116339-27-6Relevant academic research and scientific papers
Detection of ligands from a dynamic combinatorial library by X-ray crystallography
Congreve, Miles S.,Davis, Deborah J.,Devine, Lindsay,Granata, Cesare,O'Reilly, Marc,Wyatt, Paul G.,Jhoti, Harren
, p. 4479 - 4482 (2007/10/03)
A dynamic combinatorial library of ligands derived from hydrazines A and isatins B was assembled in the presence of crystals of the target protein, cyclin-dependent kinase 2 (CDK2). Unambiguous detection of potent ligands, formed as part of the library, was successfully achieved by X-ray crystallographic analysis.
Hydrazone derivatives and their use
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, (2008/06/13)
A method of antagonizing the biological effects of an excitatory amino acid of a subject in need of such antagonization, comprising the step of administering to said subject an effective excitatory amino acid antagonizing amount of an indole-2,3-dione-3-h
