60740-67-2

Usage

Class

Benzazepines

Explanation

Benzazepines are a class of organic compounds that consist of a benzene ring fused to an azepine ring. 1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine belongs to this class.

Explanation

A psychoactive drug is a substance that can alter the functioning of the central nervous system, leading to changes in mood, perception, or behavior. 1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine is a psychoactive drug.

Explanation

1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine has been used in the treatment of various psychological disorders, including depression and anxiety.

Explanation

As an SSRI, 1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine works by increasing the levels of serotonin, a neurotransmitter in the brain that regulates mood and emotional well-being.

Explanation

1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine is also known by the trade names Lu-34,380 and BDB.

Explanation

1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine has been studied for its potential use in treating substance abuse and addiction due to its psychoactive properties and effects on neurotransmitters.

Psychoactive drug

Yes

Treatment of psychological disorders

Depression and anxiety

Mechanism of action

Selective serotonin reuptake inhibitor (SSRI)

Potential use

Treating substance abuse and addiction

Upstream product

• 1150-91-0 1-benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepine 
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• 77853-46-4 4-(2-Methoxyphenyl)-butanenitrile 
• 135-02-4 ortho-anisaldehyde 
• 3193-62-2 N-benzyl-1-phenylethylamine 
• 24393-54-2 ethyl 3-(2-methoxyphenyl)prop-2-enoate 
• 70311-27-2 2-methoxybenzenepropanoic acid ethyl ester 
• 10493-37-5 3-(2-methoxyphenyl)propan-1-ol 
• 146253-19-2 3-(2-methoxyphenyl)propyl methanesulfonate 
• 123206-84-8 4-(2-bromophenyl)butyraldehyde 
• 15310-02-8 o-iodobenzanilide 
• 111457-18-2 N-(2-allyl-phenyl)-benzamide 
• 848172-03-2 1-benzoyl-2,5-dihydro-1H-1-benzazepine 
• 848172-02-1 N-allyl-N-(2-allylphenyl)benzamide 

Relevant academic research and scientific papers

Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite

A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution.

Conformation analyses, dynamic behavior and amide bond distortions of medium-sized heterocycles. 1. Partially and fully reduced 1-benzazepines

(Chemical Equation Presented) Five 1-benzazepine heterocycles were synthesized by utilizing transition-metal-catalyzed processes in key bond-forming steps. exo-Methylene and methyl substituents were introduced at position 5, as well as a unit of unsaturat

Synthesis of 2-substituted 1-benzyl-2,3,4,5-tetrahydro-1-benzazepines by palladium catalysis. Observation of a competitive β-hydride elimination pathway

A synthetic route to 1-benzyl-tetrahydro-1-benzazepine is reported, which also permits access to analogous structures with alkyl and aryl substituents at position-2 of the aliphatic ring. Palladium catalysis is utilized in two of the three steps, construc

Efficient nickel-mediated intramolecular amination of aryl chlorides

(Matrix presented) The use of an in situ generated Ni(0) catalyst associated with 2,2′-bipyridine or N,N′ -bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene (SIPr) as a ligand and NaO-t-Bu as the base for the intramolecular coupling of aryl chlorides with amines is described. The procedure has been applied to the formation of five-, six-, and seven-membered rings.

Intramolecular palladium-catalyzed aryl amination and aryl amidation

Upon treatment with a palladium catalyst and a suitable base, aromatic halides undergo intramolecular substitution to form five, six, and seven-membered rings. In a similar fashion aryl halides with pendant amides or sulfonamides are cyclized to form five and six-membered rings.

Eine einfache katalytische Methode zur Synthese von Arylaminen aus Arylbromid

Stichworte: Arylamine / Indoline / Palladiumverbindungen / Katalyse