610300-79-3

Upstream product

• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 38651-65-9 (1R,5S)-(+)-nopinone 
• 145100-51-2 N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 4722-54-7 Isonopinon 
• 610300-90-8 2-[(1S,2R,3S,5R)-3-(diphenylphosphoryl)-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-6-phenylpyridine 
• 610300-78-2 2-[(1S,2R,3S,5R)-3-(diphenylphosphino)-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-6-phenylpyridine 
• 610300-83-9 2-[(1S,2R,3S,5R)-3-(diphenylphosphoryl)-6,6-dimethylbicyclo[3.1.1]hept-2-yl]pyridine 
• 610300-77-1 2-[(1S,2R,3S,5R)-3-(diphenylphosphino)-6,6-dimethylbicyclo[3.1.1]hept-2-yl]pyridine 
• 610300-86-2 2-phenyl-6-[(1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]pyridine 

Relevant academic research and scientific papers

Carbonyl 1,2-transposition through triflate-mediated a-amination

To date, it remains challenging to selectively migrate a carbonyl oxygen within a given molecular scaffold, especially to an adjacent carbon. In this work, we describe a simple one- or two-pot protocol that transposes a ketone to the vicinal carbon. This approach first converts the ketone to the corresponding alkenyl triflate, which can then undergo the palladium- and norbornene-catalyzed regioselective a-amination and ipso-hydrogenation enabled by a bifunctional hydrogen and nitrogen donor. The resulting "transposed enamine" intermediate can subsequently be hydrolyzed to produce the 1,2-carbonyl-migrated product. This method allows rapid access to unusual bioactive analogs through late-stage functionalization.

Catalytic allylic oxidation to generate vinylogous acyl sulfonates from vinyl sulfonates

Regioselective formation of vinylogous acyl sulfonates was accomplished via the allylic oxidation of the corresponding vinyl sulfonates. The reaction progressed through the agency of catalytic iron(III) chloride catalysis with tert-Butyl hydroperoxide (TBHP) as the stoichiometric oxidant. Tolerance of other functional groups, including some other allylic and benzylic sites, was observed.

Chiral ligands and their transition metal complexes

The present invention relates to chiral phosphorus compounds and their transition metal complexes, and also to the use of these transition metal complexes, especially in asymmetric syntheses.

t-BuOK-mediated hydrophosphination of functionalized alkenes: A novel synthesis of chiral P,N- and P,P-ligands

A novel synthesis of effective chiral P,N- and P,P-ligands has been developed by using a t-BuOK-mediated hydrophosphination of chiral alkenylpyridines and alkenylphosphine oxides. Ir complexes of chiral P,N-ligands 1 and 3 gave high enantioselectivities for the hydrogenation of (Z)-α-(acetamido)cinnamate 25 and (E)-1,2-diphenylpropene leading to the hydrogenated products with up to 97% ee.