60890-29-1

Basic information

• Product Name: (3,4-dimethoxybenzoyl)acetic acid
• Synonyms: (3,4-dimethoxybenzoyl)acetic acid
• CAS NO: 60890-29-1
• Molecular Weight: 224.213
• Mol File: 60890-29-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 160.1-161.3 °C
• Boiling Point: 422.6±35.0 °C(Predicted)
• Density: 1.244±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (3,4-dimethoxybenzoyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-dimethoxybenzoyl)acetic acid(60890-29-1)
• EPA Substance Registry System: (3,4-dimethoxybenzoyl)acetic acid(60890-29-1)

Safety Data

• Hazardous Substances Data: 60890-29-1(Hazardous Substances Data)

Usage

General Description

(3,4-dimethoxybenzoyl)acetic acid is a chemical compound with the molecular formula C11H12O5. It is a derivative of acetic acid and contains a benzoyl group as well as two methoxy groups. (3,4-dimethoxybenzoyl)acetic acid is mainly used in organic synthesis as a reagent for the synthesis of various organic compounds. It is also utilized in the pharmaceutical industry for the production of certain drugs. Additionally, (3,4-dimethoxybenzoyl)acetic acid has potential applications in the field of materials science and is being studied for its properties as a photoresist material for microelectronics. Overall, this chemical has a variety of uses in different industries due to its unique structure and properties.

Upstream product

• 18457-04-0 bis(trimethylsilyl) malonate 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 74053-93-3 methyl 3-(3,4-dimethoxyphenyl)-3-oxopropionate 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 93-07-2 Veratric acid 
• 76787-81-0 3-oxo-2-veratroyl-butyric acid ethyl ester 
• 4687-37-0 ethyl 3,4-dimethoxybenzoylacetate 

Downstream Products

• 60890-27-9 1-(3,4-dimethoxyphenyl)-2-(pyrrolidin-2-yl)ethan-1-one 
• 23837-54-9 1-(3,4-dimethoxyphenyl)-2-(piperidin-2-yl)ethan-1-one 
• 1644085-83-5 1-(3,4-dimethoxyphenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one 
• 67257-60-7 (+/-)-N-Acetyl-ruspolinon 
• 26503-67-3 (+/-)-6,7-di(3,4-dimethoxyphenyl)-1,2,3,5,8,8a-hexahydro-indolizine 
• 76787-76-3 6,7-Di(3',4'-dimethoxyphenyl)-5-oxo-1,2,3,5,8,8a-hexahydro-indolizine 
• 76787-77-4 1-(3,4-Dimethoxyphenyl)-2-<1-<(3,4-dimethoxyphenyl)acetyl>pyrrolidin-2-yl>ethanone 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 

Relevant articles and documents

Enantioselective decarboxylative Mannich reaction of β-keto acids withC-alkynylN-BocN,O-acetals: access to chiral β-keto propargylamines

The chiral keto-substituted propargylamines are an essential class of multifunctional compounds in the field of organic and pharmaceutical synthesis and have attracted considerable attention, but the related synthetic approaches remain limited. Therefore, a concise and efficient method for the enantioselective synthesis of β-keto propargylaminesviachiral phosphoric acid-catalyzed asymmetric Mannich reaction between β-keto acids andC-alkynylN-BocN,O-acetals as easily availableC-alkynyl imine precursors has been demonstrated here, affording a broad scope of β-ketoN-Boc-propargylamines in high yields (up to 97%) with generally high enantioselectivities (up to 97?:?3 er).

Synthesis of the Alkaloids, 3',4'-Dimethoxy-2-82-piperidyl)acetophenone, Julandine, and Cryptopleurine

Condensation of (3,4-dimethoxybenzoyl)acetic acid (2) with enzyme-generated 3,4,5,6-tetrahydropyridine (3) gives 3',4'-dimethoxy-2-(2-piperidyl)acetophenone (4) which, by reaction with p-methoxyphenylacetaldehyde followed by titanium(IV) chloride- or silicon(IV) chloride-catalysed cyclisation of the resulting enamine (6), leads to julandine (7); thallium(III) trifluoroacetate oxidation of (7) gives cryptopleurine (8) and, as a very minor product, the isomer (9).

A New Synthesis of Septicine, a Secophenanthroindolizine Alkaloid

Septicine , an alkaloid isolated from Ficus septica and Tylophora asthmatica, has been synthesized using 2-(3',4'-dimethoxyphenacyl)pyrrolidine (6) and 3,4-dimethoxy-phenylacetyl chloride (11) as the essential intermediates.Condensation of 6 and 11 affords 2-(3',4'-dimethoxyphenacyl)-N-(3'',4''-dimethoxyphenylacetyl)pyrrolidine (12) which on treatment with potassium-t-butoxide furnishes 6,7-di-(3',4'-dimethoxyphenyl)-5-oxo-1,2,3,5,8,8a-hexahydroindolizine (13).LAH reduction of 13 affords septicine (1), identical (co-TLC, IR, PMR, m.m.p.) with a natural sample.