61122-85-8

Upstream product

• 504-29-0 2-aminopyridine 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 98-88-4 benzoyl chloride 
• 536-74-3 phenylacetylene 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 21170-60-5 1,3-diphenyl-3-pyridin-2-ylamino-propenone 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 6935-27-9 N-benzylpyridin-2-amine 
• 120422-18-6 (Z)-1,3-diphenyl-3-(pyridin-2-ylamino)prop-2-en-1-one 
• 120-46-7 1,3-diphenylpropanedione 
• 159639-03-9 1,3-diphenyl-3-(pyridin-2-yl)aminopropan-1-one 
• 94-41-7 benzalacetophenone 
• 856815-39-9 2-(2-imino-2H-[1]pyridyl)-1,3-diphenyl-propane-1,3-dione 

Relevant academic research and scientific papers

Copper-catalyzed oxidative multicomponent reaction: Synthesis of imidazo fused heterocycles with molecular oxygen

An oxidative cascade that involves multicomponent reaction comprising a terminal alkyne, 2-amino N-heterocycle, benzyl or allylic bromide with molecular oxygen, delivering densely functionalized imidazo fused heterocycles, is described. This reaction features a cheap catalyst, a green oxidant, and readily available starting materials, which make the overall synthesis applicable in the quick access to relevant pharmaceutical molecules with imidazole derived heterocycles.

A transition metal-free cascade reaction using heterogeneous tin(IV)oxide catalyzed and iodine promoted synthesis of 3-aroylimidazo[1,2-a]pyridines

The cascade synthesis of 3-aroylimidazo[1,2-a]pyridines using chalcones and 2-aminopyridine was achieved over the SnO2/I2 catalytic system in toluene at ambient air atmosphere. The catalyst shows high activity towards the broad subst

Superparamagnetic nanoparticle-catalyzed coupling of 2-amino pyridines/pyrimidines with trans-chalcones

An aerobic coupling of 2-aminopyrimidines or 2-aminopyridines with trans-chalcones to afford aroylimidazo[1,2-a]pyrimidines and aroylimidazo[1,2-a]pyridines is reported. Reactions proceed in the presence of CuFe2O4 superparamagnetic

Copper-Catalyzed C-N Bond Formation via C-H Functionalization: Facile Synthesis of Multisubstituted Imidazo[1,2- a ]pyridines from N -(2-Pyridinyl)enaminones

An efficient, new copper-catalyzed approach to the construction of the multisubstituted imidazo[1,2- a ]pyridine skeleton from N -(2-pyridinyl)enaminones has been developed.

Iodine/Copper Iodide-Mediated C-H Functionalization: Synthesis of Imidazo[1,2-a]pyridines and Indoles from N-Aryl Enamines

A practical intramolecular C-H functionalization reaction of N-aryl enamines has been carried out with molecular iodine (I2) as the sole oxidant in the presence of copper iodide (CuI). The efficient and versatile synthetic method described here

Copper-catalyzed intramolecular oxidative amination of enaminone C-H bond for the synthesis of imidazo[1,2-a]pyridines

The intramolecular C-N bond forming cross coupling reactions on the enaminones has been achieved for the synthesis of imidazole[1,2-a]pyridines via copper-catalyzed C(sp2)-H amination. This protocol provides a new route for the synthesis of 2-u

Copper catalyzed aerobic oxidative cyclization and ketonization: One pot synthesis of benzoimidazo[1,2-: A] imidazolones

A highly efficient synthesis of benzoimidazo[1,2-a]imidazolone through a novel oxidative 5-exo-dig cyclization-ketonization cascade of 2-aminobenzimidazole, aldehyde and terminal alkyne has been explored under aerobic conditions. The reaction proceeds thr

Copper supported on H+-modified manganese oxide octahedral molecular sieves (Cu/H-OMS-2) as a heterogeneous biomimetic catalyst for the synthesis of imidazo[1,2-a]-N-heterocycles

Copper supported on acid-modified manganese oxide octahedral molecular sieves (Cu/H-OMS-2) was prepared and found to be a versatile catalyst for the oxidative synthesis of 3-aroylimidazopyridines with a broad substrate scope. Cu/H-OMS-2 that was character

Iodine-promoted oxidative coupling reaction: a simple and efficient process to access imidazo[1,2-a]pyridines from 2-aminopyridines and chalcones

A unique and efficient approach has been developed for the synthesis of substituted imidazo[1,2-a]pyridines with aminopyridines and chalcones via a one-pot I2-induced aerobic oxidative coupling. The reported reaction proceeded though a tandem Michael addition followed by an intramolecular oxidative amination with high regioselectivity, yields and good functional group tolerance.

Synthetic method of imidazo[1,2-a]pyridine

The invention discloses a novel method for synthesizing imidazo[1,2-a]pyridine. According to the method, imidazo[1,2-a]pyridine is synthesized from 2-aminopyridine and chalcone through oxidization cyclization by taking 1,2-dichloroethane as a solvent and iodine as a catalyst. The method has the advantages that the operation is simple, the raw materials are easily available, reaction conditions are mild, the yield is relatively high, and the practicability is strong. The method is applicable to industrial production.