6092-80-4

Basic information

• Product Name: O-PHENYLHYDROXYLAMINE HYDROCHLORIDE
• Synonyms: O-PHENYLHYDROXYLAMINE HYDROCHLORIDE;PHENOXYAMINE HYDROCHLORIDE;o-PhenylhydroxylamineHCl;HydroxylaMine, O-phenyl-, hydrochloride;O-Phenylhydroxyamine hydrochloride;O-PhenylhydroxylaMine hydrochloride >=97.0% (AT);O-Phenylhydroxylamine hydrochloride Phenoxyamine hydrochloride;O-phenylhydroxylamine
• CAS NO: 6092-80-4
• Molecular Formula: C₆H₇NO*ClH
• Molecular Weight: 145.59
• EINECS: 228-039-0
• Product Categories: Building Blocks;Chemical Synthesis;Hydroxylamines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 6092-80-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: ~132 °C (dec.)
• Boiling Point: 191.9 °C at 760 mmHg
• Flash Point: 82.5 °C
• Appearance: White to yellow/Powder
• Vapor Pressure: 0.504mmHg at 25°C
• Storage Temp.: 2-8°C
• BRN: 4326059
• CAS DataBase Reference: O-PHENYLHYDROXYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: O-PHENYLHYDROXYLAMINE HYDROCHLORIDE(6092-80-4)
• EPA Substance Registry System: O-PHENYLHYDROXYLAMINE HYDROCHLORIDE(6092-80-4)

Safety Data

• Hazard Codes: F,T
• Statements: 11-25
• Safety Statements: 16-22-24/25-45
• RIDADR: UN2811 6.1/PG 3
• WGK Germany: 3
• F: 4.6-10-21
• Hazardous Substances Data: 6092-80-4(Hazardous Substances Data)

Usage

General Description

O-Phenylhydroxylamine Hydrochloride is a synthetic chemical compound that belongs to the class of organic compounds known as phenylhydroxylamines. It is typically used in chemical research and development, specifically in the pharmaceutical sector for the synthesis of novel chemical entities. O-PHENYLHYDROXYLAMINE HYDROCHLORIDE is often obtained as crystalline powder and is moderately soluble in water. Its CAS Registry Number, a unique numerical identifier assigned by the Chemical Abstracts Service, is 1146-14-1. Relevant safety measures should be taken while handling this compound as it may pose harmful effects.

InChI:InChI=1/C6H7NO.ClH/c7-8-6-4-2-1-3-5-6;/h1-5H,7H2;1H

Upstream product

• 100-67-4 potassium phenolate 
• 1236291-45-4 ethyl O-phenylacetohydroxamate 
• 64908-64-1 2-phenoxyisoindol-1,3-dione 
• 98-80-6 phenylboronic acid 
• 4846-21-3 O-phenylhydroxylamine 
• 108-95-2 phenol 
• 76570-49-5 t-butyl N-phenoxycarbamate 

Downstream Products

• 15171-65-0 Phenyl phenoxycarbamate 
• 64584-74-3 (5S,8R,9S,10S,13S,14S,17S)-17-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one O-phenyl-oxime 
• 29127-87-5 benzophenone O-phenyl oxime 
• 29127-93-3 9-fluorenone O-phenyloxime 
• 49540-52-5 1,2,3,4-tetrahydro[1]benzofuro[3,2-c]pyridine hydrochloride 
• 1019995-47-1 C₁₆H₁₄N₂O₂ 
• 1044742-98-4 1-(2-aminophenyl)ethanone O-phenyl oxime 
• 4380-77-2 O-phenylbenzohydroxamic acid 
• 1616624-92-0 6-(2-pyridin-3-ylthiazol-5-yl)pyridine-2-carbaldehyde-O-phenyloxime 

Relevant articles and documents

Synthesis and pharmacological evaluation of benzofuran-acetamides as 'antineophobic' mitochondrial DBI receptor complex ligands

A series of novel benzofuran analogues of N,N-di-n-hexyl-2- phenylindole-3-acetamide (5, FGIN-1-27), a potent and highly specific mitochondrial DBI receptor complex ligand, were synthesized by a modified Fischer method and found in vitro and in vivo to be equally potent and selective as FGIN-1-27.

NOVEL VASCULAR LEAKAGEAGE INHIBITOR

The present disclosure relates to a novel vascular leakage inhibitor. The novel vascular leakage inhibitor of the present invention inhibits the apoptosis of vascular endothelial cells, inhibits the formation of actin stress fibers induced by VEGF, and enhances the cortical actin ring structure, thereby inhibiting vascular leakage. Accordingly, the vascular leakage inhibitor of the present invention can prevent or treat various diseases caused by vascular leakage. Since the vascular leakage inhibitor of the present invention is synthesized from commercially available or easily synthesizable pregnenolones, it has remarkably superior feasibility of commercial synthesis.

Inhibitors of transthyretin amyloid fibril formation

Bisaryloxime ethers and bisarylhydroazones are shown to be effective for inhibiting formation of amyloid fibrils of transthyretin.