609358-56-7Relevant academic research and scientific papers
An electrochemical oxidative multicomponent cascade annulation of ketones and amines used to produce imidazoles
Zeng, Liang,Li, Jing,Gao, Jun,Huang, Xunhai,Wang, Wei,Zheng, Xiaohui,Gu, Lijun,Li, Ganpeng,Zhang, Shengyong,He, Yonghui
, p. 3416 - 3420 (2020)
An electrochemical dehydrogenative [2 + 2 + 1] annulation used for the synthesis of imidazoles has been developed under undivided electrolytic conditions. In an undivided cell, aryl ketones and amines can smoothly participate in this transformation to furnish a variety of substituted imidazoles. The reaction avoids the use of both transition-metal catalysts and peroxide reagents, which makes it more sustainable and renewable.
Practical synthesis of polysubstituted imidazoles via iodine- Catalyzed aerobic oxidative cyclization of aryl ketones and benzylamines
Huang, Huawen,Ji, Xiaochen,Wu, Wanqing,Jiang, Huanfeng
, p. 170 - 180 (2013/03/13)
A practical synthetic method for polysubstituted imidazoles via iodine-catalyzed aerobic oxidative cyclization of aryl ketones and benzylamines has been developed. It was found to tolerate a broad range of substrates to prepare polysubstituted imidazole derivatives in a one-pot manner, and thus importantly allowed product diversity for imidazole chemistry. Additionally, the resultant 1,2,4-trisubstituted imidazoles could be conveniently transformed to functionalized 1,2,4,5-tetrasubstituted imidazoles via electrophilic substitution or direct C-H functionalization, or 2,4-diaryl-1H-imidazoles by debenzylation reaction, which further indicates potential applications of this method in synthetic and pharmaceutical chemistry. Copyright
