60890-27-9Relevant articles and documents
Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction
Galman, James L.,Slabu, Iustina,Parmeggiani, Fabio,Turner, Nicholas J.
supporting information, p. 11316 - 11319 (2018/10/24)
Heterocycles based on piperidine and pyrrolidine are key moieties in natural products and pharmaceutically active molecules. A novel multi-enzymatic approach based on the combination of a lipase with an α,ω-diamine transaminase is reported, opening up the synthesis, isolation and characterisation of a broad range of 2-substituted N-heterocycle alkaloids.
Total synthesis of the tylophora alkaloids rusplinone, 13aα- secoantofine, and antofine using a multicatalytic oxidative aminochlorocarbonylation/Friedel-Crafts reaction
Ambrosini, Lisa M.,Cernak, Tim A.,Lambert, Tristan H.
experimental part, p. 4882 - 4887 (2010/08/06)
A rapid synthetic approach to the tylophora alkaloids antofine and 13aα-secoantofine is presented that makes use of a multicatalytic oxidative aminochlorocarbonylation/Friedel-Crafts reaction as the key step. This reaction, along with a one-pot, three-ste
Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents
Sharma, Vedula M.,Adi Seshu,Vamsee Krishna,Prasanna,Chandra Sekhar,Venkateswarlu,Rajagopal, Sriram,Ajaykumar,Deevi, Dhanvanthri S.,Rao Mamidi,Rajagopalan
, p. 1679 - 1682 (2007/10/03)
A series of 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues were synthesized and evaluated for cytotoxic activity against eight human cancer cell lines. Compounds 18, 21, 28, 29, 30 and 31 showed cytotoxic activity with GI50 value