60912-61-0Relevant academic research and scientific papers
Conformational and Chiral Properties of Cyclic-tri(N-methyl-meta-benzamide) Bearing Amidino Groups
Nishiyama, Shizuka,Urushibara, Ko,Masu, Hyuma,Azumaya, Isao,Kagechika, Hiroyuki,Tanatani, Aya
, p. 487 - 491 (2015)
Cyclic triamides 4 bearing amidino groups at the meta position of the phenyl rings were synthesized, and their conformational properties in the crystal and in solution were examined. Compound 4a exists as a capsule-type dimer of the enantiomers with a bowl-shaped syn conformation in the crystal state. Compound 4 exists mainly in the syn form in solution, and chiral induction was observed upon addition of a chiral acid to a solution of 4a. Chirality 27:487-491, 2015.
Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur
Trifonov, Lena,Chumin, Katerina,Gvirtz, Raanan,Afri, Michal,Korshin, Edward E.,Cohen, Guy,Gruzman, Arie
, p. 709 - 711 (2021/01/12)
Novel polyfunctional arenesulfonamides as potential fungicides were prepared in eight steps from 3-amino-5-bromobenzoic acid. Among them, methyl 3-bromo-2-nitro-5-(N-phenylsulfamoyl)benzoate exhibiting significant cytotoxic activity against Malassezia fur
Cyclic-tri(N-methyl-meta-benzamide)s: Substituent effects on the bowl-shaped conformation in the crystal and solution states
Kakuta, Hiroki,Azumaya, Isao,Masu, Hyuma,Matsumura, Mio,Yamaguchi, Kentaro,Kagechika, Hiroyuki,Tanatani, Aya
experimental part, p. 8254 - 8260 (2010/11/02)
Cyclic trimers of 3-(N-alkylamino)benzoic acid (calix[3]amides) with various substituents at the meta position of the phenyl rings were synthesized and the effects of the substituents on the crystal structures and energy profiles in solution were examined. The calixamides existed in a syn conformation in the crystal state, and this was also the major conformation in solution, especially in polar solvents. The energy barrier between syn and anti conformers in the solution was not significantly affected by substituents (12.7-14.0 kcal/mol). The effect of the substituent on the temperature dependence of the syn/anti ratio are discussed.
Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors
Inglis, Steven R.,Zervosen, Astrid,Woon, Esther C. Y.,Gerards, Thomas,Teller, Nathalie,Fischer, Delphine S.,Luxen, André,Schofield, Christopher J.
supporting information; experimental part, p. 6097 - 6106 (2010/03/24)
Penicillin binding proteins (PBPs) catalyze steps in the biosynthesis of bacterial cell walls and are the targets for the β-lactam antibiotics. Non-β-lactam based antibiotics that target PBPs are of interest because bacteria have evolved resistance to the
