60786-69-8Relevant academic research and scientific papers
Selective C-H chalcogenation of thiazoles: Via thiazol-2-yl-phosphonium salts
Zi, You,Wagner, Konrad,Sch?mberg, Fritz,Vilotijevic, Ivan
, p. 5183 - 5191 (2020/07/23)
Thiazoles and benzothiazoles undergo regioselective C2-H chalcogenation via the sequence of thiazole C2-functionalization with phosphines to produce phosphonium salts which in turn react with S- and Se-centered nucleophiles to give products of C2-H chalco
Rhodium-catalyzed synthesis of unsymmetric di(heteroaryl) compounds via heteroaryl exchange reactions
Arisawa, Mieko
, p. 643 - 648 (2019/04/30)
Unsymmetric di(heteroaryl) HetAr–X–HetAr′ compounds have flexible and rigid groups, and are expected to exhibit various biological activities by interacting with proteins and nucleic acids. Then, synthesis of such compounds is critical for the development of drugs. Unsymmetric HetAr-X-HetAr′ compounds were efficiently synthesized by rhodium-catalyzed heteroaryl exchange reactions, which involved equilibrium control by judicious design of organic heteroaryl reagents. This method allows synthesis of unsymmetric HetAr–O–HetAr′, HetAr–S–HetAr′, and HetAr–CH2–HetAr′ compounds as well as HetAr–F compounds from heteroaryl aryl ethers and heteroaryl reagents. The rhodium-catalyzed heteroaryl exchange reaction was also applied to the synthesis of C–N-linked di(heteroaryl) compounds from N-benzoyl heteroarenes and heteroaryl aryl ethers. The synthesis has a broad applicability, which gives a diversity of novel unsymmetric HetAr–X–HetAr′ and C–N-linked di(heteroaryl)s compounds containing five- and six-membered heteroarenes.
Palladium Nanoparticles Immobilized on Nanosilica Triazine Dendritic Polymer (Pd np -nSTDP) as Catalyst in the Synthesis of Mono-, Di-, and Trisulfides through C-S Cross-Coupling Reactions
Isfahani, Amir Landarani,Mohammadpoor-Baltork, Iraj,Mirkhani, Valiollah,Moghadam, Majid,Khosropour, Ahmad Reza,Tangestaninejad, Shahram,Nasr-Esfahani, Mahboobeh,Rudbari, Hadi Amiri
supporting information, p. 645 - 652 (2014/04/03)
A wide variety of diaryl sulfides has been synthesized in excellent yields via C-S cross-couplings of aryl/heteroaryl halides with aromatic/heteroaromatic thiols in the presence of palladium nanoparticles immobilized on nanosilica triazine dendritic polymer (Pd np -nSTDP) as a reusable catalyst under thermal conditions and microwave irradiation. Pd np -nSTDP also showed excellent catalytic activity for the preparation of a series of di- and trisulfides with benzene, pyridine, pyrimidine, and/or 1,3,5-triazine as the central cores by one-pot multi C-S cross-coupling reactions. Georg Thieme Verlag Stuttgart. New York.
Lewis acid-catalyzed, copper(II)-mediated synthesis of heteroaryl thioethers under base-free conditions
Dai, Chao,Xu, Zhaoqing,Huang, Fei,Yu, Zhengkun,Gao, Yan-Feng
experimental part, p. 4414 - 4419 (2012/06/18)
A Lewis acid (AgI, NiII, or FeII) catalyzed, CuII-mediated thiolation reaction between heteroarenes and thiols was achieved with good yield under base-free conditions. DMSO could serve as an effective methylthiolation reagent for the synthesis of heterocyclic methyl thioethers.
Reactions (SRN1) de nucleophiles soufres avec des halogenopyridines trifluoromethylees I. Synthese de sulfures dissymetriques heterocycliques
Chbani, Mohamed,Bouillon, Jean-Philippe,Chastanet, Jacqueline,Soufiaoui, Mohamed,Beugelmans, Rene
, p. 1053 - 1060 (2007/10/02)
Synthesis of unsymmetrical heterocyclic sulfides via SRN1 reactions.While 2-chloropyridine reacts poorly with deactivated sulfanions derived from heterocyclic thiols (HS-Het), 2-chloropyridines carrying a trifluoromethyl electron-withdrawing group react efficiently (position 3 or 5), moderately (position 6) or poorly (position 4) yielding unsymmetrical sulfides (CF3)-Pyr-S-Het. - Keywords: trifluoromethylated 2-chloropyridine / heterocyclic thiol / unsymmetrical sulfide
ORTHO-LITHIATION OF 2-(BENZOTHIAZOL-2-YLTHIO)PYRIDINE. PREPARATION OF 2,3-DISUBSTITUTED PYRIDINES
Katritzky, Alan R.,Aurrecoechea, Jose M.,Miguel, Luis M. Vazquez de
, p. 427 - 436 (2007/10/02)
2-(Benzothiazol-2-ylthio)pyridine undergoes lithiation exclusively at the 3-position.The products of reaction with electrophiles of the lithiated species undergo sulfide cleavage to give 3-substituted 2-alkylthiopyridines and/or 3-substituted pyridine-2-thiones.
