75608-07-0Relevant academic research and scientific papers
HEMOGLOBIN MODIFIER COMPOUNDS AND USES THEREOF
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Paragraph 00426, (2018/02/28)
Described herein are compounds, including pharmaceutically acceptable salts thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat, prevent or diagnose blood-based diseases, disorders or conditions.
9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS
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Page/Page column 17, (2010/11/26)
The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula (I), wherein R1 is H or C1-5alkyl; X is O or NR2, wherein R2 is H, C1-5alkyl or C2-5acyl and Ar is C6-10aryl or a 5-10 membered heteroaryl ring system, both being optionally substituted with one to three of R3-R5 independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynyl, CN, NO2, hydroxy, phenyl, phenoxy and phenylC1-2alkoxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein said phenyl, phenoxy and phenylC1-2alkoxy are optionally substituted with one to three substituents independently selected from halogen and methyl or two of R3-R5 at adjacent positions together form a methylenedioxy or propylene unit, with the proviso that the compounds exo-9-methyl-3-phenoxy-9-azabicyclo[3.3.1]nonane and N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H indazole-5-amine are excluded, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.
9-Azabicyclo[3.3.1]nonane derivatives
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Page/Page column 9/2, (2010/11/27)
The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.
Condensed Isothiazoles. Part 7. Substitution Reactions of 3-Methyl-1,2-benzisothiazole and Some of Its 4- and 5-Substituted Derivatives
Clarke, Kenneth,Gleadhill, Brian,Scrowston, Richard M.
, p. 2845 - 2866 (2007/10/02)
Some electrophilic substitution reactions of 3-methyl-1,2-benzisothiazole and its 4-bromo-, 5-acetamido-, 5-amino, 5-bromo-, 5-hydroxy-, and 5-methoxy-derivatives are described. 4-Chloro, 4-bromo-, 4,6-dibromo- and 4-nitro-3-methyl-1,2-benzisothiazole may be obtained by deamination of the appropriate substitution products of 5-amino-3-methyl-1,2-benzisothiazole.Improved syntheses of 7-chloro- and 7-bromo-3-methyl-1,2-benzisothiazole have been achieved.
