60708-99-8Relevant academic research and scientific papers
Four-component quinazoline synthesis from simple anilines, aromatic aldehydes and ammonium iodide under metal-free conditions
Chen, Jinjin,Chang, Dan,Xiao, Fuhong,Deng, Guo-Jun
supporting information, p. 5459 - 5463 (2019/01/03)
A four-component procedure for the preparation of substituted quinazolines from anilines, aromatic aldehydes and ammonium iodide is described. The C-H bond ortho to the amino group in anilines was directly functionalized under metal-free conditions. Two a
Preparation of Quinazolines via a 2+2+2 Annulation from Aryldiazonium Salts and Nitriles
Ramanathan, Mani,Liu, Shiuh-Tzung
, p. 8290 - 8295 (2017/08/14)
A (2+2+2) modular synthesis of multisubstituted quinazolines has been realized by the direct reaction of aryldiazonium salts with two equivalent of nitriles. Reaction of aryldiazonium salt with a nitrile provides the initial formation of a reactive nitrilium ion, which is attacked by another molecule of nitrile followed by electrophilic cyclization to deliver the desired product. Notable flexibility in the substitution patterns, readily available substrates, short reaction time, transition metal-free, and gram-scale synthesis are the advantages of this method.
The reaction of tetralones with nitriles: A simple approach to the synthesis of new substituted benzo[h]quinazolines, benzo[f]quinazolines and dibenzo[a,i]phenanthridines
Herrera, Antonio,Martínez-Alvarez, Roberto,Chioua, Mourad,Chatt, Rachid,Chioua, Rachid,Sánchez, Angel,Almy, John
, p. 2799 - 2811 (2007/10/03)
The one-pot reaction of 1-tetralone with nitriles in the presence of triflic anhydride affords in good yields 2,4-disubstituted 5,6-dihydrobenzo[h] quinazolines, which oxidation with DDQ leads to the corresponding benzo[h]quinazolines. 2-Tetralone undergo
