60814-30-4

Basic information

• Product Name: 4-ACETYLQUINOLINE
• Synonyms: 4-ACETYLQUINOLINE;1-(quinolin-4-yl)ethanone
• CAS NO: 60814-30-4
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.19526
• Mol File: 60814-30-4.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 312.055°C at 760 mmHg
• Flash Point: 150.497°C
• Appearance: /
• Density: 1.154g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-ACETYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETYLQUINOLINE(60814-30-4)
• EPA Substance Registry System: 4-ACETYLQUINOLINE(60814-30-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 60814-30-4(Hazardous Substances Data)

Usage

General Description

4-Acetylquinoline is a chemical compound with the molecular formula C11H9NO. It is a yellow solid that is used in the production of synthetic dyes, pharmaceuticals, and other organic compounds. 4-Acetylquinoline is also used as a building block in the synthesis of various heterocyclic compounds and has been studied for its potential biological and pharmacological activities. It is a versatile compound with a wide range of applications in the chemical and pharmaceutical industries.

InChI:InChI=1/C11H9NO/c1-8(13)9-6-7-12-11-5-3-2-4-10(9)11/h2-7H,1H3

Upstream product

• 91-22-5 quinoline 
• 127-17-3 2-oxo-propionic acid 
• 55908-34-4 1-Quinolin-4-yl-ethanol 
• 62484-52-0 4-ethynylquinoline 
• 79476-06-5 4-trimethylstannyl-quinoline 
• 75-36-5 acetyl chloride 
• 611-35-8 4-chloroquinoline 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 111-34-2 -butyl vinyl ether 
• 208934-37-6 quinolin-4-yl trifluoromethanesulfonate 
• 75-16-1 methylmagnesium bromide 
• 486-74-8 4-quinolinic acid 
• 91-56-5 indole-2,3-dione 
• 19020-26-9 4-ethylquinoline 

Downstream Products

• 1187669-66-4 N-(3-methylphenyl)-4-(4-quinolinyl)-1,3-thiazol-2-amine 

Relevant articles and documents

Synthesis and biological evaluation of novel 4-(6-substituted quinolin-4-yl)-N-aryl thiazol-2-amine derivatives as potential antimicrobial agents

Cyclocondensation reaction of 4-(2-bromoacetyl)quinolin-1-ium bromide (4a–d) with substituted arylthiourea, (5a–g) afforded 4-(6-substituted quinolin-4-yl)-N-aryl/pyridyl thiazol-2-amine (6a-ab). These newly synthesized derivatives were evaluated for in vitro antibacterial activity against Escherichia coli (NCIM 2574), Proteus mirabilis (NCIM 2388) (Gram-negative strains), Bacillus subtilis (NCIM 2063), Staphylococcus albus (NCIM 2178) (Gram-positive strains) and in vitro antifungal activity against Aspergillus niger (ATCC 504) and Candida albicans (NCIM 3100). Compounds 6a, 6b, 6d, 6f, 6k, and 6l showed moderate to good antibacterial activity against S. albus. Ten derivatives 6c, 6q, 6r, 6s, 6t, 6v, 6w, 6x, 6y, and 6aa, showed moderate to good activity against A. niger. N-[4-(Quinolin-4-yl)-1,3-thiazol-2-yl]pyridin-2-amine presented comparable activity against A. niger with respect to standard drug Rouconazole.

Transition-Metal-Free Oxidation of Benzylic C-H Bonds of Six-Membered N-Heteroaromatic Compounds

A novel oxidation of benzylic C-H bonds for the synthesis of diverse six-membered N-heteroaromatic aldehydes and ketones has been developed. The obvious advantages of this approach are the simple operation, mild reaction conditions, and without use of toxic reagent and transition metal. The present method should provide a useful access for the synthesis and modification of N-heterocycles.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.