61123-44-2

Basic information

• Product Name: 1-(morpholin-4-yl)-4-phenylbutan-1-one
• CAS NO: 61123-44-2
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.3062
• Mol File: 61123-44-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 407.7°C at 760 mmHg
• Flash Point: 200.4°C
• Density: 1.092g/cm³
• Vapor Pressure: 7.41E-07mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: 1-(morpholin-4-yl)-4-phenylbutan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(morpholin-4-yl)-4-phenylbutan-1-one(61123-44-2)
• EPA Substance Registry System: 1-(morpholin-4-yl)-4-phenylbutan-1-one(61123-44-2)

Safety Data

• Hazardous Substances Data: 61123-44-2(Hazardous Substances Data)

Usage

General Description

1-(morpholin-4-yl)-4-phenylbutan-1-one is a chemical compound with the molecular formula C14H19NO2. It is a substituted ketone and contains a morpholine ring. 1-(morpholin-4-yl)-4-phenylbutan-1-one is commonly used as an intermediate in the synthesis of pharmaceutical drugs, such as acepromazine, a tranquilizer, and ticlopidine, an antiplatelet drug. It is also used in research laboratories as a reagent in organic synthesis. The compound has various chemical and biological properties, and its structure makes it a versatile building block for the production of a wide range of organic compounds. However, it should be handled with care as it can be toxic if ingested or inhaled and may cause irritation to the skin and eyes.

Upstream product

• 1462-75-5 3-phenylpropylmagnesium bromide 
• 110-91-8 morpholine 
• 1821-12-1 4-Phenylbutyric acid 
• 38282-01-8 N-[(E)-3-phenyl-2-propenyl]diethylamine 
• 2051-95-8 succinylbenzene 
• 101012-63-9 2-bromo-4-phenyl-4-butanolide 
• 15159-40-7 4-morpholinocarbonyl chloride 
• 6045-93-8 1-morpholino-4-phenylbutane-1,4-dione 
• 18496-54-3 phenylbutyric acid chloride 

Downstream Products

• 18328-11-5 3-benzyl propionaldehyde 

Relevant articles and documents

Direct amide formation in a continuous-flow system mediated by carbon disulfide

Amide bonds are ubiquitous in nature. They can be found in proteins, peptides, alkaloids, etc. and they are used in various synthetic drugs too. Amide bonds are mainly made by the use of (i) hazardous carboxylic acid derivatives or (ii) expensive coupling agents. Both ways make the synthetic technology less atom economic. We report a direct flow-based synthesis of amides. The developed approach is prominently simple and various aliphatic and aromatic amides were synthetized with excellent yields. The reaction in itself is carried out in acetonitrile, which is considered as a less problematic dipolar aprotic solvent. The used coupling agent, carbon disulfide, is widely available and has a low price. The utilized heterogeneous Lewis acid, alumina, is a sustainable material and it can be utilized multiple times. The technology is considerably robust and shows excellent reusability and easy scale-up is carried out without the need of any intensive purification protocols.

Rhodium-Catalyzed Asymmetric Synthesis of β-Branched Amides

A general asymmetric route for the one-step synthesis of chiral β-branched amides is reported through the highly enantioselective isomerization of allylamines, followed by enamine exchange, and subsequent oxidation. The enamine exchange allows for a rapid and modular synthesis of various amides, including challenging β-diaryl and β-cyclic.

Dosing form for reagents, use of said dosing form in organic chemical synthesis and production of said dosing form

A dosing form for at least one solid reagent for use in conventional organic and inorganic synthesis, in parallel synthesis, and in split and mix synthesis in combinatorial chemistry is provided as compressed tablets each containing the same predetermined amount of said at least one reagent embedded in a polymer matrix comprising beads of a polymer insoluble in the solvents for the intended synthesis, which tablets are capable of disintegrating in said solvent for release of the at least one reagent and disperse the matrix as polymer beads into the solvent. The polymer beads forming the matrix and the reagents of the dosing form can easily be removed by filtration in order to separate these from a formed soluble product. In a method for producing the dosing form, beads of one or more polymers are mixed with the reagents and compressed into tablets after pre-treatment with an aprotic organic solvent.