60775-11-3

Usage

Appearance

Yellow crystalline powder

Usage

a. Reagent in organic synthesis
b. Precursor to dyes and pigments
c. Production of pharmaceuticals
d. Chemical intermediate in synthesis of other organic compounds

Solubility

a. Insoluble in water
b. Soluble in organic solvents

Odor

Strong

Environmental and human health hazards

Potential hazards, should be handled with caution in a controlled laboratory setting

Upstream product

• 150-60-7 dibenzyl disulphide 
• 60-29-7 diethyl ether 
• 528-76-7 2,4-dinitrobenzenesulfenyl chloride 
• 64-19-7 acetic acid 
• 100-53-8 phenylmethanethiol 
• 70-34-8 2,4-Dinitrofluorobenzene 
• 61775-34-6 SS-benzyl O-methyl carbono(dithioperoxoate) 

Downstream Products

• 57413-30-6 N-(2-Benzyldisulfanyl-ethyl)-acetamide 
• 57413-29-3 benzyl isopropyl disulfide 
• 21230-19-3 Ethoxycarbonylmethyl-benzyl-disulfid 
• 528-76-7 2,4-dinitrobenzenesulfenyl chloride 

Relevant academic research and scientific papers

Esterase-Activated Perthiocarbonate Persulfide Donors Provide Insights into Persulfide Persistence and Stability

Persulfides (RSSH) are important reactive sulfur species (RSS) that are intertwined with the biological functions of hydrogen sulfide (H2S). The direct study of persulfides is difficult, however, due to their both nucleophilic and electrophilic

A Vinyl-Boronate Ester-Based Persulfide Donor Controllable by Hydrogen Peroxide, a Reactive Oxygen Species (ROS)

A vinyl boronate ester-based persulfidating agent that is selectively activated by hydrogen peroxide, which is a reactive oxygen species (ROS), and efficiently generated a persulfide by a hitherto unexplored 1,4-O,S-relay mechanism is reported. This donor was found to protect cells from cytotoxicity induced by oxidants, and the major byproduct is cinnamaldehyde, which is widely used in the food industry as an additive.

An Esterase-Sensitive Prodrug Approach for Controllable Delivery of Persulfide Species

A strategy to deliver a well-defined persulfide species in a biological medium is described. Under near physiological conditions, the persulfide prodrug can be activated by an esterase to generate a “hydroxymethyl persulfide” intermediate, which rapidly collapses to form a defined persulfide. Such persulfide prodrugs can be used either as chemical tools to study persulfide chemistry and biology or for future development as H2S-based therapeutic reagents. Using the persulfide prodrugs developed in this study, the reactivity between S-methyl methanethiosulfonate (MMTS) with persulfide was unambiguously demonstrated. Furthermore, a representative prodrug exhibited potent cardioprotective effects in a murine model of myocardial ischemia-reperfusion (MI/R) injury with a bell shape therapeutic profile.