61102-87-2Relevant academic research and scientific papers
Palladium-Catalyzed Direct Decarbonylative Phosphorylation of Benzoic Acids with P(O)–H Compounds
Zhang, Ji-Shu,Chen, Tieqiao,Han, Li-Biao
supporting information, p. 1148 - 1153 (2020/02/27)
A direct decarbonylative phosphorylation of benzoic acids catalyzed by palladium was disclosed. Under the reaction conditions, a wide range of benzoic acids coupled readily with all the three kinds of P(O)–H compounds, i.e. secondary phosphine oxides, H-phosphinates and H-phosphonates, producing the corresponding organophosphorus compounds in good to high yields. This reaction could be conducted at a gram scale and applied in the late-stage phosphorylative modification of carboxylic acids drug molecules. These results well demonstrated the potential synthetic value of this new reaction in organic synthesis.
Practical C–P bond formation via heterogeneous photoredox and nickel synergetic catalysis
Koranteng, Ernest,Liu, Yi-Yin,Liu, Si-Yue,Wu, Qiang-Xian,Lu, Liang-Qiu,Xiao, Wen-Jing
, p. 1841 - 1846 (2019/11/11)
An efficient C–P bond formation reaction was developed by virtue of the synergetic catalysis strategy by merging heterogeneous photocatalysis and nickel catalysis. This platform utilizing cadmium sulfide semiconductors as heterogeneous photocatalysts and
Aromatic phosphorus oxide compounds and preparation method for aromatic phosphorus oxide medicines of same
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Paragraph 0059-0060, (2019/12/25)
The invention discloses a plurality of aromatic phosphorus oxide compounds and a preparation method of aromatic phosphorus oxide medicines of the same. The preparation method comprises the following steps: weighing 1.2 times equivalent of aromatic carboxy
Arenediazonium tetrafluoroborates in palladium-catalyzed C-P bond-forming reactions. Synthesis of arylphosphonates, -phosphine oxides, and -phosphines
Berrino, Roberta,Cacchi, Sandro,Fabrizi, Giancarlo,Goggiamani, Antonella,Stabile, Paolo
supporting information; experimental part, p. 4518 - 4520 (2010/11/17)
A novel palladium-catalyzed synthesis of arylphosphonates from arenediazonium tetrafluoroborates and triethylphosphite or diethylphosphite is presented. The reaction tolerates useful substituents including bromo, chloro, nitro, ether, cyano, keto, and ester groups, can be performed as a one-pot process from anilines omitting the isolation of arenediazonium salts, and can be extended to the preparation of arylphosphine oxides and arylphosphines.
Phosphides and Arsenides as Metal-Halogen Exchange Reagents. Part 2. Reactions with Aromatic Dihalides
Gillespie, Donal G.,Walker, Brian J.,Stevens, David,McAuliffe, Charles A.
, p. 1697 - 1703 (2007/10/02)
1,2-Dihalogenobenzenes react with two molar equivalents of lithium diphenylphosphide in the presence of furan to give, after oxidation, triphenylphosphine oxide (major) and the corresponding 2-halogenophenyldiphenylphosphine oxide.No trace of furan-dehydrobenzene adduct was observed in these reactions; however, 1- and 2-naphthyldiphenylphosphine oxides (9:4) were detected.These compounds were the major products from the reaction of the furan-dehydrobenzene adduct with diphenylphosphide, although the ratio of 1- to 2-isomers was quite different (1:9) in this case.Reaction of lithium diphenylphosphide with 3,4-dichloronitrobenzene gave tetrachloroazobenzene (40percent) as the only isolated product and attempts to replace 1,2-dihalogenobenzenes with 2-halogenobenzenediazonium salts gave much lower yields of products.Although dehydrobenzene is thought to be involved in many of these reactions, alternative mechanisms also operate, depending on the halides used.The reaction of lithium diphenylarsenide with 1,2-dihalogenobenzenes gave triphenylarsine as the major product and it seems likely that similar mechanisms to those involved in reactions of diphenylphosphide are operating.Surprisingly, dehydrobenzene-furan adduct reacted with diphenylarsenide to give naphthalene in high yield.
