61068-77-7Relevant articles and documents
Structure-activity relationship study of a series of caspase inhibitors containing γ-amino acid moiety for treatment of cholestatic liver disease
Mou, Jianfeng,Wu, Songliang,Luo, Zhi,Guo, Fengying,He, Haiying,Wang, Jianhua,Lin, Fusen,Guo, Fengxun,Sun, Jianping,Shen, Liang,Zeng, Minggao,Wang, Chuan,Xu, Deming,Gu, Zhengxian,Tian, Xin,Zhang, Aiming,Xu, Hongjiang,Yang, Ling,Zhang, Xiquan,Li, Jian,Chen, Shuhui
supporting information, p. 1874 - 1878 (2018/04/12)
A series of caspase inhibitors containing γ-amino acid moiety have been synthesized. A systemic study on their structure-activity relationship of anti-apoptotic cellular activity is presented. These efforts led to the discovery of compound 20o as a potent caspase inhibitor, which demonstrated preclinical ameliorating total bilirubin efficacy with a significantly improved pharmacokinetic profile.
