60975-82-8

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-PYRIDIN-2-YL-HEPTAN-1-ONE is used as a chemical intermediate for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows it to be a key component in the development of new drugs and agricultural products.
Used in Food Industry:
In the food industry, 1-PYRIDIN-2-YL-HEPTAN-1-ONE is employed as a flavoring agent. Its distinct odor and properties contribute to the creation of specific tastes and scents in food products.
Safety Precautions:

InChI:InChI=1/C12H17NO/c1-2-3-4-5-9-12(14)11-8-6-7-10-13-11/h6-8,10H,2-5,9H2,1H3

Upstream product

• 110-86-1 pyridine 
• 592-41-6 1-hexene 
• 201230-82-2 carbon monoxide 
• 100-70-9 2-Cyanopyridine 
• 3761-92-0 n-hexylmagnesium bromide 
• 109-09-1 2-chloropyridine 
• 70974-42-4 1-(pyrrolidin-1-yl)heptan-1-one 
• 694-59-7 pyridine N-oxide 
• 629-05-0 n-octyne 
• 98-98-6 2-Picolinic acid 

Downstream Products

• 6294-66-2 5-hexyl-5-[2]pyridyl-imidazolidine-2,4-dione 

Relevant academic research and scientific papers

A preparation method of the organic compound (by machine translation)

The invention relates to a preparation method of the organic compound: comprising the following steps: step one: in the nitrogen atmosphere, are added to the organic solvent in the organic carboxylic acid compound with the [...] compound; step two: to a mixture obtained in the step of adding alkyl lithium reagent, after reaction, is restored to the room temperature; step three: step b by heating the reaction mixture; step four: to step three by the electrophilic reagent is added in the mixture, to continue to reaction to obtain the ketone compound; wherein the organic carboxylic acid compound, alkyl lithium reagent, [...] compound and electrophilic reagents of the amount-of-substance ratio of 1.0: 2.5: 1.5: (1.0 - 2.0). The invention in a simple, economic, easy to obtain the raw material of the substrate, with only the addition of alkyl lithium as the activating agent, does not need any catalyst, a step to construct the previous method is difficult to efficient implementation of the ketone compound compound, such compound in the medical synthetic intermediates and organic photoelectric material science in very great application prospect. (by machine translation)

Synthesis, characterisation and reactivity of rare 46-electron tri-ruthenium clusters

[Ru3(CO)12] reacts at room temperature with N-alkyl substituted 6-membered ring N-heterocyclic carbenes (6-NHC) to form [Ru3(6-NHC)(CO)10] (6-NHC = 6-iPr 1, 6-Et 2 and 6-Me 4), rare examples of coordinatively unsaturated (46-electron) ruthenium clusters. Complexes 1, 2 and 4 have been structurally characterised, along with the tetranuclear ruthenium cluster [Ru4(6-Et)2(CO)11] 3 that is formed along with 2. The degradation of the 6-iPr derivative 1 by pyrimidinium salt elimination helped to explain the poor activity of the complex in the catalytic acylation of pyridine.

Room Temperature Metal-Catalyzed Oxidative Acylation of Electron-Deficient Heteroarenes with Alkynes, Its Mechanism, and Application Studies

Herein, we report an original one-step, simple, room-temperature, regioselective Minisci reaction for the acylation of electron-deficient heteroarenes with alkynes. The method has broad functional group compatibility and gives exclusively monoacylated products in good to excellent yields. The mechanistic pathway was analyzed based on a series of experiments confirming the involvement of a radical pathway. The 18O-labeling experiment suggested that water is a source of oxygen in the acylated product, and head space GC-MS experiment shows the C-C cleavage occurs via release as CO2.

Dual Functionalization of α-Monoboryl Carbanions through Deoxygenative Enolization with Carboxylic Acids

A dual functionalization of 1,1-diborylalkanes through deoxygenative enolization with carboxylic acids was developed. 1,1-Diborylalkanes were activated by MeLi to generate α-monoboryl carbanions. In situ IR spectroscopy indicated an interaction between carboxylic acid and 1,1-diborylalkane before addition of the activation reagent. Release of the active α-monoboryl carbanion from the masked form was necessary for its reaction with carboxylate to afford enolate species. Electrophilic trapping of enolate species with various electrophiles achieved dual functionalization of 1,1-diborylalkanes to afford a variety of α-mono, di-, and tri-substituted ketones.

SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION

Pharmaceutical compositions of the invention are presented which comprise substiuted aminothiazoles derivatives. The substiuted aminothiazoles derivatives have a disease-modifying action in the treatment of diseases associated with unregulated cell growth. Such diseases include cancers such as hepatocellular carcinoma, and viral infections from a hepatitis virus.

Naphthalene-catalysed lithiation of chlorinated nitrogenated aromatic heterocycles and reaction with electrophiles

Naphthalene catalysed reductive lithiation of various chloroazines (1, 7, 10, 13) in the presence of different electrophiles yields, after hydrolysis, the expected functionalised heterocycles with one (2, 8), two (11, 14a-d) and three nitrogen atoms in the ring (14e,f). This methodology allowed us to trap in situ the lithium imine derived from the reaction of 2- pyridyllithium with benzonitrile, by reaction with a Grignard reagent in the presence of titanium alkoxides. 2,4-Dimethoxypyrimidines (14a,c,d) are demethylated under acidic conditions to give the corresponding uracil derivatives 16. (C) 2000 Elsevier Science Ltd.

Mammalian exocrine secretions. XII: Constituents of interdigital secretions of bontebok, Damaliscus dorcas dorcas, and blesbok, D. d. phillipsi

In addition to the nine compounds identified in the interdigital secretion of the bontebok, Damaliscus dorcas dorcas, in a previous study, 76 compounds belonging to different compound types, were identified in the interdigital secretions of the bontebok and the blesbok, D. d. phillipsi. These compounds include alkanes, alcohols, aldehydes, ketones, fatty acids, terpenoids, γ-lactones, an isopropyl ester, long-chain hydroxyesters, 2- substituted pyridines, phenols, steroids, and dimethylsulfone. No qualitative differences were found between secretions from the two sexes or from animals from different habitats. Although no attempt was made to correlate territorial behavior or other behavioral phenomena with the qualitative composition of interdigital secretions from individual animals, available information seems to indicate that quantitative differences probably do not have a major semiochemical function. Only two species of bacteria, Bacillus brevis and Planococcus citreus, were found in the interdigital pouches of male and female members of the two subspecies, regardless of the habitat of the animals. B. brevis synthesized, among other unidentified constituents, (Z)-3-penten-2-ol, 2-hexanone, 2-octanone, 2-nonanone, tetradecanoic acid, pentadecanoic acid, heptadecanoic acid, octadecanoic acid, (Z)-9-hexadecenoic acid, and isopropyl hexadecanoate in vitro, while P. citreus produced, among others, the γ-lactones dodecan-4-olide and (Z)-6-dodecen-4-olide, which is one of the major constituents of the interdigital secretions of both subspecies. Some components of the interdigital secretions are not present in the interdigital glandular tissue, and the possibility is discussed that these compounds could be produced by microbiological activity in the interdigital pouch.