60756-87-8

Upstream product

• 108-30-5 succinic acid anhydride 
• 618-36-0 rac-methylbenzylamine 

Downstream Products

• 65084-17-5 5-hydroxy-1-(1-phenylethyl)pyrrolidin-2-one 
• 1285559-98-9 5-(1H-indol-3-yl)-1-(1-phenylethyl)pyrrolidin-2-one 
• 1285560-05-5 5-(2-methyl-1H-indol-3-yl)-1-(1-phenylethyl)pyrrolidin-2-one 
• 1285560-09-9 5-(2-p-tolyl-1H-indol-3-yl)-1-(1-phenylethyl)pyrrolidin-2-one 
• 86841-96-5 1-(1-phenylethyl)-2,5-pyrrolidinedione 

Relevant academic research and scientific papers

Regioselective synthesis of 1-alkyl-5-(indol-3-yl- and -2-yl)pyrrolidin-2- ones from available reagents

The reaction under mild conditions of 1-alkyl-5-hydroxypyrrolidin-2-ones with different indoles having a free 3 position leads exclusively to 1-alkyl-5-(indol-3-yl)pyrrolidin-2-ones but if position 3 is occupied to 1-alkyl-5-(indol-2-yl)pyrrolidin-2-ones.

Chemical process

A process for the preparation of a compound of the formulae (Ia) and/or (Ib): STR1 wherein R1 and R2 are independently substituted or unsubstituted hydrocarbon groups or are joined together so as to form a carbocyclic or heterocyclic ring, and R3 is a substituted or unsubstituted hydrocarbon group; which process comprises the ring-closing cyclization of a compound of the formula (II): STR2 wherein R1, R2 and R3 are as defined in relation to formulae (Ia) and (Ib).