76787-77-4

Basic information

• Product Name: Pyrrolidine, 1-[(3,4-dimethoxyphenyl)acetyl]-2-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]-
• CAS NO: 76787-77-4
• Molecular Formula: C24H29NO6
• Molecular Weight: 427.497
• Mol File: 76787-77-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 1-[(3,4-dimethoxyphenyl)acetyl]-2-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-[(3,4-dimethoxyphenyl)acetyl]-2-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]-(76787-77-4)
• EPA Substance Registry System: Pyrrolidine, 1-[(3,4-dimethoxyphenyl)acetyl]-2-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]-(76787-77-4)

Safety Data

• Hazardous Substances Data: 76787-77-4(Hazardous Substances Data)

Upstream product

• 60890-27-9 1-(3,4-dimethoxyphenyl)-2-(pyrrolidin-2-yl)ethan-1-one 
• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 
• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 4687-37-0 ethyl 3,4-dimethoxybenzoylacetate 
• 76787-81-0 3-oxo-2-veratroyl-butyric acid ethyl ester 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 86980-84-9 2-(3,4-Dimethoxyphenyl)-2,3,3a,4,5,6-hexahydropyrrolo<1,2-b>isoxazole 
• 6380-23-0 3,4-dimethoxystyrene 
• 74053-93-3 methyl 3-(3,4-dimethoxyphenyl)-3-oxopropionate 
• 60890-29-1 (3,4-dimethoxybenzoyl)acetic acid 

Downstream Products

• 26503-67-3 (+/-)-6,7-di(3,4-dimethoxyphenyl)-1,2,3,5,8,8a-hexahydro-indolizine 

Relevant articles and documents

Synthesis of (±)-septicine and (±)-tylophorine by regioselective [3 + 2] cycloaddition

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Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents

A series of 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues were synthesized and evaluated for cytotoxic activity against eight human cancer cell lines. Compounds 18, 21, 28, 29, 30 and 31 showed cytotoxic activity with GI50 value

A New Synthesis of Septicine, a Secophenanthroindolizine Alkaloid

Septicine , an alkaloid isolated from Ficus septica and Tylophora asthmatica, has been synthesized using 2-(3',4'-dimethoxyphenacyl)pyrrolidine (6) and 3,4-dimethoxy-phenylacetyl chloride (11) as the essential intermediates.Condensation of 6 and 11 affords 2-(3',4'-dimethoxyphenacyl)-N-(3'',4''-dimethoxyphenylacetyl)pyrrolidine (12) which on treatment with potassium-t-butoxide furnishes 6,7-di-(3',4'-dimethoxyphenyl)-5-oxo-1,2,3,5,8,8a-hexahydroindolizine (13).LAH reduction of 13 affords septicine (1), identical (co-TLC, IR, PMR, m.m.p.) with a natural sample.