706791-83-5

Basic information

• Product Name: 3-AMINO-5-BROMOBENZOATE
• Synonyms: 3-AMINO-5-BROMOBENZOATE;Methyl 3-Amino-5-bromobenzoate
• CAS NO: 706791-83-5
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.07
• Mol File: 706791-83-5.mol
• Article Data: 29

Chemical Properties

• Melting Point: 83-88℃
• Boiling Point: 332.308 °C at 760 mmHg
• Flash Point: 154.775 °C
• Appearance: /
• Density: 1.578 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.38±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-5-BROMOBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-5-BROMOBENZOATE(706791-83-5)
• EPA Substance Registry System: 3-AMINO-5-BROMOBENZOATE(706791-83-5)

Safety Data

• Hazardous Substances Data: 706791-83-5(Hazardous Substances Data)

Usage

General Description

3-AMINO-5-BROMOBENZOATE is a chemical compound with the molecular formula C7H6BrNO2. It is a derivative of benzoic acid and contains an amino group and a bromo group attached to the benzene ring. 3-AMINO-5-BROMOBENZOATE is commonly used as an intermediate in organic synthesis for the production of various pharmaceuticals and agrochemicals. It is also known for its antimicrobial and antifungal properties, making it a valuable component in the development of new drugs and treatments. 3-AMINO-5-BROMOBENZOATE is a white to off-white solid that is soluble in organic solvents and is stable under normal conditions.

Upstream product

• 6307-87-5 methyl 3-bromo-5-nitrobenzoate 
• 618-95-1 methyl 3-nitrobenzoate 
• 121-92-6 3-nitrobenzoic acid 
• 6307-83-1 3-bromo-5-nitro-benzoic acid 
• 67-56-1 methanol 
• 42237-85-4 3-amino-5-bromobenzoic acid 

Downstream Products

• 1188322-84-0 methyl 3-bromo-5-(thiophene-2-carboxamido)benzoate 
• 1188322-86-2 methyl 3-bromo-5-[2-(thiophen-2-yl)acetamido]benzoate 
• 60912-61-0 methyl 3-bromo-5-acetylaminobenzoate 
• 1188322-78-2 methyl 3-bromo-5-benzamidobenzoate 
• 1188322-88-4 methyl 3-bromo-5-(2-phenoxyacetamido)benzoate 
• 1188322-80-6 methyl 3-bromo-5-(2-methoxybenzamido)benzoate 
• 1188322-76-0 methyl 3-bromo-5-(2-phenylacetamido)benzoate 
• 1188322-82-8 methyl 3-bromo-5-(2,6-dimethoxybenzamido)benzoate 
• 1268704-01-3 methyl 3-(nonylamino)-5-bromobenzoate 
• 1268704-11-5 3-(N-nonyl-N-benzoylamino)-5-bromo-N'-methylbenzanilide 
• 1268704-12-6 3-(N-nonyl-N-benzoylamino)-5-(2'-(5',2''-bithienyl))-N'-methylbenzanilide 
• 1268704-13-7 3-(N-nonyl-N-benzoylamino)-5-(2'-(5',2'',5'',2'''-terthienyl))-N'-methylbenzanilide 
• 1268704-03-5 methyl 3-(nonylamino)-5-(2'-(5',2''-bithienyl))benzoate 
• 1268704-04-6 methyl 3-(nonylamino)-5-(2'-(5',2'',5'',2'''-terthienyl))benzoate 

Relevant articles and documents

Design, synthesis and evaluation of 3-amide-5-aryl benzoic acid derivatives as novel P2Y14R antagonists with potential high efficiency against acute gouty arthritis

P2Y14 nucleotide receptor plays important roles in series of physiological and pathologic events especially associated with immune and inflammation. Based on the 3-amide benzoic acid scaffold reported by our group previously, a series of 5-aryl-3-amide benzoic acid derivatives were designed as novel P2Y14 antagonists with improved pharmacokinetic properties. Among which compound 11m showed most potent P2Y14 antagonizing activity with an IC50 value of 2.18 nM, furnishing greatly improved water solubility and bioavailability compared with PPTN. In MSU-induced acute gouty arthritis model in mice, 11m exerted promising in vivo efficacy in alleviating mice paw swelling and inflammatory infiltration. Mechanistically, compound 11m notably blocked pyroptosis of macrophages through inhibiting NLRP3 inflammasome activation. This work may contribute to the identification of potential therapeutic agents to intervene in acute gouty arthritis.

MACROCYCLIC RIP2-KINASE INHIBITORS

The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of RIP2-kinase, and/or mutants thereof, for use in the diagnosis, prevention and/or treatment of RIP2-kinase associated diseases. Moreover, the present invention provides methods of using said compounds, for instance as a medicine or diagnostic agent.

PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7. (I), wherein R x, R y , R z and R zz are selected from: a) R x and R y are F and R z and R zz are H; b) R x, R y and R zz are independently halogen and R z is H; c) R x R z and R zz are independently halogen and R y is H; and d) R x R y and R z are independently halogen and R zz is H