60740-67-2

Basic information

• Product Name: 1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine
• CAS NO: 60740-67-2
• Molecular Formula: C₁₇H₁₉N
• Molecular Weight: 237.3395
• Mol File: 60740-67-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 393.1°C at 760 mmHg
• Flash Point: 171.5°C
• Density: 1.062g/cm³
• Vapor Pressure: 2.18E-06mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine(60740-67-2)
• EPA Substance Registry System: 1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine(60740-67-2)

Safety Data

• Hazardous Substances Data: 60740-67-2(Hazardous Substances Data)

Usage

Class

Benzazepines

Explanation

Benzazepines are a class of organic compounds that consist of a benzene ring fused to an azepine ring. 1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine belongs to this class.

Explanation

A psychoactive drug is a substance that can alter the functioning of the central nervous system, leading to changes in mood, perception, or behavior. 1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine is a psychoactive drug.

Explanation

1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine has been used in the treatment of various psychological disorders, including depression and anxiety.

Explanation

As an SSRI, 1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine works by increasing the levels of serotonin, a neurotransmitter in the brain that regulates mood and emotional well-being.

Explanation

1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine is also known by the trade names Lu-34,380 and BDB.

Explanation

1-benzyl-2,3,4,5-tetrahydro-1H-1-benzazepine has been studied for its potential use in treating substance abuse and addiction due to its psychoactive properties and effects on neurotransmitters.

Psychoactive drug

Yes

Treatment of psychological disorders

Depression and anxiety

Mechanism of action

Selective serotonin reuptake inhibitor (SSRI)

Potential use

Treating substance abuse and addiction

Upstream product

• 1150-91-0 1-benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 146253-19-2 3-(2-methoxyphenyl)propyl methanesulfonate 
• 10493-37-5 3-(2-methoxyphenyl)propan-1-ol 
• 70311-27-2 2-methoxybenzenepropanoic acid ethyl ester 
• 24393-54-2 ethyl 3-(2-methoxyphenyl)prop-2-enoate 
• 3193-62-2 N-benzyl-1-phenylethylamine 
• 135-02-4 ortho-anisaldehyde 
• 77853-46-4 4-(2-Methoxyphenyl)-butanenitrile 
• 123206-84-8 4-(2-bromophenyl)butyraldehyde 
• 583-55-1 1-Bromo-2-iodobenzene 
• 15310-02-8 o-iodobenzanilide 
• 111457-18-2 N-(2-allyl-phenyl)-benzamide 
• 848172-02-1 N-allyl-N-(2-allylphenyl)benzamide 
• 848172-03-2 1-benzoyl-2,5-dihydro-1H-1-benzazepine 

Relevant articles and documents

Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite

A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution.

Synthesis of 2-substituted 1-benzyl-2,3,4,5-tetrahydro-1-benzazepines by palladium catalysis. Observation of a competitive β-hydride elimination pathway

A synthetic route to 1-benzyl-tetrahydro-1-benzazepine is reported, which also permits access to analogous structures with alkyl and aryl substituents at position-2 of the aliphatic ring. Palladium catalysis is utilized in two of the three steps, construc

Intramolecular palladium-catalyzed aryl amination and aryl amidation

Upon treatment with a palladium catalyst and a suitable base, aromatic halides undergo intramolecular substitution to form five, six, and seven-membered rings. In a similar fashion aryl halides with pendant amides or sulfonamides are cyclized to form five and six-membered rings.