86841-96-5

Upstream product

• 108-30-5 succinic acid anhydride 
• 618-36-0 rac-methylbenzylamine 
• 110-63-4 Butane-1,4-diol 
• 110-15-6 succinic acid 
• 60756-87-8 N-(1-phenylethyl)-succinamic acid 

Downstream Products

• 65084-17-5 5-hydroxy-1-(1-phenylethyl)pyrrolidin-2-one 
• 1285559-98-9 5-(1H-indol-3-yl)-1-(1-phenylethyl)pyrrolidin-2-one 
• 1285560-05-5 5-(2-methyl-1H-indol-3-yl)-1-(1-phenylethyl)pyrrolidin-2-one 
• 1285560-09-9 5-(2-p-tolyl-1H-indol-3-yl)-1-(1-phenylethyl)pyrrolidin-2-one 

Relevant academic research and scientific papers

Versatile and sustainable synthesis of cyclic imides from dicarboxylic acids and amines by Nb2O5 as a base-tolerant heterogeneous lewis acid catalyst

Catalytic condensation of dicarboxylics acid and amines without excess amount of activating reagents is the most atom-efficient but unprecedented synthetic method of cyclic imides. Here we present the first general catalytic method, proceeding selectively and efficiently in the presence of a commercial Nb2O5 as a reusable and base-tolerant heterogeneous Lewis acid catalyst. The method is effective for the direct synthesis of pharmaceutically or industrially important cyclic imides, such as phensuximide, N-hydroxyphthalimide (NHPI), and unsubstituted cyclic imides from dicarboxylic acid or anhydrides with amines, hydroxylamine, or ammonia.

PROCESS OF FORMING A CYCLIC IMIDE

A process is provided for the synthesis of a cyclic imide. A primary amine and a diol compound are contacted in the presence of a Ruthenium (II) complex. The Ruthenium (II) catalyst includes at least one of an alicyclic ligand, an aromatic ligand, an arylalicyclic ligand, an arylaliphatic ligand and a phosphine ligand.

Regioselective synthesis of 1-alkyl-5-(indol-3-yl- and -2-yl)pyrrolidin-2- ones from available reagents

The reaction under mild conditions of 1-alkyl-5-hydroxypyrrolidin-2-ones with different indoles having a free 3 position leads exclusively to 1-alkyl-5-(indol-3-yl)pyrrolidin-2-ones but if position 3 is occupied to 1-alkyl-5-(indol-2-yl)pyrrolidin-2-ones.

Synthesis of cyclic imides from simple diols

There's something imide so strong: Cyclic imides were synthesized from simple diols with primary amines in a single step using an in-situ-generated ruthenium catalytic system. The atom-economical and operatively simple syntheses of succinimides, phthalimides, and glutarimides, which are important building blocks in natural products and drugs, was also demonstrated. Copyright

A NOVEL METHOD FOR THE ONE-STEP SYNTHESIS OF N-ALKYL IMIDES BY THE USE OF 1,1'-DIMETHYLSTANNOCENE

Various N-alkyl imides are easely prepared in good yields under nearly neutral conditions from equimolar amounts of cyclic acid anhydrides and primary amines by the use of 1,1'-dimethylstannocene.