60906-77-6

Usage

Furan derivative

A modified furan ring
2-(4-methylbenzyl)furan is derived from the furan ring, which is a five-membered heterocyclic compound containing one oxygen atom.

Benzyl group attachment

Attached to the second carbon atom
A benzyl group (a phenyl ring attached to a methyl group) is connected to the second carbon atom of the furan ring in 2-(4-METHYLBENZYL)FURAN.

Sweet, floral aroma

Commonly used in fragrances and flavors
The compound has a pleasant, sweet, and floral scent, making it a popular choice for use in perfumes, scents, and food flavorings.

Intermediate in synthesis

Pharmaceutical and agrochemical production
2-(4-methylbenzyl)furan serves as an intermediate compound in the synthesis of various pharmaceuticals and agrochemicals, aiding in the creation of these products.

Potential applications in organic electronics and materials science

Unique chemical structure and properties
The compound's distinct chemical structure and properties make it a promising candidate for use in the development of organic electronics and materials science applications.

Industrial and research applications

Aromatic and versatile nature
Due to its aromatic and versatile nature, 2-(4-methylbenzyl)furan is widely used in various industrial and research settings.

InChI:InChI=1/C12H12O/c1-10-4-6-11(7-5-10)9-12-3-2-8-13-12/h2-8H,9H2,1H3

Upstream product

• 98-01-1 furfural 
• 106-38-7 para-bromotoluene 
• 118486-94-5 2-(tributylstannyl)furan 
• 104-82-5 4-Methylbenzyl chloride 
• 13331-23-2 fur-2-ylboronic acid 
• 55552-70-0 furan-3-boronic acid 
• 624-31-7 4-tolyl iodide 
• 110-00-9 furan 
• 98-00-0 (2-furyl)methyl alcohol 
• 31614-66-1 tributyl(p-tolyl)stannane 
• 5720-05-8 4-methylphenylboronic acid 
• 4664-45-3 5-(4-methyl-benzyl)-furan-2-carboxylic acid 
• 108-88-3 toluene 
• 61834-23-9 methyl 5-(4-methylbenzyl)furan-2-carboxylate 

Downstream Products

• 80733-54-6 5-[(4-methylphenyl)methyl]furan-2-carbaldehyde 
• 60906-04-9 3-(4-methyl-benzyl)-pyridazine 

Relevant academic research and scientific papers

Synthetic method of diarylmethanes

The invention discloses a synthetic method of diarylmethanes. The method is characterized in that benzyl pseudohalide and aromatic boric acid are reacted in an organic solvent under alkaline condition. The method employs easily available raw materials, conversion is realized under effect of no transition metal catalysis, water-free and oxygen-free are not required, Lewis acid catalysis is not required, the method has wide substrate universality, and various substituted diarylmethanes can be synthesized by the method.

Intra- and Intermolecular Nickel-Catalyzed Reductive Cross-Electrophile Coupling Reactions of Benzylic Esters with Aryl Halides

Nickel-catalyzed cross-electrophile coupling reactions of benzylic esters and aryl halides have been developed. Both inter- and intramolecular variants proceed under mild reaction conditions. A range of heterocycles and functional groups are tolerated under the reaction conditions. Additionally, the first example of a stereospecific cross-electrophile coupling of a secondary benzylic ester is described. Crossed off: Nickel-catalyzed cross-electrophile coupling reactions of benzylic esters and aryl halides have been developed. Both inter- and intramolecular variants proceed under mild reaction conditions, and a range of heterocycles and functional groups are tolerated. Additionally, the first example of a stereospecific cross-electrophile coupling of a secondary benzylic ester is described.

Coupling of arylboronic acids with benzyl halides or mesylates without adding transition metal catalysts

We report herein a transition-metal-free coupling reaction of arylboronic acids with benzyl halides and mesylates for the construction of C(sp2)[sbnd]C(sp3) bonds. A unique feature of this coupling reaction is the formation regioisomers in some cases. Mechanistic studies suggest that this reaction may proceed via an unprecedented Friedel–Crafts-type reaction pathway under base conditions with the assistance of boronic acid moiety.

AsCat and FurCat: New Pd catalysts for selective roomerature Stille cross-couplings of benzyl chlorides with organostannanes

Two novel succinimide-based palladium complexes, AsCat and FurCat, are highly efficient catalysts for roomerature Stille cross-coupling of organostannanes with benzyl chlorides. The air- and moisture-stable catalysts are prepared in one step, and the coupling reactions proceed with a high selectivity for the benzyl position under mild conditions without the need for additives. This journal is

Organocatalytic Nonclassical Trienamine Activation in the Remote Alkylation of Furan Derivatives

A new approach for the stereoselective remote alkylation of furan derivatives is reported. The reaction of 5-alkylfurfurals with nitroolefins as electrophilic counterparts occurs at their exocyclic ε-position and proceeds through the intermediacy of a non

Efficient Pd-catalyzed heterobenzylic cross-coupling using sulfonium salts as substrates and (PhO)3P as a supporting ligand

S-(2-Furanylmethyl)tetramethylenesulfonium hexafluorophosphate, S-(2-thienylmethyl)tetramethylenesulfonium hexafluorophosphate, S-(3-thienylmethyl)tetramethylenesulfonium hexafluorophosphate, and S-(N-tert-butoxycarbonyl-2-pyrrolylmethyl)tetramethylenesulfonium hexafluorophosphate have been conveniently prepared from the corresponding alcohols. These stable heterobenzylic sulfonium salts participate in palladium-catalyzed Stille cross-couplings with organostannanes. All but the last mentioned sulfonium salt are also active participants in palladium-catalyzed cross-coupling reactions with boronic acids and organozinc halides. Because the heterobenzylic cross-coupling reactants are potent alkylating agents, they scavenge the typical phosphines and arsines that otherwise could be used to stabilize the palladium catalyst over extended reaction times. This problem was overcome by the use of (PhO)3P as a unique supporting ligand for the palladium-catalyzed cross-coupling of heterobenzylic sulfonium salts.

BASE CLEAVAGE OF SUBSTITUTED - AND -TRIMETHYLSILANE. STABILIZATION OF CARBANIONIC CENTRES BY 2-THIENYL AND 2-FURYL GROUPS

Rates of cleavage by NaOMe-MeOH at 25 deg C have been determined for (2-thienyl)2CHSiMe3 and for the compounds Ph(2-thienyl)CHSiMe3 and Ph(2-furyl)CHSiMe3 and some of their derivatives with a substituent in the m- or p-position of the phenyl group or the