60988-43-4Relevant academic research and scientific papers
Novel 2,4-disubstituted-1,3-thiazole derivatives: Synthesis, anti-Candida activity evaluation and interaction with bovine serum albumine
Barta, Gabriel,Foc?an, Monica,G?in?, Luiza-Ioana,Ionu?, Ioana,Marc, Gabriel,Oniga, Ovidiu,P?rn?u, Adrian,Pricopie, Andreea-Iulia,Simon, Elemer,Vlase, Laurian,Vodnar, Dan C.
, (2020)
Herein we report the synthesis of two novel series of 1,3-thiazole derivatives having a lipophilic C4-substituent on account of the increasing need for novel and versatile antifungal drugs for the treatment of resistant Candida sp.-based infections. Follo
Design and synthesis of novel 1,3-thiazole and 2-hydrazinyl-1,3-thiazole derivatives as anti-Candida agents: In vitro antifungal screening, molecular docking study, and spectroscopic investigation of their binding interaction with bovine serum albumin
Pricopie, Andreea-Iulia,Ionut, Ioana,Marc, Gabriel,Arseniu, Anca-Maria,Vlase, Laurian,Grozav, Adriana,Gaina, Luiza Ioana,Vodnar, Dan C.,P?rnau, Adrian,Tiperciuc, Br?ndusa,Oniga, Ovidiu
, (2019/10/02)
In the context of there being a limited number of clinically approved drugs for the treatment of Candida sp.-based infections, along with the rapid development of resistance to the existing antifungals, two novel series of 4-phenyl-1,3-thiazole and 2-hydr
Synthesis and Antitubercular Activity of 4-(5-Nitro-2-furyl/2-pyrazinyl/1-adamantyl)-2-(alkyl/aryl/arylamino)thiazoles
Khadse, B. G.,Lokhande, S. R.,Bhamaria, R. P.,Prabhu, S. R.
, p. 856 - 860 (2007/10/02)
The reaction of haloketones, obtained from Arndt-Eistert reaction on the acid chlorides of 1-adamantane, 5-nitrofuroic acid and pyrazine-2-carboxylic acid, with different thioamides and thioureas affords the title thiazoles (I-III).Some of them exhibit interesting antitubercular activity at 6.25 to 0.38 μg/ml concentration against H37Rv strain of M. tubercolosis in vitro testing.The structure activity relationship (SAR) has also been discussed.
