60768-66-3

Usage

Uses

Used in Pharmaceutical Industry:
1,2-Benzisothiazole,5-nitrois used as a key intermediate in the synthesis of various pharmaceuticals due to its unique chemical structure and bioactivity. Its antimicrobial and antifungal properties make it a valuable component in the development of new drugs targeting a range of infections.
Used in Agrochemical Industry:
In the agrochemical sector, 1,2-Benzisothiazole,5-nitrois employed as a building block for the creation of compounds with pesticidal properties. Its antimicrobial and antifungal characteristics contribute to the development of effective agricultural products aimed at protecting crops from diseases and pests.
Used in Dye Industry:
1,2-Benzisothiazole,5-nitrois utilized in the dye industry for the production of various dyes. Its chemical structure allows for the creation of dyes with specific color properties and stability, which are important for applications in textiles, plastics, and other materials.
Used in Corrosion Inhibition:
1,2-Benzisothiazole,5-nitrohas been studied for its potential use as a corrosion inhibitor. Its ability to form protective layers on metal surfaces can help prevent corrosion, making it a candidate for use in industrial applications where metal protection is crucial.
Used in Chemical Warfare Agents:
Although it is a sensitive topic, 1,2-Benzisothiazole,5-nitrohas been researched for its potential as an active ingredient in chemical warfare agents due to its toxic properties. However, it is imperative that such compounds are handled with extreme caution and under strict regulatory control to prevent misuse and ensure safety.

InChI:InChI=1/C7H4N2O2S/c10-9(11)6-1-2-7-5(3-6)4-8-12-7/h1-4H

Upstream product

• 6361-21-3 2-chloro-5-nitrobenzaldehyde 
• 27996-87-8 2-fluoro-5-nitrobenzaldehye 

Downstream Products

• 74631-35-9 2-Methylsulfanyl-5-nitro-benzonitrile 
• 74617-10-0 2-Chloro-6-octylsulfanyl-benzonitrile 
• 52673-94-6 3-amino-5-nitro-benzo[b]thiophene-2-carbonitrile 
• 74617-13-3 5-Nitro-2-(2-oxo-2-phenyl-ethylsulfanyl)-benzonitrile 
• 74617-12-2 5-Nitro-2-(2-oxo-propylsulfanyl)-benzonitrile 
• 74617-16-6 2-mercapto-5-nitrobenzonitrile 
• 75608-07-0 5-hydroxy-1,2-benzisothiazole 
• 53473-85-1 benzo[d]isothiazol-5-amine 
• 30747-87-6 3-chloro-5-nitro-1,2-benzisothiazole 
• 74617-41-7 3-Benzoylamino-5-nitro-thionaphthen-2-carbonsaeureamid 
• 74617-37-1 2-Phenyl-8-nitro-thionaphtheno<3,2-d>pyrimid-3H-on 
• 74617-35-9 2-Phenyl-9-chlor-thionaphtheno<3,2-d>pyrimid-4H-on 
• 52673-95-7 (3-amino-5-nitro-benzo[b]thiophen-2-yl)-phenyl-methanone 

Relevant academic research and scientific papers

Benzisothiazole compound and preparation method thereof

The invention discloses a benzisothiazole compound and a preparation method thereof. The preparation method of the benzisothiazole compound comprises the following step: in the presence of alkali and at a reaction temperature of 80-150 DEG C, carrying out a one-step reaction on an aromatic aldehyde compound, sulfur powder and inorganic ammonium salt to generate the benzisothiazole compound. The one-step synthesis of the benzisothiazole ring is realized under a relatively mild condition, the reaction is compatible with air and water, and the method has the advantages of simple steps, low cost, simplicity in operation and the like, and has very good application prospects.

HEMOGLOBIN MODIFIER COMPOUNDS AND USES THEREOF

Described herein are compounds, including pharmaceutically acceptable salts thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat, prevent or diagnose blood-based diseases, disorders or conditions.

9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS

The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula (I), wherein R1 is H or C1-5alkyl; X is O or NR2, wherein R2 is H, C1-5alkyl or C2-5acyl and Ar is C6-10aryl or a 5-10 membered heteroaryl ring system, both being optionally substituted with one to three of R3-R5 independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynyl, CN, NO2, hydroxy, phenyl, phenoxy and phenylC1-2alkoxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein said phenyl, phenoxy and phenylC1-2alkoxy are optionally substituted with one to three substituents independently selected from halogen and methyl or two of R3-R5 at adjacent positions together form a methylenedioxy or propylene unit, with the proviso that the compounds exo-9-methyl-3-phenoxy-9-azabicyclo[3.3.1]nonane and N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H indazole-5-amine are excluded, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.

9-Azabicyclo[3.3.1]nonane derivatives

The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.

PROCESS FOR THE PREPARATION OF 6-(PERFLUOROALKYL)URACIL COMPOUNDS FROM CARBAMATE COMPOUNDS

An improved process for the preparation of 6-(perfluoroalkyl)uracil compounds having structural formula (I) from carbamate compounds having structural formula (II).

Processes and intermediate compounds for the preparation of 2-(N,N-disubstituted) amino-4-(perfluoroalkyl)-1, 3- oxazin-6-one and 6-(perfluoroalkyl) uracil compounds

An improved process and intermediate compounds for the preparation of 2-(N,N-disubstituted)amino-4-(perfluoroalkyl)-1,3-oxazin-6-one compounds having the structural formula I and an improved process for the preparation of 6-(perfluoroalkyl)uracil compound

Process for the preparation of 6-(perfluoroalkyl) uracil compounds form urea compounds

An improved process for the preparation of 6-(perfluoroalkyl)uracil compounds having the structural formula I from urea compounds having the structural formula II

3-(1,2-benzisothiazol- and isoxazol-5-Y1)-2,4(1H,3H)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-y1)-4(3H)-pyrimidinone or thione herbicidal agents

There are provided 3-(1,2-benzisothiazol- and isoxazol-5-yl)-2,4(1H,3H)-pyrimidinedione or thione compounds of formula I and 3-(1,2-benzisothiazol- and isoxazol-5-yl)-4(3H)-pyrimidinone or thione compounds of formula II Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.

New Synthesis with Elemental Sulfur. - Preparation of 1,2-Benzisothiazoles and Some Secondary Reactions

The preparation of new 1,2-benzisothiazoles 2,3,5 and of thienoisothiazole 4 is described.The thioethers 8 have been obtained from 2 and 3 by ring opening with alcoholate and reaction with halomethyl compounds.On cyclisation, the thioethers 8 give the thionaphthenes 11.The ring systems of thionaphthenopyrimidines 10 and 12 have been prepared from 11.