions
Highly flammable. Insoluble in water.
Reactivity Profile
Organonitrates, such as n-Propyl nitrate, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. Nitroalkanes are milder oxidizing agents, but still react violently with reducing agents at higher temperature and pressures. Nitroalkanes react with inorganic bases to form explosive salts. The presence of metal oxides increases the thermal sensitivity of nitroalkanes. Nitroalkanes with more than one nitro group are generally explosive. Contact with either strong oxidizers or with combustibles may cause fires and explosions.
Hazard
Flammable, severe fire and explosion risk,
strong oxidizing material, explosive limits in air 2–
100%. Nausea and headache.
Health Hazard
Exposure can cause anoxia and cyanosis. Other effects are weakness, dizziness, and severe headaches.
Fire Hazard
Special Hazards of Combustion Products: Toxic gases and vapors, such as oxides of nitrogen and carbon monoxide, may be released in a fire.
Safety Profile
Poison by intravenous
route. Inhalation can cause hypotension and
methemoglobinemia. Dangerous fire hazard
when exposed to heat, flame, or oxidizers.
Explosive in the form of vapor when
exposed to heat or flame. A shock-sensitive
explosive. It can be desensitized by the
addition of 1-2% propane, butane,
chloroform, dunethyl ether, or dithyl ether.
When heated to decomposition it emits
toxic fumes of NOx. Used as a fuel ignition
promoter, chemical intermediate, and in the
manufacture of rocket fuels. See also
NITRATES and ESTERS.
Potential Exposure
Propyl nitrate has been used as an
intermediate as a rocket propellant and as an ignition
improver in diesel fuels.
Shipping
UN1865 n-Propyl nitrate, Hazard Class: 3;
Labels: 3-Flammable liquid.
Incompatibilities
Vapor may form explosive mixture with
air. Reacts with reducing agents, combustible materials;
may be violent. A shock-sensitive explosive. The shock
sensitivity is removed by addition of 1%?2% of propane,
butane, chloroform, ethyl ether, or methyl ether . May
explode on heating. Forms explosive mixtures with com-
bustible materials. This material is an organonitrate. They
can range from slight to strong oxidizing agents. If mixed
with reducing agents, including hydrides, sulfides, and
nitrides, they may begin a vigorous reaction that culminates
in a detonation. Nitroalkanes are milder oxidizing agents,
but still react violently with reducing agents at higher tem-
perature and pressures. Nitroalkanes react with inorganic
bases to form explosive salts. The presence of metal oxides
increases the thermal sensitivity of nitroalkanes.
Nitroalkanes with more than one nitro group are generally
explosive. Contact with either strong oxidizers or with
combustibles may cause fires and explosions .
Waste Disposal
Incineration: large quantities
of material may require nitrogen oxide removal by catalytic
or scrubbing processes . An alternative route suggested
involves pouring over soda ash, neutralizing with HCl and
flushing to the drain with water.
Check Digit Verification of cas no
The CAS Registry Mumber 627-13-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 627-13:
(5*6)+(4*2)+(3*7)+(2*1)+(1*3)=64
64 % 10 = 4
So 627-13-4 is a valid CAS Registry Number.
InChI:InChI=1/C3H7NO3/c1-2-3-7-4(5)6/h2-3H2,1H3
627-13-4Relevant articles and documents
NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
-
Page/Page column 123, (2020/11/12)
The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
Kinetics and Products of the Reactions of Ethyl and n-Propyl Nitrates with OH Radicals
Morin, Julien,Bedjanian, Yuri,Romanias, Manolis N.
, p. 822 - 829 (2016/11/02)
The kinetics of the reactions of ethyl (1) and n-propyl (2) nitrates with OH radicals has been studied using a low-pressure flow tube reactor combined with a quadrupole mass spectrometer. The rate constants of the title reactions were determined under pseudo–first-order conditions from kinetics of OH consumption in high excess of nitrates. The overall rate constants, k1 = 1.14 × 10?13 (T/298)2.45 exp(193/T) and k2 = 3.00 × 10?13 (T/298)2.50 exp(205/T) cm3 molecule?1 s?1 (with conservative 15% uncertainty), were determined at a total pressure of 1 Torr of helium over the temperature range (248–500) and (263–500) K, respectively. The yields of the carbonyl compounds, acetaldehyde and propanal, resulting from the abstraction by OH of an α-hydrogen atom in ethyl and n-propyl nitrates, followed by α-substituted alkyl radical decomposition, were determined at T = 300 K to be 0.77 ± 0.12 and 0.22 ± 0.04, respectively.
NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity
Fang, Lei,Appenroth, Dorothea,Decker, Michael,Kiehntopf, Michael,Lupp, Amelie,Peng, Sixun,Fleck, Christian,Zhang, Yihua,Lehmann, Jochen
supporting information; experimental part, p. 7666 - 7669 (2009/12/07)
A series of tacrine - NO donor hybrid compounds are synthesized and evaluated for cholinesterase inhibitory activity, cognition improving activity, and hepatotoxicity. The pharmacological results indicate that hybrid compounds 1, 2, and 3a potently inhibit cholinesterase in vitro and significantly improve the scopolamine-induced cognition impairment, whereas an analogue (3h) of 2 without the NO donor moiety does not. Compared to tacrine, 1 and 2 show much less hepatotoxicity. Molecular modeling studies suggest that 2 may interact with the catalytic and the peripheral anionic site of acetylcholinesterase.
